DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	730	Identity:	166/730 - (22%)
Similarity:	264/730 - (36%)	Gaps:	153/730 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 HLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAI--GPIKAV-AGEDIIVHC-PFA 563
            :|.|:.....|...|:|.|:.: ......|:|.|..||....|  ||:..: ||....:.| .|.
Human    84 NLEITDAELSDDASYECQATEA-ALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFN 147

  Fly   564 GYPVEQIRW--EKAHQELTTSNHYELASVADG------GQLVIK--NVEPGRDQGIYTCIVRSRA 618
            ..|...|.|  :...||...:: .||  :.||      .||:|.  :::.||   ::||...:.|
Human   148 AKPAATIIWFRDGTQQEGAVAS-TEL--LKDGKRETTVSQLLINPTDLDIGR---VFTCRSMNEA 206

  Fly   619 ---GEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQ 680
               |:|.  .::|:|:.||.:.....|:.:|||.|...||..::....:.:.|.|....|..:.:
Human   207 IPSGKET--SIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHE 269

  Fly   681 ITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTI 745
            ...:....||..         :...:|...|.....|.:..:.|..|||...:|..|...:|:.:
Human   270 SRYETNVDYSFF---------TEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDV 325

  Fly   746 SINCEAEGYPIPTITWFKGQGK------GSKDFKPLSMR----NHSLLLNLATDNDEGYYMCQA- 799
            ::.|...|.|..|:||.|....      ||.....||.:    ::.|||...|..|.|.|.|:|
Human   326 TLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTYTCRAI 390

  Fly   800 TNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCH-AKGDEPITIGWTQNNGRIDLNN 863
            ...||.. ::.:.:.||.|......|...:. |.|...::|. .....|..|.|......:::..
Human   391 VPRIGVA-EREVPLYVNGPPIISSEAVQYAV-RGDGGKVECFIGSTPPPDRIAWAWKENFLEVGT 453

  Fly   864 F-RFSIAEMKTEKGVDSQLTIGHSDRHDSGV-YRCIAENPYGRAEQIIFLAVQERPDTPSHLEIF 926
            . |:::....:..||.|.|||.:....|... |.|.|.|.:|....||.|  :||       |:.
Human   454 LERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL--EER-------EVL 509

  Fly   927 EVG---SRTVKLSWRRPFDGNSPVLSY----LVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPS 984
            .||   ..|:         |.|.:|.:    ||.:...:...|...:.....|.....:|.. |.
Human   510 PVGIIAGATI---------GASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE-PL 564

  Fly   985 TSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQT 1049
            |..|...|.       .|.::.||..   |:||    .|::.:.:.||......|       :.|
Human   565 TMHSDREDD-------TASVSTATRV---MKAI----YSSFKDDVDLKQDLRCDT-------IDT 608

  Fly  1050 GGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVN------------SSLKSTIVSG 1102
            ..|.|:        ::..||.   |.|...|::.:...:...:            .|.:.:..||
Human   609 REEYEM--------KDPTNGY---YNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSG 662

  Fly  1103 WATTKATLRG------------------------LRKYSRYAVTIRAMNSFGSGPW-SAAIFGTT 1142
            :|......||                        ...|..|       ..|.|.|: .||.:.|.
Human   663 YAQLNTYSRGPASDYGPEPTPPGPAAPAGTDTTSQLSYENY-------EKFNSHPFPGAAGYPTY 720

  Fly  1143 AEGVPEAAPQNVNCT 1157
            ..|.|:|.|..:..|
Human   721 RLGYPQAPPSGLERT 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	6/29 (21%)
		IGc2	553..619	CDD:197706	20/79 (25%)
		I-set	634..724	CDD:254352	16/89 (18%)
		ig	645..712	CDD:278476	12/66 (18%)
		IG_like	734..815	CDD:214653	25/91 (27%)
		Ig	745..815	CDD:299845	22/80 (28%)
		I-set	820..913	CDD:254352	23/95 (24%)
		Ig	838..920	CDD:299845	22/84 (26%)
		FN3	917..1033	CDD:238020	24/122 (20%)
		FN3	1040..1142	CDD:238020	21/138 (15%)
		fn3	1150..1237	CDD:278470	2/8 (25%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	8/32 (25%)
		Ig	25..116	CDD:299845	8/32 (25%)
		Ig2_KIRREL3-like	138..219	CDD:143236	22/88 (25%)
		I-set	223..304	CDD:254352	16/89 (18%)
		Ig_2	227..305	CDD:290606	15/86 (17%)
		Ig_2	311..405	CDD:290606	25/94 (27%)
		IG_like	314..405	CDD:214653	25/91 (27%)
		Ig5_KIRREL3	407..504	CDD:143306	24/99 (24%)
		IG_like	416..504	CDD:214653	22/90 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810