DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and lrit3a

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	612	Identity:	119/612 - (19%)
Similarity:	196/612 - (32%)	Gaps:	212/612 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 ELIYTFIEQN----VRPGPLISLK----CSASGSPPPQFAW--LLDSQPIMDVSLHHR------- 487
            ||.|.:|..|    |.||...:||    ....|:....|.|  |.:...:..:.||:.
Zfish    82 ELRYLWITYNSITSVDPGSFYNLKVLHELRLDGNMIATFPWESLKEMPSLKTLDLHNNRLTSVPV 146

  Fly   488 ----FAIG-QFVDMSGDVISHL---------NISHVRPD------------------DGGLYKCV 520
                :.|. .::|:|.:.::.|         ..|.::|.                  |..:.|.:
Zfish   147 EAAPYLINITYLDISSNKLTTLPSDLVDIWPPFSGIQPSANTSQKTVLGLQDNPWYCDCRISKLI 211

  Fly   521 ASNSMGS---VQHSARLNVYGPPYV-----------RAIGP--------IKAVAGEDIIVHCPFA 563
            ..:.|..   |.....|...||.::           :.:.|        |.:..|.::::.|...
Zfish   212 ELSKMAGIPVVLMDQVLTCSGPEHLSGVLFQRAELDQCVKPTVMTSATKITSPLGSNVLLRCDAN 276

  Fly   564 GYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNV----EPG---------------RDQGI 609
            |:|...:.|                :.|||.  |:.|.    .||               :|.|.
Zfish   277 GFPTPTLLW----------------TTADGS--VVNNTVVQESPGEGVRWSILSLHSIVFKDAGD 323

  Fly   610 YTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSS 674
            |.|..::.|| .|...:.|:|:......||. |.|:.:....|.|...:...||::.|.
Zfish   324 YRCKAKNVAG-NAEAYITLSVDGVQPTTPFP-PINITKQPEDQPTTTFTPTKMPLFTSL------ 380

  Fly   675 IPSSLQITEKKEEFYSLLVFKDISARHSG------KYTCYASNAAAKVNYTAE----------LQ 723
              |.:.||.:.    .:.....::.|.|.      :.:..|.:..|||..:..          ..
Zfish   381 --SPITITTRP----VMTTMPPLTTRKSPIPGGGVQRSPPAGDKPAKVQQSKNGKGSIKKSDIRD 439

  Fly   724 VRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP---TITWFKGQGKGSKDFKPLSMRNHSLLLN 785
            :.|..    |..:||::|.:       |||.|..   |:.:|....|..|:.....:....|||.
Zfish   440 IEVVE----ETTETAVLLWS-------AEGLPSDTPLTVVYFPYDAKDDKETVDTEVGQGKLLLE 493

  Fly   786 LATDNDEGYYMCQATN-------------EIGA--GLKKTIRINVNEPARFEQSA---------- 825
            ....| :.|.:|..|.             |||.  |..|.:.|         .||
Zfish   494 YLMPN-QVYTVCLVTKSSGKEQCVDFSTLEIGGEEGQNKVLMI---------ASAIACAIAVPLI 548

  Fly   826 ------------RNISSRRNDP---VTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMK--- 872
                        :..|||.|.|   ::.|.:.| .|.:|:.....||:.:....|....|.:
Zfish   549 VVLLYKILCLYCKGNSSRNNGPDEDLSKDTYVK-FETLTMKQRTLNGQANDLWARRQTQESERML 612

  Fly   873 --TEKGVDSQLTI-GHSDRHDSGVYRC 896
              :...:|||:|. ..|.|.:   |.|
Zfish   613 LCSRSSIDSQMTYKSDSSRSE---YLC 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	18/124 (15%)
		IGc2	553..619	CDD:197706	16/84 (19%)
		I-set	634..724	CDD:254352	18/105 (17%)
		ig	645..712	CDD:278476	11/72 (15%)
		IG_like	734..815	CDD:214653	24/98 (24%)
		Ig	745..815	CDD:299845	21/87 (24%)
		I-set	820..913	CDD:254352	23/108 (21%)
		Ig	838..920	CDD:299845	16/65 (25%)
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	16/58 (28%)
		leucine-rich repeat	83..106	CDD:275378	8/22 (36%)
		LRR_4	107..145	CDD:289563	6/37 (16%)
		leucine-rich repeat	107..130	CDD:275378	4/22 (18%)
		LRR_8	129..>171	CDD:290566	6/41 (15%)
		LRR_4	129..170	CDD:289563	6/40 (15%)
		leucine-rich repeat	131..154	CDD:275378	2/22 (9%)
		leucine-rich repeat	155..168	CDD:275378	2/12 (17%)
		TPKR_C2	199..249	CDD:301599	7/49 (14%)
		Ig	252..343	CDD:299845	22/109 (20%)
		IG_like	261..343	CDD:214653	21/100 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900