DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Hmcn1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_006529820.1	Gene:	Hmcn1 / 545370	MGIID:	2685047	Length:	5658	Species:	Mus musculus

Alignment Length:	2185	Identity:	469/2185 - (21%)
Similarity:	781/2185 - (35%)	Gaps:	575/2185 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 APRLLFGNDTGAQVT--------CTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFL 101
            ||..:.|.:....|.        |.:...|||.:.| |:||....:.||| .||.||::
Mouse  2125 APPNIMGEEQNVSVLIGQAVELFCQSDAVPPPTLMW-LKDGRPLLKRPGL-SISENGSV------ 2181

  Fly   102 AQYYRTDVHEA------TYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYL--GNSALIK 158
                 ..:.:|      .|.|.|:|.||.. .:|..|:..|....:...|..::..  ||...:.
Mouse  2182 -----LKIEDAQAGDTGRYTCEATNVAGKT-EKNYNVNVWVPPSIYGSDELVQLTAIEGNLITLL 2240

  Fly   159 CAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSED-GLMKFSCLVTNT 222
            |.......|.:   :|.:...::   |:|.|||..:|:....|.:......| ||  ::|:.:|.
Mouse  2241 CESSGIPPPDL---TWKKKGSLV---LADSAGRVHILSGGRRLQISIAEKADAGL--YTCVASNV 2297

  Fly   223 LNGERQRSDAVMLQVKELSKNLAPRTT----QKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRV 283
            ....::..:   |||     .:.|..|    .:|  ||.|.||..:.|.|.:||.|.|..||  :
Mouse  2298 AGVAKKEYN---LQV-----YIRPSITNSGGHRP--EITVIRGKSISLECEVQGIPQPTVTW--M 2350

  Fly   284 SDSAALYPIPSSQRV-ILSR-TLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVN---SYVSV 343
            .|..   |:...:.| ||.. .:|.:||....|.|:::|.|.|..|.......|||:   |.:..
Mouse  2351 KDGR---PLTKGKGVEILDEGRILQLKNVHVSDTGRYVCVAVNVAGMTDKRYDLSVHAPPSIIGN 2412

  Fly   344 HILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLL-VQNV 407
            |.:|:...|....:.:..|..:|..:.:|.||.:|.|:...:       :::.||...:| :...
Mouse  2413 HGVPENVSVVEKSSVSLTCEASGIPLPSITWLKDGWPVNLGS-------SVKILSGGRMLRLMQT 2470

  Fly   408 GRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIY---TFIEQNVRPGPLISLKCSASGSPPPQ 469
            ...|.|.|.|:|.|.....:.|..|.:  .||..|.   |..:..::....::|.|...|:|.||
Mouse  2471 RPEDAGQYTCIVRNAAGEDRKMFGLSV--LVPPHIVGENTLEDVKIKEKQSVTLTCEVRGNPVPQ 2533

  Fly   470 FAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARL 534
            ..|..|.|.:.:...||..:.|:|:.::...:||.          |.|.|:|||..|....|.||
Mouse  2534 ITWHKDGQLLQEDEAHHMMSGGRFLQITNAQVSHT----------GRYTCLASNIAGDKSKSFRL 2588

  Fly   535 NVYGPPYVRAIGPIKAVAG-------EDIIV--------HCPFAGYPVEQIRWEKAHQELTTSNH 584
            ||:..|         .:||       ||:||        .|....||...|.|.|....|.::.:
Mouse  2589 NVFVSP---------TIAGVDSDGSPEDVIVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRN 2644

  Fly   585 YELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIE------PFKFPK 643
            ..:  :..|..|.|.|.:.. :.|.|:|:..:.|||:.:. .::.|..||:|:      |...||
Mouse  2645 IRI--LPGGRTLQILNAQED-NAGRYSCVATNEAGEKIKH-YEVKVYIPPIIKKGDLLGPGLSPK 2705

  Fly   644 NLQEGGRAQITCAVSSGDMP-IYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTC 707
            .::....:.:|....:..:| ....|.||...:.|...:|.....  ..|..|:.....:|:|||
Mouse  2706 EVKIRVNSSLTLECEAYAIPSASLRWYKDGQPLKSDDHVTIAASG--HTLQIKEAQISDTGRYTC 2768

  Fly   708 YASNAAAKVNYTAELQVRVAPR----WRYEPM-DTA-------IMLGNTISINCEAEGYPIPTIT 760
            .|||.|.:.....::.::|.|.    |....| ||.       :::.|.:|::||....|.||:|
Mouse  2769 VASNLAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRSGEAKDVIINNPLSLHCETNAAPPPTLT 2833

  Fly   761 WFKGQGKGSKDFKPLSMRNHSLLL--------NLATDNDEGYYMCQATNEIGAGLKKTIRINVNE 817
            |:       ||.:||:..:..|:|        ..|...|.|.|.|.|.||.|   :.::|.:|:
Mouse  2834 WY-------KDGRPLTSSDRVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG---EDSLRYDVH- 2887

  Fly   818 PARFEQSARNISSRRNDPVT--------LDCHAKGDEPITIGWTQNNGRIDL--NNFRFSIAEMK 872
             .......:..:|...:.||        ::|.:.|: |....:.|.:|:|.|  .:.:|. ::.:
Mouse  2888 -VLLPPVIKGANSDLPEEVTVLVNKSTQMECSSSGN-PAPRNYWQKDGQILLEDEHHKFQ-SDGR 2949

  Fly   873 TEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDT--PSHLEIFEVGSRTVK- 934
            :.:.:::|:|       |:|.|.|:|||..|.|::...|.|...|..  |:|..:..|.:..:.
Mouse  2950 SLQILNAQIT-------DTGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPNHEHLSVVVNHFISL 3007

  Fly   935 -----------LSW---RRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVIN------ 979
                       |||   ..|...|:.||:    ....:.||...:..:.|||:....||
Mouse  3008 NCEVSGFPPPDLSWLKNEEPIKPNTNVLT----VPGGRTLQIIRAKISDGGDYTCIAINQAGESK 3068

  Fly   980 --VSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAP 1042
              ||| :..:..|......:|..:..:...|:..:      |.|.:|....::..::........
Mouse  3069 KKVSL-TVHVPPSIKDHGSQSLSIVNVREGTSVSL------ECESNAVPPPVITWSKNGRMIPDS 3126

  Fly  1043 SNVQVQTGGESELIVTWQIPPRESWNGELIGYTVN-CSEEKQNINFISVVNSSLKSTIVSGWATT 1106
            :||::.|||::..|...::    |..|:.:...:| ...:.:|.:    :|..:..||
Mouse  3127 TNVEILTGGQTLHIRRAEV----SDTGQYVCRAINVAGRDDKNFH----LNVYVPPTI------- 3176

  Fly  1107 KATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEP 1171
                                    .||.:..|..|.:.      |..:.|.|.......|:||:.
Mouse  3177 ------------------------EGPETEVIVETISN------PVTLTCDATGIPPPTITWLKN 3211

  Fly  1172 PLQFHGGIIQGYKILYRPI-------VHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYT 1229
                           ::||       ||.:...:||:|.|...        ..:.||:  .:|..
Mouse  3212 ---------------HKPIENSDPLEVHILSGGSKLQIARPQR--------SNSGNYT--CVASN 3251

  Fly  1230 ATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSI-LISWLTPKNRNGIISHYTVYSREAGRKG 1293
            ..|....:..||.|....|..|....:.:.|..::: |:.     |.:||.:.:..:.|:.....
Mouse  3252 MEGKAQKNFILFIQVPPSVAGAEVPSEVSVLLGENVELVC-----NADGIPTPHLQWLRDGKPIV 3311

  Fly  1294 QAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQ 1358
            ..:|..|||..:|..:.. .|:|. :.|.::...|:...||.:....:    |...|.:|....:
Mouse  3312 NGETERVRVTTDGSTLNI-YRALT-SDMGKYTCVATNPAGEEDRIFNL----NVYVPPKIRGNKE 3370

  Fly  1359 VVRK---AVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNEGN-LKIHRVEGSLSGNYT 1419
            ...|   .|.|.:.:||.|.|.|.|:..||....|:..|....:.:.|. ::|.|.:.|....||
Mouse  3371 EAEKLMALVDTSINIECKATGTPPPQINWLKNGLPLPISSHIRLLSAGQVVRIVRAQVSDIAVYT 3435

  Fly  1420 CTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESW 1484
            |.|:|..|.|...|.:....||:.                     |.....:..||   ..|.|.
Mouse  3436 CVASNRAGVDSKHYSLQVFVPPNM---------------------DNAMGTEEITI---VKGSST 3476

  Fly  1485 SITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNAT 1549
            |:|       .||                     .|..:..:: |.:.....||:|:..::|...
Mouse  3477 SMT-------CFT---------------------DGTPAPSMS-WLRDGQPLAPDAHLTVSTQGM 3512

  Fly  1550 CVNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISA 1614
            .:.|..:..::.|                ::|.|                              |
Mouse  3513 VLQLIKAETEDTG----------------KYTCV------------------------------A 3531

  Fly  1615 TNDAGKTTEHYHFSTTNIDGITIPPPSVFPSEND-----LMNNLINSTNPTSG------DWF--- 1665
            ||:||:.::|:...       .:.||.:..||..     ::||.:..:...||      .|.
Mouse  3532 TNEAGEVSKHFVLK-------VLEPPHINGSEGPGEVSVIVNNPLELSCIASGIPAPKISWMKDG 3589

  Fly  1666 ---------ATLIVVVIITVSIITIALTIKHRRTLCGPIAEG---YESR-----TLPG-DYKEDH 1712
                     .||....|:.||...:..|.::......|..:.   |..|     .:.| |..:|.
Mouse  3590 RPFLQTEQVQTLEGGAILRVSSAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGMDEAQDF 3654

  Fly  1713 ENRRNQQV-----YSASPVKTVDKGNESEMYEISPYATFSVNGGR--------TGAPAKTPTRA- 1763
            ...||:||     ..|.|...:......|..:.:|.... ::|||        .|..|.....|
Mouse  3655 TVLRNRQVTLECKSDAVPPPVIMWLKNREQLQATPRVRI-LSGGRYLQINNADLGDTANYTCVAS 3718

  Fly  1764 -VAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDES------ 1821
             :|.:|..::.:   |...|             ||.|.|.....:..:|........|.
Mouse  3719 NIAGKTTREFNL---TVNVP-------------PSIGGGPQSLVTLLNKSIALECRAEGVPAPRI 3767

  Fly  1822 TLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSR 1886
            |..|...::|.|.|.:|...||....:|:..         :||.             |..|.::.
Mouse  3768 TWRKDGVVLAESHARYSILENGFLHIESAHV---------TDTG-------------RYLCMATN 3810

  Fly  1887 -SSDGRAVVDM---------FRPDSSTESNNDQGSPAPERRHNTPRHVLGMGMAMGLGGGGGGGV 1941
             :...|..:|:         ..|.:.|.:.|.|.:.|.|              |.|:
Mouse  3811 VAGTDRRRIDLQVHVPPSIAMGPTNVTVTVNVQTTLACE--------------ATGI-------- 3853

  Fly  1942 GGGNGPAEKRSAGQRSRKHGSAAQQPSNQTLERRKCPGSSNSLDSEVDAETAASLAASIAAMAGS 2006
                   .|.|.  ..||:|.......||...|....||...:...||  ..||...::.
Mouse  3854 -------PKPSV--TWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVD--DTASYECTVT----- 3902

  Fly  2007 GAGADLSGGFRPPAGFHDGREPGDHSDCEREQRALDLEVQ 2046
                                     ||...::||:||.||
Mouse  3903 -------------------------SDAGEDKRAVDLTVQ 3917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	24/90 (27%)
		Ig	56..125	CDD:143165	23/82 (28%)
		I-set	246..337	CDD:254352	31/96 (32%)
		Ig	264..334	CDD:143165	22/71 (31%)
		I-set	345..433	CDD:254352	19/88 (22%)
		Ig	358..431	CDD:143165	17/73 (23%)
		Ig	456..533	CDD:143165	23/76 (30%)
		IGc2	553..619	CDD:197706	19/80 (24%)
		I-set	634..724	CDD:254352	22/96 (23%)
		ig	645..712	CDD:278476	15/67 (22%)
		IG_like	734..815	CDD:214653	28/96 (29%)
		Ig	745..815	CDD:299845	24/77 (31%)
		I-set	820..913	CDD:254352	23/102 (23%)
		Ig	838..920	CDD:299845	22/85 (26%)
		FN3	917..1033	CDD:238020	27/140 (19%)
		FN3	1040..1142	CDD:238020	16/102 (16%)
		fn3	1150..1237	CDD:278470	18/93 (19%)
		FN3	1263..1345	CDD:238020	16/82 (20%)
		Ig	1350..1436	CDD:299845	27/89 (30%)
		IG_like	1358..1436	CDD:214653	25/81 (31%)
		FN3	1441..1530	CDD:238020	11/88 (13%)
		FN3	1542..1620	CDD:238020	9/77 (12%)
Hmcn1	XP_006529820.1	vWFA	42..198	CDD:238119
		Ig	520..608	CDD:386229
		Ig	612..696	CDD:386229
		I-set	702..789	CDD:369462
		I-set	793..884	CDD:369462
		Ig	890..977	CDD:386229
		Ig	980..1071	CDD:386229
		I-set	1085..1167	CDD:369462
		I-set	1171..1257	CDD:369462
		Ig	1266..1354	CDD:386229
		I-set	1368..1447	CDD:369462
		IG_like	1459..1541	CDD:214653
		Ig	1564..1632	CDD:386229
		I-set	1644..1728	CDD:369462
		I-set	1751..1821	CDD:369462
		Ig	1843..1935	CDD:319273
		Ig	1949..2031	CDD:386229
		Ig	2044..2115	CDD:386229
		I-set	2134..2214	CDD:369462	25/93 (27%)
		I-set	2226..2309	CDD:369462	18/93 (19%)
		Ig_3	2313..2390	CDD:372822	28/83 (34%)
		Ig	2429..2491	CDD:319273	16/68 (24%)
		I-set	2501..2590	CDD:369462	27/98 (28%)
		I-set	2605..2686	CDD:369462	21/84 (25%)
		I-set	2704..2785	CDD:369462	19/82 (23%)
		Ig	2818..2881	CDD:319273	23/72 (32%)
		I-set	2902..2983	CDD:369462	22/89 (25%)
		I-set	3005..3075	CDD:369462	17/74 (23%)
		I-set	3087..3170	CDD:369462	15/96 (16%)
		Ig	3192..3260	CDD:319273	17/92 (18%)
		Ig	3267..3361	CDD:386229	20/104 (19%)
		I-set	3377..3453	CDD:369462	24/75 (32%)
		I-set	3468..3546	CDD:369462	24/162 (15%)
		IG_like	3558..3639	CDD:214653	13/80 (16%)
		I-set	3652..3732	CDD:369462	17/83 (20%)
		I-set	3736..3823	CDD:369462	21/108 (19%)
		Ig	3846..3912	CDD:319273	21/128 (16%)
		Ig	3937..4004	CDD:319273
		Ig	4028..4090	CDD:319273
		I-set	4102..4188	CDD:369462
		Ig	4209..4276	CDD:319273
		I-set	4283..4368	CDD:369462
		Ig	4387..4458	CDD:386229
		I-set	4463..4549	CDD:369462
		TSP1	4556..4607	CDD:214559
		TSP1	4612..4664	CDD:214559
		TSP1	4669..4721	CDD:214559
		TSP1	4726..4778	CDD:214559
		TSP1	4783..4835	CDD:214559
		TSP1	4840..4892	CDD:214559
		G2F	4891..5115	CDD:214774
		EGF_CA	5130..5169	CDD:214542
		EGF_CA	5170..5213	CDD:311536
		EGF_CA	5215..5252	CDD:214542
		EGF_CA	5253..5286	CDD:238011
		EGF_CA	5295..5336	CDD:311536
		EGF_CA	5338..5377	CDD:214542
		EGF_CA	5455..5494	CDD:214542
		EGF_CA	5495..5531	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910