DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Cntn3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_062202.1	Gene:	Cntn3 / 54279	RGDID:	3253	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1383	Identity:	285/1383 - (20%)
Similarity:	459/1383 - (33%)	Gaps:	431/1383 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KALLLGALLLAVLATPLLATSGLRVPTFLLEPAPRL--LFGNDTGAQVTCTAHGSPPPLVTWVLR 75
            |.|:| ...:..||..||    |:.|.|:.||:..:  :...|....:.|.|.|:|.|...|.|.
  Rat     6 KQLIL-LSFIGCLAGELL----LQGPVFVKEPSNSIFPVGSEDKKITLNCEARGNPSPHYRWQLN 65

  Fly    76 DGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQF 140
            ...:.|.:....|::|...:...|      ..:....:|:|.|:|..||::||..::.......|
  Rat    66 GSDIDTSLDHRYKLNGGNLIVINP------NRNWDTGSYQCFATNSLGTIVSREAKLQFAYLENF 124

  Fly   141 HVHVEN-TEVYLGNSALIKCAIPEYVRPYVRVASWHRGEEIL------LPDLSDVAGRYVVLAAS 198
            ...:.: ..|..|...::.|..|.           |.||...      .|...:...|..|...:
  Rat   125 KSRMRSRVSVREGQGVVLLCGPPP-----------HSGELSYAWVFNEYPSFVEEDSRRFVSQET 178

  Fly   199 GDLYVRSVRSEDGLMKFSCLVTNTLNGER---------QRSDAVMLQVKELSKNLAPRTTQKPVM 254
            |.||:..|...| :..::|:||:|:...|         .|||.||.:.:...:...|.|
  Rat   179 GHLYIAKVEPSD-VGNYTCVVTSTVTNARVLGSPTPLVLRSDGVMGEYEPKIELQFPET------ 236

  Fly   255 EIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWI 319
             :...:|:.|.|.|...|||.|...|.| ||.   .|.|:..::.....:|.|.|..:.|.|.:.
  Rat   237 -LPAAKGSTVKLECFALGNPVPQINWRR-SDG---MPFPTKIKLRKFNGVLEIPNFQQEDTGSYE 296

  Fly   320 CQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQAN 384
            |.|.|..|:.....||:.  |...:   .||::....||         ..|::.|
  Rat   297 CIAENSRGKNVARGRLTY--YAKPY---WVQLLKDVETA---------VEDSLYW---------- 337

  Fly   385 NALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQN 449

  Rat   338 ----------------------------------------------------------------- 337

  Fly   450 VRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDG 514
                     :|.|||.|.|.:.||.:...::   |..|..|    :.....|::||:|     |.
  Rat   338 ---------ECRASGKPKPSYRWLKNGDALV---LEERIQI----ENGALTIANLNVS-----DS 381

  Fly   515 GLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQEL 579
            |:::|:|.|..|.:..||.|.|
  Rat   382 GMFQCIAENKHGLIYSSAELKV------------------------------------------- 403

  Fly   580 TTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKN 644
                   |||..|..:                                         .|.|....
  Rat   404 -------LASAPDFSR-----------------------------------------NPMKKMIQ 420

  Fly   645 LQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYA 709
            :|.|....:.|..|:....:.| |||.|:.:....:|:...:....::   :::...:|.|||.|
  Rat   421 VQVGSLVILDCKPSASPRALSF-WKKGDTVVREQARISLLNDGGLKIM---NVTKADAGIYTCIA 481

  Fly   710 SNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTI--TW-FKGQGKGSKD 771
            .|...|.|.|.:|.|....|....|.:..:.:|.:|.:.|:.:..|:..|  .| |.|.   ..|
  Rat   482 ENQFGKANGTTQLVVTEPTRIILAPSNMDVAVGESIILPCQVQHDPLLDIMFAWYFNGT---LTD 543

  Fly   772 FKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPV 836
            ||                                          .:.:.||:
  Rat   544 FK------------------------------------------KDGSHFEK------------- 553

  Fly   837 TLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENP 901
                         :|.: ::|.:.:.|.:.                     :| ||.|.|:.:..
  Rat   554 -------------VGGS-SSGDLMIRNIQL---------------------KH-SGKYVCMVQTG 582

  Fly   902 YGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSL 966
            .........|.|:..|..|.::::.|:...|.:|||....|.:|||:||.||.:         :.
  Rat   583 VDSVSSAAELIVRGSPGPPENVKVDEITDTTAQLSWTEGTDSHSPVISYAVQAR---------TP 638

  Fly   967 AAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEI---ERSAYTEA 1028
            .:.|  |.    ||    .::..:.|...| :|.|..|.|...:..|:.|.|:|   |.|..:|.
  Rat   639 FSVG--WQ----NV----RTVPEAIDGKTR-TATVVELNPWVEYEFRVVASNKIGGGEPSLPSEK 692

  Fly  1029 IVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNS 1093
            :  :|:|.||..|||.|....|..|||::||...|.|..||...||.|
  Rat   693 V--RTEEAAPEVAPSEVSGGGGSRSELVITWDPVPEELQNGGGFGYVV----------------- 738

  Fly  1094 SLKSTIVSGWATTKATL----------RGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPE 1148
            :.:...|:.|..|..|.          ..:..:|.|.|.:...|:.|.||:|......:||..|.
  Rat   739 AFRPLGVTTWIQTVVTSPDNPRYVFRNESIVPFSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPT 803

  Fly  1149 AAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEI--KRTSNLETY 1211
            .||.:::..:|||..:::||...|.:...|.:.||::.|.....:.:..:|:::  .:||   ..
  Rat   804 VAPSHISAHSLSSSEIEVSWNTIPWKSSNGRLLGYEVRYWNNGGEEESSSKVKVAGNQTS---AV 865

  Fly  1212 LHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPK--N 1274
            |..|.....|...|.||...|.|..|..:...|....|..|........|...:|::|...|  .
  Rat   866 LRGLKSNLAYYTAVRAYNTAGAGPFSATVNATTKKTPPSQPPGNVVWNATDTKVLLNWEQVKALE 930

  Fly  1275 RNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAE-----NQMYEFWVSASTSVGE 1334
            ....::.|.|:.|.:             .:|...|...:::.||     .:.|...|.|:|..|:
  Rat   931 NESEVTGYKVFYRTS-------------SQNNVQVLNTNKTSAELLLPIKEDYIIEVKATTDGGD 982

  Fly  1335 GEPTSVIAQATNTRAPAR 1352
            |..:..|.....|...||
  Rat   983 GTSSEQIRIPRITSMDAR 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	19/76 (25%)
		Ig	56..125	CDD:143165	16/68 (24%)
		I-set	246..337	CDD:254352	27/90 (30%)
		Ig	264..334	CDD:143165	22/69 (32%)
		I-set	345..433	CDD:254352	6/87 (7%)
		Ig	358..431	CDD:143165	3/72 (4%)
		Ig	456..533	CDD:143165	22/76 (29%)
		IGc2	553..619	CDD:197706	4/65 (6%)
		I-set	634..724	CDD:254352	22/89 (25%)
		ig	645..712	CDD:278476	15/66 (23%)
		IG_like	734..815	CDD:214653	12/83 (14%)
		Ig	745..815	CDD:299845	10/72 (14%)
		I-set	820..913	CDD:254352	11/92 (12%)
		Ig	838..920	CDD:299845	11/81 (14%)
		FN3	917..1033	CDD:238020	32/118 (27%)
		FN3	1040..1142	CDD:238020	29/111 (26%)
		fn3	1150..1237	CDD:278470	23/88 (26%)
		FN3	1263..1345	CDD:238020	17/88 (19%)
		Ig	1350..1436	CDD:299845	2/3 (67%)
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Cntn3	NP_062202.1	Ig	25..114	CDD:299845	24/94 (26%)
		I-set	26..117	CDD:254352	24/96 (25%)
		Ig	120..214	CDD:299845	21/105 (20%)
		IG_like	130..205	CDD:214653	19/86 (22%)
		Ig	227..315	CDD:299845	27/100 (27%)
		IG_like	234..313	CDD:214653	26/89 (29%)
		I-set	318..403	CDD:254352	30/192 (16%)
		Ig	320..403	CDD:299845	30/187 (16%)
		I-set	408..496	CDD:254352	23/132 (17%)
		Ig	424..496	CDD:299845	19/75 (25%)
		IG_like	506..594	CDD:214653	23/181 (13%)
		Ig	515..598	CDD:299845	22/176 (13%)
		FN3	598..695	CDD:238020	32/118 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..714		12/31 (39%)
		FN3	703..795	CDD:238020	29/108 (27%)
		FN3	805..898	CDD:238020	24/95 (25%)
		FN3	906..991	CDD:238020	19/97 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910