DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and aebp1b

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	781	Identity:	146/781 - (18%)
Similarity:	234/781 - (29%)	Gaps:	272/781 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGR 904
            |....|.. .|.|...||...|.  :....::.....|.|.||:.:::.:::|:|:|:|.|....
Zfish    77 CKVSSDAK-NINWVSPNGEKVLT--KHGNLKVHNHGSVLSSLTVLNANLNNAGIYKCVATNGDTE 138

  Fly   905 AEQIIFLAV---QERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSL 966
            ::..:.|.:   :.|.||       :...|..:|  :.|.....|        :|.|..:...|.
Zfish   139 SQATVKLDIILKRMRRDT-------DRKGREKRL--KEPKPSKKP--------KASKPTKKPKSE 186

  Fly   967 AAAGGDWNGH-------------VINVSLPSTSISRSY------------DSDL-RESAIVAGLT 1005
            ....|:..|.             ......|:|::...|            |.|. .|:..||..|
Zfish   187 KKGKGEKGGKKKGKKNREESTTVATTTVAPTTTVPMEYEEFYDPEPDQYWDEDFPAETTTVARTT 251

  Fly  1006 PATT-----FLIRMQAINEIERSAYTEAIVLKTQEEAPT--------------------EAPSNV 1045
            ...|     |:..|...::.:  :|.:  ..|..|..||                    |...|:
Zfish   252 TTPTEKTKDFIPDMDEYSQPD--SYDD--YWKVDEPTPTTSVIAGRPADDDDYWDARSVEMVENL 312

  Fly  1046 QVQTGGE-SELIVTWQ--------IPPRE-SWNGEL-IGYTVNCSEEKQNI-------------- 1085
            ....|.| |.....||        :||.| ||..|. .|:.....||::.:
Zfish   313 PFPDGKEISSTDNDWQYTTTEEPTVPPFENSWYEEYEYGHEKKLEEERERLRKEQEEKEREERKR 377

  Fly  1086 -----------------------------NFISVVNSSLKSTIVSGWATTKATLRGLRKYS--RY 1119
                                         ....:.|..|.::.|.           ..:|.  |.
Zfish   378 LEEEERERRIYRPPPRVYREPKICPPLGMESHRIDNDQLLTSSVF-----------QHRYGSHRA 431

  Fly  1120 AVTIRAM---NSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPP----LQFHG 1177
            .:.|:|.   :....|.|.|.         ||.               |:.|:|..    .:|.|
Zfish   432 RLNIQASGDDDDMNGGAWCAN---------PEE---------------KVHWIEVDARTLTEFTG 472

  Fly  1178 GIIQGYKILYRPIVHQIDFPAKLEIKRTSNLET-YLHTLHKASNYSIRVLAYTATGDGLASHPLF 1241
            .|.||                     |...||: |:.|.:.|.:...|  .:|...||.|....|
Zfish   473 VITQG---------------------RDDPLESDYVSTYYVAFSNDSR--EWTFLHDGYAEWLFF 514

  Fly  1242 CQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGI---------------ISHYTVYSREAGR 1291
            ..:|.:.|.....::........||     |::.||.               :|.:...:....|
Zfish   515 GNSDKNTPVLSQFMEPVVARYIRIL-----PQSWNGTMCMRMEILGCPVQDPLSQHQSENEVTRR 574

  Fly  1292 KGQAKTH---------MVRVDENGYPVT-FES--RSLAENQMYEFWVSASTSVGE-GEPTSVIAQ 1343
            .....||         |..:.:....:| |.|  :|....::|...::.:..|.| |||
Zfish   575 DNLDYTHHNYLDMEKLMKSISDECPNITRFYSLGKSFKGLEIYAMEITDNPGVHETGEP------ 633

  Fly  1344 ATNTRAPARIASFGQVVRKAVGTGLVLE-----CLAVGNPTPRARWLTRDRPVTFSPFYEVTNEG 1403
              ..|..|     |....:|:|..|:|.     |....:..||.|.|..:..:...|  .|..:|
Zfish   634 --EFRYTA-----GYHGNEALGRELLLMFMQYLCKEYKDGNPRVRHLVDETRIHLVP--SVNPDG 689

  Fly  1404 NLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGA 1468
            ::|... :||..|::|.......|.|..|         :.|         |...:.||:.|.|..
Zfish   690 HVKAFE-KGSELGSWTLGHWTEDGHDIFQ---------NFP---------DLNNIYWDSEDKGMV 735

  Fly  1469 P 1469
            |
Zfish   736 P 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352	17/72 (24%)
		Ig	838..920	CDD:299845	19/82 (23%)
		FN3	917..1033	CDD:238020	24/146 (16%)
		FN3	1040..1142	CDD:238020	26/160 (16%)
		fn3	1150..1237	CDD:278470	18/91 (20%)
		FN3	1263..1345	CDD:238020	20/109 (18%)
		Ig	1350..1436	CDD:299845	22/90 (24%)
		IG_like	1358..1436	CDD:214653	20/82 (24%)
		FN3	1441..1530	CDD:238020	7/29 (24%)
		FN3	1542..1620	CDD:238020
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	17/72 (24%)
		IG_like	62..145	CDD:214653	16/70 (23%)
		FA58C	402..555	CDD:238014	39/215 (18%)
		FA58C	403..556	CDD:214572	39/215 (18%)
		Peptidase_M14_like	577..1036	CDD:299699	43/194 (22%)
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900