DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and lrig2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_021332954.1	Gene:	lrig2 / 571101	ZFINID:	ZDB-GENE-041111-75	Length:	1044	Species:	Danio rerio

Alignment Length:	494	Identity:	119/494 - (24%)
Similarity:	194/494 - (39%)	Gaps:	103/494 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RGEEILLPDLSDVAGRYVVLAASGDLY-----VRSV--RSEDGLMKFSCLVTNTLNGERQRSDAV 233
            |..||.|. :.|..|.:|.|.....|.     :|::  |:.:|||:
Zfish   325 RNNEISLA-IEDFIGMFVGLKRLNSLVLQNNKIRTITKRAFEGLME------------------- 369

  Fly   234 MLQVKELSKNLAPRTTQKPVMEIHVERG----------NDVHLPCNIQGNPFPIFTWY------- 281
             |:..:||||        .:|.||.:..          |...|.|:.|      ..|.
Zfish   370 -LENLDLSKN--------GIMSIHPDAFTHLKLKTLDLNSSSLLCDCQ------LQWLGQWLINS 419

  Fly   282 RVSDS-AALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHI 345
            |...| .|:...|:|   :...::|.:|..:      ::|   :.|.:.:|          :.|
Zfish   420 RFQQSCTAVCAHPAS---LAGSSVLAVKPEE------FVC---SDFPKPQI----------TAH- 461

  Fly   346 LPQVQIVNSGGTANFNCTTTGSAIDAID--WLHNGKPLQANNALTTGR-DNIRFLSKSSLLVQNV 407
             |:..:...|.....||:...|:...:.  |..:|:.|.........| .:.|.|..:.|.:.||
Zfish   462 -PKTAVALRGTNVTLNCSAFSSSDSPMSTAWRKDGEVLYEAQVQNYARYQDQRLLYTTILHLLNV 525

  Fly   408 GRRDRGVYQCLVENQRAS-AQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFA 471
            ...|.|.|||::.|...| ...:|:|.:.: :|..:.|.::..:|.|.:..|:|:|.|.|.||.|
Zfish   526 NFTDEGQYQCVLSNHFGSNYSTLAKLTVNE-LPTFLKTPMDLTIRTGTVARLECAAEGHPTPQIA 589

  Fly   472 WLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNV 536
            |..|.......:...|..:     |..|  ....|::|:.:|.|:|.|.|.|..||:..:|.|.|
Zfish   590 WQKDGGINFPAARERRMHV-----MPDD--DTFFIANVKAEDMGVYSCTAKNEAGSLSANATLTV 647

  Fly   537 Y-GPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELT-TSNHYELASVADGGQLVIK 599
            . .|.:.|.:.......||..::.|...|.|..::.|.|....|. |..|:..|:   ...|:|.
Zfish   648 LETPSFQRPLEDRNVARGETAVLQCIARGSPAPRLNWTKDDAPLVLTERHFFAAA---NQLLIIV 709

  Fly   600 NVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEP 638
            :..|. |.|.||||:.:..|.| |..:.|:|:.....:|
Zfish   710 DAGPA-DAGKYTCIMSNTLGTE-RGHIYLSVSPSANCDP 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	18/108 (17%)
		Ig	264..334	CDD:143165	14/77 (18%)
		I-set	345..433	CDD:254352	22/91 (24%)
		Ig	358..431	CDD:143165	19/76 (25%)
		Ig	456..533	CDD:143165	23/76 (30%)
		IGc2	553..619	CDD:197706	20/66 (30%)
		I-set	634..724	CDD:254352	1/5 (20%)
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
lrig2	XP_021332954.1	NEL	<7..>191	CDD:330839
		leucine-rich repeat	38..57	CDD:275380
		leucine-rich repeat	58..81	CDD:275380
		leucine-rich repeat	83..104	CDD:275380
		PLN00113	<128..>403	CDD:331614	23/106 (22%)
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..174	CDD:275380
		leucine-rich repeat	175..198	CDD:275380
		leucine-rich repeat	199..246	CDD:275380
		leucine-rich repeat	247..270	CDD:275380
		LRR_8	270..329	CDD:316378	1/3 (33%)
		leucine-rich repeat	271..294	CDD:275380
		leucine-rich repeat	295..318	CDD:275380
		leucine-rich repeat	319..345	CDD:275380	8/20 (40%)
		leucine-rich repeat	346..369	CDD:275380	5/22 (23%)
		leucine-rich repeat	370..391	CDD:275380	8/28 (29%)
		LRRCT	403..451	CDD:214507	12/65 (18%)
		Ig	459..553	CDD:325142	24/95 (25%)
		Ig_1	574..648	CDD:143240	25/80 (31%)
		I-set	651..738	CDD:254352	26/91 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910