DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and ush2a

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_009291422.1 Gene:ush2a / 568982 ZFINID:ZDB-GENE-060503-794 Length:5243 Species:Danio rerio


Alignment Length:2536 Identity:493/2536 - (19%)
Similarity:766/2536 - (30%) Gaps:981/2536 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EPPCLVLEKALLLGALLLAVLATPL---LATSGLRVPTFL----LEPAPRLLFGNDTGAQVTCTA 62
            |||  ||...:::...|...|...|   .::.|.....||    |.|.|.|...|:         
Zfish  1279 EPP--VLPNGIIIRYELFMQLLNELQRNASSYGTEQRVFLSSGWLNPRPSLSSANE--------- 1332

  Fly    63 HGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCR--ASNEAGTV 125
            :...||..|.|:.                    :..||           :|||.|  ..|.||:|
Zfish  1333 NALTPPESTVVVS--------------------NLQPF-----------STYRFRVLTVNMAGSV 1366

  Fly   126 LSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRP---------YVRVASWHRGEEIL 181
            ||                    :..:|.:|.   .:|||:.|         .:|| ||.      
Zfish  1367 LS--------------------DWAVGRTAE---GVPEYMAPPQVSAVSSSSLRV-SWE------ 1401

  Fly   182 LPDLSDVAGR----------------YVVLAASGDLYVRSVRSED----GLMKF----------- 215
            .|...||.|.                |.....:..||..|.:...    ||..:           
Zfish  1402 TPRDKDVRGEVTEYRVNLHQEQMSNPYAPPIVTQVLYSGSAQEHSYTAGGLKAYEEYSFTVTVCN 1466

  Fly   216 --SCLVTNTLNGERQRSDAVMLQVKEL------SKNL---APRTTQKPVMEIHVERGNDVHLPCN 269
              .|:.::..:|....|....|:...|      :.|:   ||.....|....|||| .||.| .:
Zfish  1467 RQGCVSSSPASGRTLPSAPAGLRAPGLRPLNMTAMNVFWDAPAELNGPPPLYHVER-TDVSL-SD 1529

  Fly   270 IQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNAD----------ERDAGKWICQASN 324
            .||.   :....|.:.| ..:..||:         .|..|||          ..:.|..:...|.
Zfish  1530 AQGQ---VIRGRRFTGS-GFFRFPSA---------TLPVNADFTGLQLSFRTRAEEGLLLFAVSP 1581

  Fly   325 QFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPL-----QAN 384
              |||        ..||::.|                              |||:|.     ||:
Zfish  1582 --GEQ--------EEYVALQI------------------------------HNGRPYFLFDPQAS 1606

  Fly   385 NALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQ-RASAQAMAELKLGDT----------- 437
            ....:.|::.......:.....:..|.:.|...:|:|| ..||.|.:    |.|           
Zfish  1607 AVALSPRNDGGRRYNDNQWHHLIATRKQAVGTIIVDNQYSGSASATS----GSTIIGQNTGVFIG 1667

  Fly   438 -VPELIYTFIEQNVRPGPLIS----------LKCSASGSPPPQFAW-LLDSQPIMD--------- 481
             :|| .:|.:.|:.....|:.          |...:||:   ..|| .||.:..::         
Zfish  1668 GIPE-NFTILRQDAGQAKLVQQGFAGCLRDVLVQKSSGA---NEAWEPLDWESALETHETYESWE 1728

  Fly   482 ----VSLHHRFAIGQ-FVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPY 541
                ||.:..:.:|. |:.:..::::           ||.|..::........::..|..|.   
Zfish  1729 GCPAVSENGAYFLGHGFLKVKPEILT-----------GGNYFEISFEFKTDQLNALLLFAYD--- 1779

  Fly   542 VRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTT------------------------- 581
                     :.|:|.|:.....|.....:||.:...||:.                         
Zfish  1780 ---------IDGKDFILAELQGGVLFWVLRWGEQTVELSVWVGLSYCDGGWNTLSVLKRGHLASA 1835

  Fly   582 --SNHYELASVADGGQLVIKN------VEPGRD----------QGIYTCIVRSRAGEEARRDMQL 628
              ::.||....|.||.|.|.:      |.||..          .|...||          ||::|
Zfish  1836 GLNDMYEQERKAIGGPLTISSPLYIGGVPPGVTHPALNKHSLLHGFGGCI----------RDVRL 1890

  Fly   629 ---------NVNSPPV------------------------------------IEPF-KFPKNLQ- 646
                     .|:|..|                                    ::|| ::...:. 
Zfish  1891 ARGPVVSLAAVSSSAVRVNLDGCLSADTSVNCRGNDSILVYTGRDRSAEDLTLQPFTEYLYRVMA 1955

  Fly   647 --EGG-------RAQITCAVSSGDMP-----------IYFSWKKDDSSIPSSLQ-ITEKKEEFYS 690
              |||       |.:....|....:|           :..||::     |:.:: :.||    |.
Zfish  1956 SGEGGWIGGPWQRGRSRETVPQSVLPPSRVGSVNGSSVEVSWEE-----PAEVRGVIEK----YV 2011

  Fly   691 LLVF-------KDISAR--HSGKYT-----------------------CYASNAAAKVNYTAELQ 723
            |..:       ..|||.  ||...|                       |..|..|...|...|..
Zfish  2012 LKAYSRDRPSSSPISATFPHSQHLTGTLSGLAPFSSYSITLTACTQAGCSESPFATGFNTPQEAP 2076

  Fly   724 VRVAP------------RWRYEPMDTAIML-------------GNTISINCEAEGYPIPTITWFK 763
            ..|.|            .|.:.|....|::             ||:.|.|....|.         
Zfish  2077 EEVPPPAAVSYPNSLSVHWNHPPKPNGIIIQYILYKNNTVLYRGNSTSFNITDVGV--------- 2132

  Fly   764 GQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRIN----------VNEP 818
                    |.|     |.|||:..|:               ||...:.::.          |..|
Zfish  2133 --------FTP-----HKLLLSACTE---------------AGCTNSTQVTLFTGQLPPTYVEPP 2169

  Fly   819 ARFEQSARNISSRRNDPV---------TLDCHAKGDEPITI--------GWTQNNGRIDLNNFRF 866
            ......||:|..:...||         ||...|.|:||:.:        .:|..| .:..:.:.|
Zfish  2170 ILTVLDARSIHIQWAAPVEVNGLLEFYTLHQWALGEEPLIVYNSSELFQDYTVRN-LVPGSTYLF 2233

  Fly   867 SIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSR 931
            .||          ..|.|.....|....|....:|             |....|:   |..:...
Zfish  2234 QIA----------ACTGGGCTLSDPSTARTEESSP-------------EEVPAPN---ILSLSPH 2272

  Fly   932 TVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDW-NGHVI-NVSLPSTSISRSYDSD 994
            ::.|||..|...|..:.||                    |.| :|.:: |.||.::.        
Zfish  2273 SLHLSWTPPRKPNGVISSY--------------------GLWMDGTLVQNSSLMASE-------- 2309

  Fly   995 LRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAP---------TEAPSNVQVQTG 1050
                  |..|:|.:....|:||.. .:..|....:..:|.|..|         :|.|.:|:.:  
Zfish  2310 ------VGDLSPWSLHSFRVQACT-AQGCALGPLVESRTLEMPPVGHVTLVVFSETPHSVRAK-- 2365

  Fly  1051 GESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRK 1115
                    |:.|...  ||.|. |||..:...||.:.:...::.::..:.:|......::.||..
Zfish  2366 --------WEAPAEP--NGNLT-YTVLFAGPGQNFSSLDTPDTEMRELLSTGKEGQWVSIGGLLP 2419

  Fly  1116 YSRYAVTIRAMNSFG---SGPWSAAIFGTTAEGVPEAAPQNV---NCTALSSQSLKISWLEPPLQ 1174
            ||.|:|.::|.||.|   |.|.|.::        |..||..:   ...|.:..||::||..|...
Zfish  2420 YSNYSVMVKACNSLGCVESSPVSVSL--------PPGAPDGLLAPRLAAATPTSLQVSWAAPARH 2476

  Fly  1175 FHGGIIQGYKILYRPI----VHQIDFPAKLEIKRTSNLETYLHT---LHKASNYSIRVLAYTATG 1232
            ...|.:: |::..|..    :||:     ::.:.|    |:.||   |...:.|..|:|...:.|
Zfish  2477 NAPGALR-YRLQMRSSASTQLHQL-----MDDETT----TFSHTVTDLEPFTEYHFRLLVSNSYG 2531

  Fly  1233 DGLASHP---LFCQTDDDVPDAPAAIKAAALT---ADSILISWLTPKNRNGIISHYTVYSREAGR 1291
            :  .|.|   ||     ...|.|.|:....|:   :.|..|||..|...||||:||.:|      
Zfish  2532 E--TSSPWVSLF-----TAQDRPGAVDPPVLSDIQSRSAFISWSPPSQPNGIITHYNIY------ 2583

  Fly  1292 KGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVG----------------------- 1333
              |.:.....|.||.  .:.....|...|.|...|.|.|:.|                       
Zfish  2584 --QNRQLTTSVPENS--TSHMLSHLTPFQQYTIQVEACTAAGCTLSAESHTINTPPAPPEDVPAP 2644

  Fly  1334 ---EGEPTSVIAQATNTRAPARIAS--FGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTF 1393
               ...||||:   .:..||..:..  .|..|.:.|.....:..:|...|.....:|  |...|.
Zfish  2645 QLYSDTPTSVL---LSWAAPRLVNGELDGYTVERRVSGTQEISTVATIQPNQTLTYL--DSSATL 2704

  Fly  1394 SPF--YEVTNEGNLKIHRVEGSLSGNYTCTAN-NLFGSDEIQYQVIAMKP--PSA---PQIIVQY 1450
            ||:  ||                   |...|: .|.||:...::.:..:|  |:.   |..:|  
Zfish  2705 SPWSSYE-------------------YRIVAHTRLGGSNSSVWEKVTTRPSRPAGMQPPDGVV-- 2748

  Fly  1451 ASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWSITELLPENN----AFTISGLKCGNQYIIKM 1511
            ...:|::|:|.||......::.|.|...        ...:|..|    ..|:|||.....|.|.:
Zfish  2749 LGPESVQVTWAAPLIPNGEIERYEIRMP--------EPRIPHTNMSLLTHTVSGLMPYTGYSITI 2805

  Fly  1512 SA------HNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIHHFSI 1570
            .|      |  ||....|....|.|.....|..:...::|.:.:.:.:   |||          :
Zfish  2806 LACSGGGGH--VGGCTESLPTLVTTLPTIPQGLSPLSVVAISESFLAV---SWQ----------L 2855

  Fly  1571 EHRPLG-DIRWTVVTSDISNAEENRE----NLIFCDFLPAK------------WYQLRISATNDA 1618
            ..||.| :||:.::.........:|.    ||.:..:...|            ||:.:|...||.
Zfish  2856 PSRPNGPNIRFELLRRKTQQPLASRPPEDFNLWYNVYAGTKLFHEDKGLSRYTWYEYKIVVHNDV 2920

  Fly  1619 GKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIAL 1683
            |..:.......| :.|..:.|.::.....:....|:|.|.||..|...::.|.::..||      
Zfish  2921 GSASGEVATGVT-LAGQPLKPTNISAHALNHTAILVNWTTPTLQDLQGSVEVYILTVVS------ 2978

  Fly  1684 TIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQVYSASPVKT---VDKGNESEMYEISPYAT 1745
             .:|.:||                              :..|..|   :.....|..|::|    
Zfish  2979 -DQHSQTL------------------------------TLDPTVTSVFIPDLQPSTQYKLS---- 3008

  Fly  1746 FSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEGE------NLNATAY------PLLPSS 1798
            .:|:.|    |....:..|...|         |.|.|||.      .||:||.      ||||: 
Zfish  3009 LTVSNG----PHNITSPEVNCTT---------TDGEPEGVFPPEVLTLNSTAVRVMWAPPLLPN- 3059

  Fly  1799 GFGHVKSKSSWHKQRYYNTEDESTLSKSMTIVAGS---QAGHS-----------KKSN------- 1842
              |.|...|.:...|.|.    ||.::|.::..|.   ...||           .|||       
Zfish  3060 --GVVVQYSIYLDGRLYG----STGNESGSLEMGGLLPYTVHSIQVEVCTVYACVKSNSTQVTTV 3118

  Fly  1843 ---------------GGRSAK----SSAACSGVVAG-------------SESDTSISPSTEFSNM 1875
                           ..||.|    |....:|::.|             .::..:.:|.:..|.:
Zfish  3119 EDTPAEISTPHIQVLSSRSVKLEWTSPGRPNGILGGYDVWRRTLKRCEDLQTQQTFAPQSRCSYL 3183

  Fly  1876 PTYRVPCKSSRSSDGRAVVDMFRPD-----SSTESNNDQGSPAPERRHNTPRHVLGMGMAMGLGG 1935
                 .|.:.:...|:.   .:.|:     |.|..|..|.....|.|:.                
Zfish  3184 -----ECPAEQDFCGKT---CYNPEMQICCSGTVHNLIQSHQCCEERYI---------------- 3224

  Fly  1936 GGGGGVGGGNGPAEKRSAGQRSRKHGSAAQQPSNQTLERRKC---------PGSSNSLDSEVDAE 1991
                       ||.:.|.   |...|....||    |.:.:|         ||....|||   .|
Zfish  3225 -----------PASEDSG---SVCCGGQFVQP----LSQHQCCGGYHVLVSPGEVCCLDS---VE 3268

  Fly  1992 TAASLAASIAAMAG----SGAGADLSGGFRPPAGFHDGRE---------PGDHSDCEREQRALDL 2043
            ...|:....:..||    ||.|....||     ..:||.:         |.:...|..|:..:..
Zfish  3269 QRVSVGLGDSCCAGRPFVSGVGQICCGG-----RLYDGFKSQCCGGQLVPRETECCGDEEEGISY 3328

  Fly  2044 E 2044
            |
Zfish  3329 E 3329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 16/78 (21%)
Ig 56..125 CDD:143165 13/70 (19%)
I-set 246..337 CDD:254352 24/100 (24%)
Ig 264..334 CDD:143165 17/79 (22%)
I-set 345..433 CDD:254352 16/93 (17%)
Ig 358..431 CDD:143165 15/78 (19%)
Ig 456..533 CDD:143165 14/101 (14%)
IGc2 553..619 CDD:197706 21/108 (19%)
I-set 634..724 CDD:254352 27/180 (15%)
ig 645..712 CDD:278476 21/120 (18%)
IG_like 734..815 CDD:214653 16/103 (16%)
Ig 745..815 CDD:299845 12/79 (15%)
I-set 820..913 CDD:254352 21/109 (19%)
Ig 838..920 CDD:299845 16/89 (18%)
FN3 917..1033 CDD:238020 22/117 (19%)
FN3 1040..1142 CDD:238020 27/104 (26%)
fn3 1150..1237 CDD:278470 22/96 (23%)
FN3 1263..1345 CDD:238020 27/107 (25%)
Ig 1350..1436 CDD:299845 18/90 (20%)
IG_like 1358..1436 CDD:214653 16/80 (20%)
FN3 1441..1530 CDD:238020 24/101 (24%)
FN3 1542..1620 CDD:238020 18/94 (19%)
ush2aXP_009291422.1 Laminin_G_3 160..297 CDD:290121
Laminin_N 307..528 CDD:295486
EGF_Lam 529..577 CDD:238012
EGF_Lam 586..638 CDD:238012
Laminin_EGF 653..703 CDD:278482
Laminin_EGF 706..756 CDD:278482
EGF_Lam 759..797 CDD:214543
Laminin_EGF 808..857 CDD:278482
EGF_Lam 859..912 CDD:238012
EGF_Lam 913..963 CDD:238012
EGF_Lam 965..1014 CDD:238012
EGF_Lam 1015..1064 CDD:238012
FN3 1177..1253 CDD:238020
FN3 1264..1375 CDD:238020 33/157 (21%)
FN3 1386..1469 CDD:214495 14/89 (16%)
LamG 1537..1699 CDD:238058 38/216 (18%)
LamG 1737..1890 CDD:238058 30/185 (16%)
FN3 1981..2071 CDD:238020 17/98 (17%)
FN3 2163..2253 CDD:238020 21/100 (21%)
FN3 2258..2341 CDD:238020 24/133 (18%)
FN3 2352..2443 CDD:238020 26/103 (25%)
FN3 2447..2544 CDD:238020 26/113 (23%)
FN3 2547..2633 CDD:238020 26/95 (27%)
FN3 2635..2733 CDD:238020 23/121 (19%)
FN3 2743..2807 CDD:238020 17/73 (23%)
FN3 2830..2932 CDD:238020 20/114 (18%)
fn3 2939..3014 CDD:278470 19/115 (17%)
FN3 3032..>3099 CDD:238020 22/73 (30%)
FN3 3542..3611 CDD:238020
FN3 3615..3701 CDD:238020
fn3 3718..3784 CDD:278470
FN3 3801..3887 CDD:238020
FN3 3908..3971 CDD:238020
FN3 3996..4086 CDD:238020
FN3 4186..4284 CDD:238020
fn3 4288..4366 CDD:278470
FN3 4382..4465 CDD:238020
FN3 4470..4553 CDD:238020
FN3 4555..4653 CDD:238020
FN3 4679..4753 CDD:238020
fn3 4760..4830 CDD:278470
FN3 4864..4955 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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