DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and lrit1a

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	689	Identity:	138/689 - (20%)
Similarity:	238/689 - (34%)	Gaps:	209/689 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1196 FP---AKLEIKRT-------------SNLE------TYLHTLHKAS---NYSIRVLAYTATGDGL 1235
            ||   :||.|::|             ||||      ..|.:|:..|   .||:..|  ...|:.|
Zfish    57 FPGDTSKLRIEKTAIKRIPSEAFSYLSNLEFLWMSFNVLSSLNSDSFRGLYSLEEL--RLDGNSL 119

  Fly  1236 ASHPLFCQTDDDVPD---------------APAAIKAAALT------------ADSILISWLTPK 1273
            :|.|  .::..|:|.               :.||:....:|            ...:|.:|||.|
Zfish   120 SSFP--WESLMDMPSLRLLDIHNNQLSSLPSEAALYMKNITYLDLSSNNLLTVPAEVLNTWLTIK 182

  Fly  1274 NRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMY---EFWVSASTSVGE- 1334
            ...|               .::...::.:.:|.:        |.:.::|   :|..|.|.||..
Zfish   183 PTLG---------------AESSKLILGLHDNPW--------LCDCRLYDLVQFQKSPSLSVAFI 224

  Fly  1335 ------GEPTSVI------AQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWLTR 1387
                  .:|.|:.      |:....:.| |:.:....||.|||..::|.|..||.|.|...|...
Zfish   225 DTRLRCADPESLSGVLFSDAELRRCQGP-RVHTAVARVRSAVGNNVLLRCGTVGVPIPELAWRRA 288

  Fly  1388 D-RPVTFSPFYEVTNEG----NLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPP------ 1441
            | :|:..:...|.:.||    .|.:..|....:|.|.|.|.|..||.|....:|....|
Zfish   289 DGKPLNGTVLLENSKEGIVWSILSVPAVSYRDTGKYICKATNYAGSAEAVISLIINDAPKMENPT 353

  Fly  1442 ---------SAPQIIVQYASADSIRVSWDAP-DDGGAPLQGYTISYHTAGESWSITELLPENNAF 1496
                     ..|..:|:.|..:....::.:| ...|.||.| |:||         |...|
Zfish   354 LDPKPKLKSKKPNTMVKAAYQEKHIATYVSPTPKNGLPLSG-TVSY---------TGPYP----- 403

  Fly  1497 TISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNG 1561
               |::..|               .|:..:|       :|..:.:..:.||.:.:....||.|..
Zfish   404 ---GMESDN---------------AANSRMN-------TQTASPDGFLETNLSNLAANTSSLQQD 443

  Fly  1562 GCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRE--NLIFCDFLPAKWYQLRISATND----AGK 1620
            ...:.. |:  :.:||..:||..:..:...:|..  ::::..|......::.:|..|:    .|.
Zfish   444 PDRVVR-SV--KVIGDTDYTVCLNWRAPTAKNTTAFSVLYAVFGERDMRRINVSPGNNRIVIEGL 505

  Fly  1621 TTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVS-IITIALT 1684
            ..:..:.:...:.|:       .|.:...:  :.::....|.:....||.||:|||: :|.:.||
Zfish   506 VPKTKYIACVCVKGL-------IPKKEQCV--IFSTDAAASANGTQKLINVVVITVACVIAVPLT 561

  Fly  1685 IKHRRTLCGPIAE------GYESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPY 1743
            :   ...||.:..      |..|:.:...|          ..:......|..||.|.|..
Zfish   562 V---IVCCGALKRKIKKFLGKNSKDIQDSY----------VTFETLSPSTKAKGLEGEYL----- 608

  Fly  1744 ATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHP 1782
                     |...|:...|.::|::.||.....|..|.|
Zfish   609 ---------TRLNAEESNRLLSARSSLDSESTAKIEGQP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470	18/65 (28%)
		FN3	1263..1345	CDD:238020	17/97 (18%)
		Ig	1350..1436	CDD:299845	29/90 (32%)
		IG_like	1358..1436	CDD:214653	27/82 (33%)
		FN3	1441..1530	CDD:238020	18/104 (17%)
		FN3	1542..1620	CDD:238020	14/83 (17%)
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378	4/22 (18%)
		LRR_8	63..119	CDD:290566	15/57 (26%)
		LRR_RI	<77..175	CDD:238064	19/101 (19%)
		leucine-rich repeat	85..108	CDD:275378	5/22 (23%)
		LRR_8	108..167	CDD:290566	11/62 (18%)
		leucine-rich repeat	109..132	CDD:275378	6/26 (23%)
		leucine-rich repeat	133..156	CDD:275378	2/22 (9%)
		leucine-rich repeat	157..170	CDD:275378	1/12 (8%)
		LRRCT	199..243	CDD:214507	10/51 (20%)
		I-set	252..343	CDD:254352	29/91 (32%)
		Ig	259..333	CDD:299845	24/73 (33%)
		fn3	448..515	CDD:278470	10/69 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900