DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and hspg2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_021325650.1 Gene:hspg2 / 565429 ZFINID:ZDB-GENE-080807-4 Length:3701 Species:Danio rerio


Alignment Length:2276 Identity:465/2276 - (20%)
Similarity:751/2276 - (32%) Gaps:683/2276 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 GNG----TLHFPPFLAQYYRTDVHEATYRCR---ASNEAGTVLSRNVQVHAVVRRQFHVHVENTE 148
            |||    |...|.:|.||..        ||.   ..|....|..|:.....||:    |:.|..:
Zfish  1775 GNGGYQCTACQPGYLGQYCE--------RCAPGYVGNPQARVPCRSDAAFLVVK----VYPERVQ 1827

  Fly   149 VYLGNSALIKCAI----PEYV-------RPYVRVASWHR-GEEILLPDL-SDVAGRYVVLAASGD 200
            |..|....::|.:    |.|.       ||....|...| |||:..|.: |:.||.|:       
Zfish  1828 VAQGLPVTLRCQVSGSPPHYFQWSREDGRPISSSAERRRQGEELHFPGIQSNDAGVYI------- 1885

  Fly   201 LYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVER----- 260
                            |...:..:..|.:::.|:..:           ..||: |:.:|.     
Zfish  1886 ----------------CTCRDQRSSNRSKAEIVVATL-----------PSKPI-EVFIEEPKAQS 1922

  Fly   261 ---GNDVHLPCNIQGNPFPIFT--WYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWIC 320
               |:.|...|..: :..|.:|  |.|..:.    .:|:  |.:....:|.|:|....|||.::|
Zfish  1923 VRVGSTVSFICTAK-SKLPAYTLVWTRKGNG----KLPN--RAMDFNGILTIQNVQPEDAGIYVC 1980

  Fly   321 QASNQFG----------EQRIEIRLSVNSYVSVH--------------ILPQVQIVNSGGTANFN 361
            ..||..|          .:..:.::...:|....              :.|.||.|..|..|.|.
Zfish  1981 TGSNMLGMDEGSAVLYVPEASQSQMFYTAYEMFEGHRKPAEGVQPVATLSPPVQTVKEGDVAQFR 2045

  Fly   362 CTTTGSAIDAIDWL-HNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRAS 425
            ||.||:...|::|: .:||.:.:...:..|:          |.:.:|.|.|.|.|.|...|....
Zfish  2046 CTVTGNPTPAVEWIGGSGKRISSKAVIRNGQ----------LTISSVDRSDEGEYICKALNTHGE 2100

  Fly   426 AQAMAELKLGDT-----VPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAW-----LLDSQPIM 480
            ..|...|.:..|     :|.:..:.....:..|..:.|.|.|.|||.|...|     .|..|.|.
Zfish  2101 HTARGVLHVQSTGQPNGLPHVQVSPQRVEIYEGETLRLYCRAIGSPTPSLKWNKRGGSLPPQAIP 2165

  Fly   481 DVSLHHRFAIGQFVDMSGDV----------------ISHLNISHVRPDDGGLYKCVASNSMGSVQ 529
            ....|      ||...|.||                |..|.:.::|..|.|.|.||.:|:.||.:
Zfish  2166 SHGFH------QFKSNSLDVLQRRIEELQARMDRTDIGTLVVPNIRLSDAGTYLCVGTNAAGSSE 2224

  Fly   530 HSARLNV-----------YGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKA-------H 576
            ....::|           ..||      ....:.||.:.::|...|.....::|.:|       |
Zfish  2225 AHIDVSVTKGENILSGVIIQPP------SASVIEGEALDLNCLVPGTSTGSVKWSRAGGLLSSNH 2283

  Fly   577 QELTTSNHYELASVADGGQLV--IKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPV-IEP 638
            |.|.|......||..|.|..:  ::| .|...:...:..|.|.|        .|.:.:|.: |||
Zfish  2284 QVLETRLRILRASADDTGDYICTVEN-GPSPQKATVSVSVTSSA--------SLGLQTPIISIEP 2339

  Fly   639 FKFPKNLQEGGRAQITCAVSSGDMPIYFSWK-KDDSSIPSSLQITEKKEEFYSLLVFKDISARHS 702
            ..  ..:::|..|...|.|.:|..|:...|| .::..:|.::::....    |::...:..|::.
Zfish  2340 HS--AVVKQGESASFRCKVHNGAQPVRLEWKLTNNLPLPDNVKVGPDS----SIMTVTNAQAKNQ 2398

  Fly   703 GKYTCYASNAAAKVNYTAELQVRVAPRWRYEPM-DTAIMLGNTISINCEAEGYPIPTITWFKGQG 766
            |.|.|.|||.....:....|.||.:|:....|. ...:.:|:.|::.|:|.|.|.|::.|.:...
Zfish  2399 GTYRCVASNLYGMTHSIVSLIVRESPKAVVTPAGPVRVRVGDPINLECQAAGEPRPSVRWHRLDN 2463

  Fly   767 KGSKDFKPLSMRNHSLLLN--LATDNDEGYYMCQATN-------------EIGAGLKKTIRINVN 816
            ............:.|.::.  :|...|.|.|:|.|.|             |.|..:....|.:|.
Zfish  2464 NRKTMLSSTVPVDSSAIIQVLVARPEDSGTYVCSAQNNQGTTETRVEVFVEGGPQVPTVPRASVR 2528

  Fly   817 EPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQL 881
            ||.        |........||.|.|.|....||.|.:....:...:           |.||:.|
Zfish  2529 EPM--------IIVVEGSTATLHCDAHGFPKPTITWFKERSSLPWRH-----------KIVDNSL 2574

  Fly   882 TIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIF--EVGSRTVKLSWRRPFDGN 944
            .:.:..|.|||.|.|.|.|..|.:|..|.|.|    |||.:....  :|..|..::...:.....
Zfish  2575 ILPNVGRQDSGQYVCNATNHLGTSEVTIMLEV----DTPPYATSLPNDVSVRVGEVIRLQCLAHG 2635

  Fly   945 SPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATT 1009
            :|.|.|                     :|.  .||.|||||:..:..|..:.    :|....|.|
Zfish  2636 TPPLRY---------------------EWT--KINGSLPSTAQLQGGDLQIN----LAKENDAGT 2673

  Fly  1010 FLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGY 1074
            :  |..|.|::.:|                ||.:.|.|:    |.|.|  ::.|:          
Zfish  2674 Y--RCVASNKVGKS----------------EALAKVSVR----SSLSV--KVSPQ---------- 2704

  Fly  1075 TVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIF 1139
                                                          |.::|:.       ||..|
Zfish  2705 ----------------------------------------------VEVKALG-------SAVEF 2716

  Fly  1140 GTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKR 1204
            ...|:|                 .|:|.||:     .||::        |..|.|    |..|.|
Zfish  2717 TCAAKG-----------------GLQIEWLK-----EGGVL--------PPNHHI----KDGILR 2747

  Fly  1205 TSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISW 1269
            ..|||        .||..|    ||            |:.......|..:.|        :||..
Zfish  2748 IENLE--------QSNEGI----YT------------CRVTSQFEHAQDSAK--------LLIQA 2780

  Fly  1270 LTPKNRNGIISHYTVYSREAGRKGQAKTH-------MVRVDENGYP----VTFESRSLAENQMYE 1323
            |.....|...|..||.   .|...:.:.|       .||..:.|.|    |......|..:|::|
Zfish  2781 LPKVKINVRTSVQTVM---VGNSVEFECHAIGDPEPTVRWSKVGAPLPDHVEIRGNILRIDQVFE 2842

  Fly  1324 -----FWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRAR 1383
                 :..:|:..|| .|.:.|:   .|.::..:||:..:.....:|:..||.|:|.|.|.|...
Zfish  2843 SDSGQYRCTATNDVG-SEHSHVV---LNIQSLPQIAALPESKEVTIGSDAVLPCIASGYPVPTIT 2903

  Fly  1384 W--LTRDRPVTFSPFYEVTNEGN-LKIHRVEGSLSGNYTCTANNLFGSDE--IQYQVIAMKPPSA 1443
            |  :..|.|.      :...:|: |.:..|..|.:|.|.|||.|..|..|  .:..|.....|..
Zfish  2904 WSKVENDLPP------KCRQDGHALTVPVVTESDAGTYVCTAANKQGKVEAFTRLNVHERVMPYF 2962

  Fly  1444 PQIIVQYASADSIRVSWDA--------PDD-GGAPLQGYTISYH----TAGESWSITELL---PE 1492
            .|..:.|.:..:|:.|:.|        ||: .|..|....|.|:    |.|..:....||   ||
Zfish  2963 TQEPLSYLTLPTIKNSYKAFSIKITFRPDNVDGLILYAGMIIYNGQKKTTGADFISFGLLGGRPE 3027

  Fly  1493 NNAFTISG---------LKCGNQYIIKMSAHNMVGSGVASEE--INVWTKGKASQAPNANELIAT 1546
            ......||         :|.|..:.:.:..:...||.|...:  :|..::||........||...
Zfish  3028 FRFDVGSGMATIRYPTPIKLGEFHTVHLYRNQTQGSLVVDGQAPVNGTSQGKFKGLDLNEELFVG 3092

  Fly  1547 NATCVNL--KLSSWQNG--GCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLP--- 1604
            .....::  |.:..:.|  || |....|:    ||   .|:..|:..:.....|...|...|   
Zfish  3093 GYPNYSMLAKTAGLKTGFVGC-IKQLIIQ----GD---EVIFKDLDKSSTGVSNCPTCKDRPCQN 3149

  Fly  1605 --------AKWYQLR----ISATNDAGKTTEHYHFSTTNIDGITIPPPS---------------- 1641
                    |..|:..    .:.:|....::.|.|......|...|..||                
Zfish  3150 DGTCEDSVASLYKCTCKRGFTGSNCQHHSSLHCHTEACGPDATCINRPSGLGYDCRCHLGKSGNK 3214

  Fly  1642 -------------------VFPSENDLMNNL-----INSTNPTSGDWFA---TLIVVVIITVSII 1679
                               .:|...::.|:|     ....:|....:|:   .:.|...:.||::
Zfish  3215 CMDGTLITTPLFDGEDSYIAYPPLTNIHNDLRIEMEFKPMDPDGLMFFSGGKKMKVEDFVAVSMV 3279

  Fly  1680 TIALTIKHRRTLCGPIAEGYESRTL-------------PGDYKEDHENRRNQQVYSASPVKTVDK 1731
            ...:..::.......:....|..:|             .|....||.    :::..:||.|....
Zfish  3280 NGHVEFRYELGTGQAVLRSQEPVSLDQWHRVVAERLNKDGSLTVDHA----KEITRSSPGKAQGL 3340

  Fly  1732 GNESEMY-------EISPY-ATFS-----------VNGGRTG-APAKTPTRAVAA---QTPLDYT 1773
            ...:.||       :|.|. |..|           :||.:.. :.:.|.:||::.   .:|.|  
Zfish  3341 NIHTPMYLGGVPSMDILPKPANVSMLFDGCIGEVFINGKKVDLSYSFTESRAISQCNDDSPCD-- 3403

  Fly  1774 MQFKTFGHP--EGENLNATA---YPLLPSSGFG----HVKSKSSWHKQRYYNTEDESTLSKSMTI 1829
                  ..|  ......|||   |....:.|:.    .:..:|..|..:..|  ..|.::.....
Zfish  3404 ------RRPCLHAGTCMATAEYEYQCFCAEGYEGDRCEIVKESCRHSSQCQN--GGSCVNNHCVC 3460

  Fly  1830 VAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSN-----MPTYRVPCK------ 1883
            .||....|.:|   |:.:..|.|...:.....:|:.|..|..|.:     :|....|..      
Zfish  3461 PAGYSGRHCEK---GQESSFSEAMWSLEGSGGNDSPIEYSAYFHDNGYLALPKPMFPRSAPDSPE 3522

  Fly  1884 ------SSRSSDG---------RAVVDMFRPDSSTESNNDQGSPAPERRHNTPRHVLGMGMAMG- 1932
                  ::.|.||         ...:::.:..::.:...|||.         .:..:.:|:..| 
Zfish  3523 TIELEINTASKDGLILWQGVESAGALNLHKKHANIKELGDQGK---------GKDFISLGLQNGH 3578

  Fly  1933 ------LGGGGGGGVGGGNGPAEKRS----AGQRSRKHGSAAQQPSNQTLERRKCPGSSNSLDSE 1987
                  ||.|....|.|  .|...|.    ...|:.|||..  |....:::|.:..|.|..::::
Zfish  3579 LVFSYQLGSGEAQIVSG--EPVNDRQWHKITAVRTGKHGYL--QIDGGSVQRGQSQGKSIMVNTK 3639

  Fly  1988 VDAETAASLAASIAAMAGSGAGADLSG--------GFRPPAGFHDGREPGDHSDCEREQRALDLE 2044
            .:.....  |..:.|:.|....:.::|        ..||      |.:|.         |.:||:
Zfish  3640 GNIYLGG--APDMQALTGGKYSSGMTGCVKNLSLMNARP------GEQPA---------RPIDLQ 3687

  Fly  2045 V 2045
            |
Zfish  3688 V 3688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 13/48 (27%)
Ig 56..125 CDD:143165 11/40 (28%)
I-set 246..337 CDD:254352 23/110 (21%)
Ig 264..334 CDD:143165 18/81 (22%)
I-set 345..433 CDD:254352 25/88 (28%)
Ig 358..431 CDD:143165 20/73 (27%)
Ig 456..533 CDD:143165 28/97 (29%)
IGc2 553..619 CDD:197706 18/74 (24%)
I-set 634..724 CDD:254352 21/91 (23%)
ig 645..712 CDD:278476 16/67 (24%)
IG_like 734..815 CDD:214653 20/96 (21%)
Ig 745..815 CDD:299845 18/84 (21%)
I-set 820..913 CDD:254352 25/92 (27%)
Ig 838..920 CDD:299845 25/81 (31%)
FN3 917..1033 CDD:238020 24/117 (21%)
FN3 1040..1142 CDD:238020 13/101 (13%)
fn3 1150..1237 CDD:278470 20/86 (23%)
FN3 1263..1345 CDD:238020 22/97 (23%)
Ig 1350..1436 CDD:299845 25/90 (28%)
IG_like 1358..1436 CDD:214653 23/82 (28%)
FN3 1441..1530 CDD:238020 26/115 (23%)
FN3 1542..1620 CDD:238020 18/96 (19%)
hspg2XP_021325650.1 SEA 84..198 CDD:321958
LDLa 216..251 CDD:238060
LDLa 277..311 CDD:238060
LDLa 317..351 CDD:238060
LDLa 360..395 CDD:238060
Ig_Perlecan_like 413..490 CDD:143220
Laminin_B 598..732 CDD:306547
EGF_Lam 766..814 CDD:238012
EGF_Lam 831..869 CDD:238012
Laminin_EGF 871..923 CDD:278482
Laminin_B 991..1125 CDD:306547
Laminin_EGF 1159..1206 CDD:278482
EGF_Lam 1208..1261 CDD:238012
Laminin_EGF 1272..1315 CDD:278482
Laminin_B 1536..1671 CDD:306547
EGF_Lam 1705..1754 CDD:238012
EGF_Lam 1755..1811 CDD:238012 12/43 (28%)
IG_like 1823..1903 CDD:214653 20/102 (20%)
Ig_Perlecan_like 1911..1996 CDD:143231 21/92 (23%)
I-set 2025..2109 CDD:254352 26/93 (28%)
I-set 2119..2231 CDD:254352 30/117 (26%)
I-set 2241..2309 CDD:333254 16/73 (22%)
Ig_3 2333..2407 CDD:316449 19/79 (24%)
Ig_3 2427..2500 CDD:316449 16/72 (22%)
I-set 2517..2606 CDD:254352 29/107 (27%)
I-set 2610..2693 CDD:333254 24/127 (19%)
I-set 2699..2778 CDD:333254 32/209 (15%)
I-set 2785..2867 CDD:254352 19/88 (22%)
I-set 2871..2954 CDD:254352 25/88 (28%)
LamG 2961..3119 CDD:238058 34/158 (22%)
EGF_CA <3146..3175 CDD:238011 4/28 (14%)
LamG 3226..3377 CDD:238058 22/154 (14%)
EGF 3402..3433 CDD:306513 7/38 (18%)
EGF_CA 3441..3470 CDD:238011 6/30 (20%)
LamG 3497..3671 CDD:238058 31/188 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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