DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and SDK2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens


Alignment Length:1935 Identity:421/1935 - (21%)
Similarity:681/1935 - (35%) Gaps:547/1935 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 WICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQ 382
            |...|.:|....|.:.  .|:.|.....: :.|:...|......|...||......||||     
Human     7 WTLLALHQIRAARAQD--DVSPYFKTEPV-RTQVHLEGNRLVLTCMAEGSWPLEFKWLHN----- 63

  Fly   383 ANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIY--TF 445
             |..||      :|..:...::.::.|...|.|:|:|.|:      |..|....|..::.|  :|
Human    64 -NRELT------KFSLEYRYMITSLDRTHAGFYRCIVRNR------MGALLQRQTEVQVAYMGSF 115

  Fly   446 IE----QNVRPGPLISLKCSASGS-PPPQFAWLLDSQPI-----MDVSLHHRFAIGQFVDMSGDV 500
            .|    |:|..|....::.....| |.||..|..|.:.|     :.::|.:...|          
Human   116 EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVI---------- 170

  Fly   501 ISHLNISHVRPDDGGLYKCVASNSMGSVQHSARL-----NVYGP-----PYVRAIGPIK---AVA 552
                 :|.|.||.|..|....::..|..:.|..:     ||.||     |.:  |.|.|   .||
Human   171 -----LSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTI--IIPPKNTSVVA 228

  Fly   553 G-EDIIVHCPFAGYPVEQIR--WEKAHQELT--TSNHYELASVADGGQLVIKNVEPGRDQGIYTC 612
            | .::.:.|.....|:.::.  |:|....|:  .|:|        ..:|.|.| ..|.|.|.|.|
Human   229 GTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDH--------NRRLTIPN-PTGSDAGYYEC 284

  Fly   613 --IVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAV-----SSGDMPIYFSWKK 670
              ::||.:.....|...|:|..||     :|.|..:....|::...|     :.|..|...:|.|
Human   285 EAVLRSSSVPSVVRGAYLSVLEPP-----QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK 344

  Fly   671 DDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQV-RVAPRWRYEP 734
             |:::....::|..::.....|....:....:|.:.|:|.|||.:|..:..|.| .:||.....|
Human   345 -DAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 408

  Fly   735 MDTAIMLGNTISINCEAEGYPIPTITWFKGQ---GKGSKD---FKPLSMRNHSLLLNLATDNDEG 793
            :|:.::.|.::.:.||..|.|.|.|||.||:   ..||..   |.||  .:.|||::....:|.|
Human   409 LDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL--ESGSLLISPTHISDAG 471

  Fly   794 YYMCQATN-----EIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGW- 852
            .|.|.|||     |..|.|....|..:.:|.: :||.     .:....::.|....|..:||.: 
Human   472 TYTCLATNSRGVDEASADLVVWARTRITKPPQ-DQSV-----IKGTQASMVCGVTHDPRVTIRYI 530

  Fly   853 ---------TQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQI 908
                     |:::.||.|:.              :..|.|..:...|.|.|.|...:..|...:.
Human   531 WEKDGATLGTESHPRIRLDR--------------NGSLHISQTWSGDIGTYTCRVISAGGNDSRS 581

  Fly   909 IFLAVQERPDTPSH--LEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGG 971
            ..|.|::.|..|.|  ..:..|..|.:.|:|.:|||||||::.|:::            ::....
Human   582 AHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE------------MSENNA 634

  Fly   972 DWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAY---TEAIVLKT 1033
            .|...:.:|...:||::            |.||.||.::..|:.|:|::.:..:   ||.:.|  
Human   635 PWTVLLASVDPKATSVT------------VKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL-- 685

  Fly  1034 QEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVN-C------SEEKQNINFISVV 1091
            .||.||..|.||.........:::.||.||....||.|.||.:. |      ..:.:||....|.
Human   686 PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750

  Fly  1092 NSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNC 1156
            |..|:..|:               ::.|.:.:.|.||.|.|.:|:.:...|.:|||...|.||:.
Human   751 NLLLEDLII---------------WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHA 800

  Fly  1157 TALSSQSLKISWLEPPLQFHGGIIQGYKIL-YRPIVHQIDFPAKLEIKRTS---NLETYLHT--- 1214
            .|.:|.:::.:|..|..||..||.||||:: :.|...:       |:...:   |.:..:|.   
Human   801 EATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE-------EVTMVTARPNFQDSIHVGFV 858

  Fly  1215 --LHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNG 1277
              |.|.:.|...||.:|..|||..|.|...:|.:|||.....:..:.:...|:.:||..|..:||
Human   859 SGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG 923

  Fly  1278 IISHYTVYSREAGRKGQAKTHMVRVDENGYP-VTFESR--SLAENQMYEFWVSASTS-------- 1331
            |::.|.:...|..|.....||.:       | ||.|.|  .|.....|...|:|.||        
Human   924 ILTGYRISWEEYNRTNTRVTHYL-------PNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981

  Fly  1332 -----------------------------------------------------VGEGEPTSVIAQ 1343
                                                                 |||||...:|.|
Human   982 STISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQ 1046

  Fly  1344 ATN------------------------------------------TRAPARIASFGQVVRKAVGT 1366
            .:|                                          .:||..:|.....:|.|..|
Human  1047 LSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111

  Fly  1367 GLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTN-EGNLKIHRVEGSLSGNYT----------- 1419
            .|.|..:    |.|...:......|.:...|..:: .|....|.|:..:..:||           
Human  1112 SLWLRWM----PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYR 1172

  Fly  1420 --CTANNLFGSD---------------------------------------------------EI 1431
              ..|.|..||.                                                   ::
Human  1173 VQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237

  Fly  1432 QY-----------------------------------QVIAMK-----PPSAPQIIVQ------- 1449
            .|                                   ||:|..     .||.|.|:.:       
Human  1238 MYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG 1302

  Fly  1450 --------YASADSIRVSWDAPDDGGAPLQGYTISYH---TAGESWSITELLPENNAFTISGLKC 1503
                    .....|:|:.|..|......:..|.|::.   |...:.::..|.|....:|.:|||.
Human  1303 PPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKP 1367

  Fly  1504 GNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNG--GCS-I 1565
            .:.|:.:::|....|.|.|:|.:.|.|:.:....|.:..::..........|.||:.|  |.| :
Human  1368 ESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPV 1432

  Fly  1566 HHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKT--TEHYHFS 1628
            .:::|:.|.|...||.:.::.:|:   |..:.|.....|...|:.|:.||||.|.:  :|... |
Human  1433 RYYTIQTRELPSGRWALHSASVSH---NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE-S 1493

  Fly  1629 TTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCG 1693
            .|.:.......|::.........:::....|.:.|           .::.|.:...|::|..|  
Human  1494 LTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAED-----------KINGILLGFRIRYRELL-- 1545

  Fly  1694 PIAEGYESRTLPG--------------------------DYKEDHENRRNQQVYSASPVKTVDKG 1732
              .||....||.|                          .|:.|:.|:..:.....|....|.:|
Human  1546 --YEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG 1608

  Fly  1733 NESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHP---EGENLNATAYPL 1794
            ..|     .|...|......|.||.........| |.||.|.:      |   :.:|.:...|.:
Human  1609 PSS-----PPQEVFVGEAVPTAAPRNVVVHGATA-TQLDVTWE------PPPLDSQNGDIQGYKI 1661

  Fly  1795 LPSSGFGHVKSKSSWHKQRYYNTEDESTL--------SKSMT--------IVAGSQAGHSKKS-- 1841
            .            .|..||...||...||        .|::|        :.|.:.||...:|  
Human  1662 Y------------FWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714

  Fly  1842 NGGRSAKSSAACSGVVAGSE-SDTSISPSTEFSNMPT-----YRV---PC 1882
            ..|::.:::.:....|..|| :.||::.|.|....|.     ||:   ||
Human  1715 TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPC 1764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 4/18 (22%)
Ig 264..334 CDD:143165 4/15 (27%)
I-set 345..433 CDD:254352 20/87 (23%)
Ig 358..431 CDD:143165 18/72 (25%)
Ig 456..533 CDD:143165 17/82 (21%)
IGc2 553..619 CDD:197706 18/72 (25%)
I-set 634..724 CDD:254352 20/94 (21%)
ig 645..712 CDD:278476 12/71 (17%)
IG_like 734..815 CDD:214653 32/91 (35%)
Ig 745..815 CDD:299845 29/80 (36%)
I-set 820..913 CDD:254352 18/102 (18%)
Ig 838..920 CDD:299845 18/91 (20%)
FN3 917..1033 CDD:238020 30/120 (25%)
FN3 1040..1142 CDD:238020 26/108 (24%)
fn3 1150..1237 CDD:278470 28/95 (29%)
FN3 1263..1345 CDD:238020 30/145 (21%)
Ig 1350..1436 CDD:299845 22/185 (12%)
IG_like 1358..1436 CDD:214653 20/177 (11%)
FN3 1441..1530 CDD:238020 24/106 (23%)
FN3 1542..1620 CDD:238020 21/80 (26%)
SDK2NP_001138424.1 Ig 27..109 CDD:299845 23/100 (23%)
IG_like 40..109 CDD:214653 21/86 (24%)
I-set 120..203 CDD:254352 20/97 (21%)
Ig 132..210 CDD:299845 20/92 (22%)
IG_like 222..304 CDD:214653 23/90 (26%)
IGc2 233..286 CDD:197706 15/61 (25%)
I-set 308..397 CDD:254352 20/94 (21%)
Ig 326..394 CDD:143165 15/68 (22%)
I-set 402..492 CDD:254352 32/91 (35%)
Ig 416..492 CDD:299845 29/77 (38%)
Ig 502..586 CDD:299845 18/103 (17%)
IG_like 502..586 CDD:214653 18/103 (17%)
FN3 590..681 CDD:238020 27/114 (24%)
FN3 693..786 CDD:238020 26/107 (24%)
FN3 794..890 CDD:238020 30/102 (29%)
FN3 895..983 CDD:238020 24/94 (26%)
FN3 993..1087 CDD:238020 8/93 (9%)
FN3 1099..1194 CDD:238020 19/98 (19%)
FN3 1201..1290 CDD:238020 6/88 (7%)
FN3 1301..1394 CDD:238020 20/92 (22%)
FN3 1400..1484 CDD:238020 22/86 (26%)
FN3 1503..1616 CDD:238020 20/132 (15%)
FN3 1626..1719 CDD:238020 24/111 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 3/21 (14%)
FN3 1724..1805 CDD:238020 12/41 (29%)
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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