DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and CNTN5

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001230199.1	Gene:	CNTN5 / 53942	HGNCID:	2175	Length:	1100	Species:	Homo sapiens

Alignment Length:	1307	Identity:	286/1307 - (21%)
Similarity:	465/1307 - (35%)	Gaps:	381/1307 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PTFLLEPAPRLLFGNDTGAQ---VTCTAHGSPPPLVTWV---------------LRDGSLATQVP 84
            |.|:.|| ..::|..|:..:   :.|...|:|.|...|:               |.||:.....|
Human    99 PVFVQEP-DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNP 162

  Fly    85 GLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVEN-TE 148
            ...|.||:                     |:|.|:|..|::|||...:.......|.....: ..
Human   163 SEAKDSGH---------------------YQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVS 206

  Fly   149 VYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLM 213
            |..|...::.|:.|.: .|.: :.||...|   .|.......|..:...:|:||:..|::.| :.
Human   207 VREGQGVVLMCSPPPH-SPEI-IYSWVFNE---FPSFVAEDSRRFISQETGNLYISKVQTSD-VG 265

  Fly   214 KFSCLVTNTLNGER---------QRSDAVMLQVKELSKNLAPRTTQKPVMEIH------VERGND 263
            .:.|||.||:...|         .|:|.||.:             .:|.:|:|      ..:|..
Human   266 SYICLVKNTVTNARVLSPPTPLTLRNDGVMGE-------------YEPKIEVHFPFTVTAAKGTT 317

  Fly   264 VHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGE 328
            |.:.|...|||.|..||.:|:..     |||..|:..|:.:|.|.|....|||.:.|:|.|..|:
Human   318 VKMECFALGNPVPTITWMKVNGY-----IPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGK 377

  Fly   329 QRIEIRLSVNSYVS-VHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRD 392
            .....:|.|.:|.. |..|...|: :||....:.|..||.......||.||.||...:.:.
Human   378 NSFRGQLQVYTYPHWVEKLNDTQL-DSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVE---- 437

  Fly   393 NIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLIS 457
                :....|::.||.:.|.|:||||.||:..:..|.||||:..:.|    ||....::...:::
Human   438 ----MVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP----TFALNQLKKTIIVT 494

  Fly   458 ------LKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGL 516
                  ::|...|||.|..:|....:.:.:   :.|.||  ..|.|      |.|.:....|.|.
Human   495 KDQEVVIECKPQGSPKPTISWKKGDRAVRE---NKRIAI--LPDGS------LRILNASKSDEGK 548

  Fly   517 YKCVASNSMGSVQHSARLNVYGPPYVRAIGP--IKAVAGEDIIVHCPFAGYPVEQIRWEKAHQEL 579
            |.|...|..||.:..|.|:|..|..:. :.|  .:...||.|:::|
Human   549 YVCRGENVFGSAEIIASLSVKEPTRIE-LTPKRTELTVGESIVLNC------------------- 593

  Fly   580 TTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVI--EPFKFP 642
                                                     :|..|..|:|.....:  :|..|.
Human   594 -----------------------------------------KAIHDASLDVTFYWTLKGQPIDFE 617

  Fly   643 KNLQEGGRAQ-ITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYT 706
               :|||..: |....||.|                              |:.::|...|:|:|.
Human   618 ---EEGGHFESIRAQASSAD------------------------------LMIRNILLMHAGRYG 649

  Fly   707 CYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKD 771
            |.....|..|:..|||.||..|    .|....|:...|.|         ..|::|
Human   650 CRVQTTADSVSDEAELLVRGPP----GPPGIVIVEEITES---------TATLSW---------- 691

  Fly   772 FKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPV 836
             .| :..|||.:                                        |:.|:.:|
Human   692 -SP-AADNHSPI----------------------------------------SSYNLQAR----- 709

  Fly   837 TLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENP 901
                     .|.::|| |....:.    .....:|::...||....:.:.       :|.:|.||
Human   710 ---------SPFSLGW-QTVKTVP----EIITGDMESAMAVDLNPWVEYE-------FRVVATNP 753

  Fly   902 YGRAEQIIFLAVQERPDTPSHL----------EIFEVGSRT-----VKLSWRRPFDGNSPVLSYL 951
            .|..:          |.|||.:          ....|..|:     :.::|       .||....
Human   754 IGTGD----------PSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAW-------EPVSEEF 801

  Fly   952 VQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQA 1016
            ...:...|:.:.......|  |...::..|..|..|.|.      ||     :.|.|.|.:::..
Human   802 QNGEGFGYIVAFRPNGTRG--WKEKMVTSSEASKFIYRD------ES-----VPPLTPFEVKVGV 853

  Fly  1017 INEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESW---NGELIGYTVNC 1078
            .|......:::.:|:.:.|..|:.||::|:..:...||::|.|: ..:||.   .|..:||..:.
Human   854 YNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWK-HIKESLGRPQGFEVGYWKDM 917

  Fly  1079 SEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTA 1143
            .:|            ....|:.:....:...|.||...:.|..|:||.|..|.||.|:.:..||.
Human   918 EQE------------DTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTK 970

  Fly  1144 EGVPEAAPQNVNCTALSSQSLKISWLEP--PLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTS 1206
            :..|..||.|:......|| :.:.| ||  ||.....:: |||:.||...|     :..::..|.
Human   971 KSPPSQAPSNLRWEQQGSQ-VSLGW-EPVIPLANESEVV-GYKVFYRQEGH-----SNSQVIETQ 1027

  Fly  1207 NLETYLHTLHKASNYSIRVLAYTATGDGLASH----PLFCQTDDDVPDAPAAIKAAALTADSI-- 1265
            .|:..: .|..|..|.|.|.||:..|||.||.    |.:  :...:..|.:.:.:.:.::.|:
Human  1028 KLQAVV-PLPDAGVYIIEVRAYSEGGDGTASSQIRVPSY--SGGKITSAQSTLHSLSTSSSSVTL 1089

  Fly  1266 LISWLTP 1272
            |::.:.|
Human  1090 LLALMIP 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	20/94 (21%)
		Ig	56..125	CDD:143165	17/86 (20%)
		I-set	246..337	CDD:254352	29/96 (30%)
		Ig	264..334	CDD:143165	24/69 (35%)
		I-set	345..433	CDD:254352	27/87 (31%)
		Ig	358..431	CDD:143165	21/72 (29%)
		Ig	456..533	CDD:143165	20/82 (24%)
		IGc2	553..619	CDD:197706	4/65 (6%)
		I-set	634..724	CDD:254352	20/92 (22%)
		ig	645..712	CDD:278476	13/67 (19%)
		IG_like	734..815	CDD:214653	10/80 (13%)
		Ig	745..815	CDD:299845	7/69 (10%)
		I-set	820..913	CDD:254352	15/92 (16%)
		Ig	838..920	CDD:299845	13/81 (16%)
		FN3	917..1033	CDD:238020	23/130 (18%)
		FN3	1040..1142	CDD:238020	26/104 (25%)
		fn3	1150..1237	CDD:278470	28/88 (32%)
		FN3	1263..1345	CDD:238020	3/12 (25%)
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CNTN5	NP_001230199.1	Ig1_Contactin-5	98..191	CDD:143256	26/113 (23%)
		I-set	99..190	CDD:254352	26/112 (23%)
		Ig	193..287	CDD:299845	22/99 (22%)
		IG_like	205..278	CDD:214653	20/78 (26%)
		Ig	300..387	CDD:299845	29/91 (32%)
		I-set	300..386	CDD:254352	29/90 (32%)
		I-set	390..475	CDD:254352	29/93 (31%)
		Ig	392..475	CDD:299845	29/91 (32%)
		I-set	489..568	CDD:254352	22/89 (25%)
		Ig5_Contactin_like	496..568	CDD:143170	22/82 (27%)
		I-set	573..667	CDD:254352	29/187 (16%)
		Ig	587..671	CDD:299845	29/176 (16%)
		FN3	671..768	CDD:238020	30/197 (15%)
		FN3	776..868	CDD:238020	18/111 (16%)
		FN3	878..969	CDD:238020	26/103 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..982		9/22 (41%)
		FN3	977..1062	CDD:238020	30/93 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910