DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and CRTAM

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_062550.2	Gene:	CRTAM / 56253	HGNCID:	24313	Length:	393	Species:	Homo sapiens

Alignment Length:	161	Identity:	42/161 - (26%)
Similarity:	66/161 - (40%)	Gaps:	11/161 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 VNSGGTANFNCTTTGSAIDAIDWL-HNGKPLQANNALTTGRDNIRFLSKS----SLLVQNVGRRD 411
            |..|.|....|.|:.....::.|| .:|..:..|..........:.|..|    |:.|.||..:|
Human    28 VEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQD 92

  Fly   412 RGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGS-PPPQFAWLLD 475
            .|||:||..:...|.:.:..:.|......::...:.:.......:.|.||...| ||||..|||.
Human    93 EGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLG 157

  Fly   476 SQPIMDVS---LHHRFAIGQFVDMSGDVISH 503
            :.  |:||   ||.....|:..:.:..:|.|
Human   158 NS--MEVSGGTLHEFETDGKKCNTTSTLIIH 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	22/85 (26%)
		Ig	358..431	CDD:143165	19/77 (25%)
		Ig	456..533	CDD:143165	19/52 (37%)
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CRTAM	NP_062550.2	Ig	20..114	CDD:299845	22/85 (26%)
		IG_like	24..114	CDD:214653	22/85 (26%)
		Ig	121..207	CDD:299845	19/68 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..273
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..393
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q149L7	390..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910