DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and robo4

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:1572 Identity:289/1572 - (18%)
Similarity:475/1572 - (30%) Gaps:596/1572 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 GRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGP 454
            |:.::|    ..|:.|....|||.       ::|..::.::|:.|    |.:::...:..||.|.
Zfish    37 GKGHLR----HRLMHQRASHRDRA-------HRRKGSRLVSEINL----PRIVHHPSDVVVRVGS 86

  Fly   455 LISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKC 519
            ..:|.|.|.|:|.|...||.:.||:                                        
Zfish    87 PATLSCRAEGNPEPTIQWLRNGQPL---------------------------------------- 111

  Fly   520 VASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNH 584
                      .:.:::....|.                                           
Zfish   112 ----------DTDKMDAQSQPI------------------------------------------- 123

  Fly   585 YELASVADGGQLVIKNVEPGR----DQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKF-PKN 644
                 |...|.|...:|.|||    .:.:|.||..:..|....|:..|::.:  :.|.|:. |.:
Zfish   124 -----VLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAA--LREDFRVQPSD 181

  Fly   645 LQE--GGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTC 707
            ::.  |..|.|.|:...|......:|:||...|.||   .|...|....|:........||.|:|
Zfish   182 VEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSS---NEHYTELKGKLIIAPAQKNDSGVYSC 243

  Fly   708 YASN-AAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQG---KG 768
            .||| ...:.:..|.|.|...|....:|.|.::.||.:....|||:|.|:|:|.|.:.||   .|
Zfish   244 IASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSREQGPLPNG 308

  Fly   769 SKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRN 833
            .....|    :|||.::..|..|.|.|.|...|::|        ::|.......:.|.....|  
Zfish   309 RYLINP----DHSLQIHYVTAQDMGRYSCTVENKLG--------VSVASAQLLVEDAGGTRLR-- 359

  Fly   834 DPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIA 898
                 |.|.                 :|:..|.|:                              
Zfish   360 -----DLHK-----------------ELSALRVSL------------------------------ 372

  Fly   899 ENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSH 963
            ||                      :.:....|...::.|:....|:.|  .||..::.|     :
Zfish   373 EN----------------------VTVMSTASNMSQVMWKLQSFGSQP--HYLEGFEVL-----Y 408

  Fly   964 GSLAAAGGDWNGHVINVSLPST-----SISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERS 1023
            .||..|..||...  .|..||.     .:.|.|..:               |.:|....:...|.
Zfish   409 RSLLPASSDWTAQ--RVPQPSLHTHVGPLKRGYKYE---------------FKVRPYGSSLYGRE 456

  Fly  1024 AYTEAIVLKTQEEAPTEAPSNVQVQTGGE--SELIVTWQIPPRESWNGELIGYTVNCSEEKQNIN 1086
            :.|..  |:..|..|:.||.:|.:....|  ..:.::|:.||.::.||.:.||.|.|.|.::..:
Zfish   457 SNTRH--LRVPEIVPSAAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTS 519

  Fly  1087 FISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSG----PWSAAIFGTTAEGVP 1147
            |...|:|...|..:       .||...|   .|.||:.|:|..|.|    |:...|     |...
Zfish   520 FNWTVDSGTHSIEI-------FTLLPSR---LYWVTVAAVNGAGVGVQSDPYKLLI-----ESRL 569

  Fly  1148 EAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYL 1212
            ||.|..   |.:.|.|..:|.::.|: |.|.:                                 
Zfish   570 EATPYQ---TGILSMSHFVSVIKEPV-FIGSV--------------------------------- 597

  Fly  1213 HTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNG 1277
            .||                        |:|              ...:||..:....:.|.|.:|
Zfish   598 GTL------------------------LWC--------------VLMITAVFLYRRHIRPANPSG 624

  Fly  1278 IISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVG-EGEPTSVI 1341
                     :.:|        :.|::..  .:..:.|..|.:..   |:|.....| ..||...:
Zfish   625 ---------KSSG--------LYRLESE--DLIIKHRMAAPDSP---WISGGWRPGSNSEPKQGL 667

  Fly  1342 AQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNEGNLK 1406
            ...:...:..|..:....|:|.            .||...|..:..|....:..||.        
Zfish   668 WTPSQENSGLRRTTLPITVKKD------------PNPLRSAVPIVPDNCGVYGTFYV-------- 712

  Fly  1407 IHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQ 1471
                  .|:||...|.|:               |...|::                 ..|.:.||
Zfish   713 ------DLTGNGLKTFNS---------------PGRCPRM-----------------PHGNSQLQ 739

  Fly  1472 GYTISYHTAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQ 1536
            .        .|:..|||  |                |:|.:.       |...:...|.:...:|
Zfish   740 N--------SETIRITE--P----------------IVKTAV-------VRELQALPWKRTLPAQ 771

  Fly  1537 APNANELIATNATCVNLKLSSWQ-NGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFC 1600
             ||           :.:|..||: |....:|  :::..||..:              |::.|..|
Zfish   772 -PN-----------MGVKKESWEKNVKRELH--AVKSAPLMPL--------------NQQALAVC 808

  Fly  1601 DFLPAKWYQLRISATNDAGKTTE-----------HYHFSTTNIDGITIPPPSVFPSE-NDLMNNL 1653
            .   |..:|.|.| .:.||..:|           ||..|...:|.:..|||  .|.| |..:::.
Zfish   809 S---APNHQQRFS-QHPAGGVSEPVKPLSSPRILHYSASLQLVDMLPSPPP--LPMEDNHSLSSE 867

  Fly  1654 INSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQ 1718
            ..||..|.                   :.:.|..::::|.  |.|.:.   |........|..  
Zfish   868 DESTRSTK-------------------LTVDIGSQQSVCA--ASGLQG---PASANTGCPNNH-- 906

  Fly  1719 QVYSASPVKTVDKGNESEMYEISP-YATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGH- 1781
                 ||.            ::|| |:..|           |.:..::.....|.|:  .|.|| 
Zfish   907 -----SPA------------QLSPSYSHLS-----------TASFCLSTDDYQDTTL--STQGHT 941

  Fly  1782 --------PEGENLNATAYPLL-----PSSGFGHVKSKSSWHKQRYYNTEDE--------STLSK 1825
                    |:|::.:..:.|.:     |:...|::....    .|..:.|.|        :||..
Zfish   942 QYMEISPKPQGQSTSHQSTPSMPRPFSPTPTLGYICGPG----DREMDEEQETVPIGLRRATLRS 1002

  Fly  1826 SMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDG 1890
            :.:.......| |..:..|..::|:...:.....|.||.|......|:.:........|...|| 
Zfish  1003 TPSSCCSEWEG-SLWNGWGSVSESNVTSARTSIISSSDCSFINDANFARVLALTAESMSGNLSD- 1065

  Fly  1891 RAVVDMFRPDSS 1902
                  |.|.:|
Zfish  1066 ------FSPPAS 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 9/42 (21%)
Ig 358..431 CDD:143165 8/40 (20%)
Ig 456..533 CDD:143165 10/76 (13%)
IGc2 553..619 CDD:197706 10/69 (14%)
I-set 634..724 CDD:254352 26/93 (28%)
ig 645..712 CDD:278476 21/69 (30%)
IG_like 734..815 CDD:214653 26/83 (31%)
Ig 745..815 CDD:299845 22/72 (31%)
I-set 820..913 CDD:254352 9/92 (10%)
Ig 838..920 CDD:299845 7/81 (9%)
FN3 917..1033 CDD:238020 22/120 (18%)
FN3 1040..1142 CDD:238020 30/107 (28%)
fn3 1150..1237 CDD:278470 10/86 (12%)
FN3 1263..1345 CDD:238020 12/82 (15%)
Ig 1350..1436 CDD:299845 14/85 (16%)
IG_like 1358..1436 CDD:214653 13/77 (17%)
FN3 1441..1530 CDD:238020 12/88 (14%)
FN3 1542..1620 CDD:238020 15/78 (19%)
robo4XP_689255.3 Ig1_Robo 70..169 CDD:143317 29/200 (15%)
I-set 71..168 CDD:254352 28/194 (14%)
I-set 175..261 CDD:254352 25/88 (28%)
Ig2_Robo 177..261 CDD:143201 24/86 (28%)
I-set 265..350 CDD:254352 28/96 (29%)
Ig 282..350 CDD:299845 23/79 (29%)
FN3 373..448 CDD:214495 21/120 (18%)
FN3 472..560 CDD:238020 28/97 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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