DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and Cdon

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_059054.2 Gene:Cdon / 50938 RGDID:708433 Length:1256 Species:Rattus norvegicus


Alignment Length:1360 Identity:283/1360 - (20%)
Similarity:453/1360 - (33%) Gaps:409/1360 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 IDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQ---------RASAQ 427
            |.||||||.|..|.      :.|: :.:.:|.:.::.....|.|||:..|.         ..||.
  Rat    58 ISWLHNGKRLDRNT------EQIK-IHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAA 115

  Fly   428 AMAELKLGDTVPELIYTFIEQNV--------RPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSL 484
            |:|:.   |:....:.|..|:|.        ...|...::....|.      ||:          
  Rat   116 ALADF---DSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGK------WLM---------- 161

  Fly   485 HHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGS---VQHSAR-----------LN 535
               ::.|.::.:....:..||:|   ..|.|.|||.|.|.:.|   |:.:.|           .:
  Rat   162 ---YSTGNYIILPSGNLQILNVS---SKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDGFH 220

  Fly   536 VYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQE-LTTSNHYELASVADGGQLVIK 599
            :..|...:|:.   .:....:.:.|..:|.|..|:.|.|..|: |:.||...|.|     .|...
  Rat   221 ILHPALSQALA---VLPHSPVTLECVVSGVPASQVYWLKDGQDALSGSNWRRLYS-----HLATA 277

  Fly   600 NVEPGRDQGIYTCIV-RSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQE-----GGRAQITCAVS 658
            :::|. |.|.|:|:| .:|:|:.  :.:...||   |:|.....|.|.:     |...:.||.|.
  Rat   278 SIDPA-DSGNYSCVVGNNRSGDV--KHVTYTVN---VLEHASISKGLHDQKVSLGATVRFTCEVH 336

  Fly   659 SGDMPIYFSWKKDDSSI-PSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAEL 722
            ....| ..:|..:...| |||..:||.     |:|....:....||.|.|.|.|....:..|..|
  Rat   337 GNPAP-NRTWFHNAQPIRPSSRHLTEG-----SVLKITGVIMEDSGLYQCMADNGIGFMQSTGRL 395

  Fly   723 QVRVAPRWR----YEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQG----------------- 766
            |:......|    ..|.:..:..|:.::::|.|.|.|:|.|.|:...|                 
  Rat   396 QIEQDSGQRPVIVTAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKS 460

  Fly   767 ----KGSKDFKPLSM-----RNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFE 822
                .|..|.:|:.:     .:.||.:...|....|.|.|:|.|:.|:                .
  Rat   461 HLFRPGDLDPEPVYLIMSQAGSSSLSIQAVTWEHAGKYTCEAVNKHGS----------------T 509

  Fly   823 QSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSD 887
            ||...::     .|..:.:.|. ||:|......|...|..:        .:|.|:   |.:....
  Rat   510 QSEAFLT-----VVPFETNTKA-EPVTPSEASQNDERDPRD--------GSESGL---LNLFPVK 557

  Fly   888 RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTP-------SHLEIFEVGSRTVKLSWRRPFDGNS 945
            .|..||     |.|..:...:        ||.|       :|:      ..|..|.||...||..
  Rat   558 VHSGGV-----ELPAEKNASV--------PDAPNILSPPQTHM------PDTYTLVWRAGRDGGM 603

  Fly   946 PVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINV--SLPSTSISRSYDSDLRE------SAIVA 1002
            |:.:|.|:|:.|    ..||  .|.|.|  |.:.|  |.....::....|.|.|      ||:..
  Rat   604 PINAYFVKYRKL----DDGS--GAVGSW--HTVRVPGSESELHLTELEPSSLYEVLMVARSAVGE 660

  Fly  1003 GLTPATTF---------------------LIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQ 1046
            |.....||                     :.:....:|...|.:...:...::.....|||....
  Rat   661 GQPAMLTFRTSKEKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPT 725

  Fly  1047 VQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGW-------- 1103
            :....|:.:.|||  .||.:....:..:.|   |.|:           :||   |.|        
  Rat   726 ISMASETSVYVTW--IPRANGGSPITAFKV---EYKR-----------MKS---SDWLVAAEDIP 771

  Fly  1104 -ATTKATLRGLRKYSRYAVTIRAMNSFG-------SGPWSAAIFGTTAEGVPEAAPQNVNCTALS 1160
             :.....:|.|...|.|...:.|:|.:|       |.|:..|.|.......|...|......|:|
  Rat   772 PSKLSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVS 836

  Fly  1161 SQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRV 1225
            ...:.:.|...|...:...|||:.|.|||.....|...|.::...|.....:..|...::|.|::
  Rat   837 DTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKM 901

  Fly  1226 LAYTATGDGLASHPLFCQTD-DDVPDA----------------------PAAIKAAALTADSI-- 1265
            ..:...|:...|:.:.|:|. ..||.|                      ||.  :.|.::|.:  
  Rat   902 QCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPAT--SPARSSDMLYL 964

  Fly  1266 ------------------LISWLTPKNR--------------------NGIISHYTVYSREA--- 1289
                              |..|   |:|                    ||.:..||..|..|   
  Rat   965 IVGCVLGVMVLILLVFIALCLW---KSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGTARIN 1026

  Fly  1290 ----------GRKGQAKTHMVRVDENG-------------YPVTFES--RSLAENQMYEFWVSAS 1329
                      |......:|:.....||             |.....|  |:..|.:.....|:..
  Rat  1027 GSVHGGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSLTRTCVEFEHPHHLVNGG 1091

  Fly  1330 ---TSVGEGEPTSVI-----------AQATNTRAPA--RIASFGQ---------VVRKAV----- 1364
               |:|.:.:|...|           ...||:..|.  .:||:.|         |::..|     
  Rat  1092 AVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQDGLEMKPLGVMKFPVCPVST 1156

  Fly  1365 ---GTGLVLECL--AVGNPTPRARWLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANN 1424
               |..:..|||  :|. |.|..|...:|..   |.....:.|...:.:|.:.|           
  Rat  1157 VPDGGQIPEECLKDSVA-PAPTQRTCRQDNT---SDINSDSTEDTAEFNRGDSS----------- 1206

  Fly  1425 LFGSDEIQYQVIAMKPPSAPQIIVQYASAD-SIRVSWDAPDDGGAPLQGYTISYHTAGES 1483
              |..|.:.:|.:..|     :|:.....| |.:.:|..|   |.||.|.::....|.|:
  Rat  1207 --GHSEAEDKVFSWSP-----LILSPVLEDCSEKTAWSPP---GPPLDGLSVVLQQAQET 1256

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 20/69 (29%)
Ig 358..431 CDD:143165 19/67 (28%)
Ig 456..533 CDD:143165 16/79 (20%)
IGc2 553..619 CDD:197706 20/67 (30%)
I-set 634..724 CDD:254352 26/95 (27%)
ig 645..712 CDD:278476 20/72 (28%)
IG_like 734..815 CDD:214653 22/106 (21%)
Ig 745..815 CDD:299845 20/95 (21%)
I-set 820..913 CDD:254352 17/92 (18%)
Ig 838..920 CDD:299845 16/81 (20%)
FN3 917..1033 CDD:238020 33/151 (22%)
FN3 1040..1142 CDD:238020 27/117 (23%)
fn3 1150..1237 CDD:278470 19/86 (22%)
FN3 1263..1345 CDD:238020 24/163 (15%)
Ig 1350..1436 CDD:299845 21/106 (20%)
IG_like 1358..1436 CDD:214653 18/96 (19%)
FN3 1441..1530 CDD:238020 11/44 (25%)
FN3 1542..1620 CDD:238020
CdonNP_059054.2 Ig 28..113 CDD:416386 16/61 (26%)
Ig strand A 28..31 CDD:409353
Ig strand B 45..52 CDD:409353
Ig strand C 57..62 CDD:409353 2/3 (67%)
Ig strand C' 65..67 CDD:409353 1/1 (100%)
Ig strand D 73..77 CDD:409353 1/4 (25%)
Ig strand E 79..83 CDD:409353 1/3 (33%)
Ig strand F 92..100 CDD:409353 4/7 (57%)
Ig strand G 103..113 CDD:409353 0/9 (0%)
Ig 120..196 CDD:416386 19/100 (19%)
Ig strand A 120..123 CDD:409353 1/5 (20%)
Ig strand B 133..144 CDD:409353 1/10 (10%)
Ig strand C 149..155 CDD:409353 0/5 (0%)
Ig strand C' 157..160 CDD:409353 1/8 (13%)
Ig strand D 167..171 CDD:409353 0/3 (0%)
Ig strand E 173..179 CDD:409353 0/5 (0%)
Ig strand F 185..194 CDD:409353 5/8 (63%)
IGc2 236..294 CDD:197706 19/63 (30%)
Ig strand B 238..242 CDD:409353 0/3 (0%)
Ig strand C 251..255 CDD:409353 1/3 (33%)
Ig strand F 286..291 CDD:409353 2/4 (50%)
Ig strand G 300..303 CDD:409353 0/2 (0%)
Ig 320..397 CDD:416386 22/82 (27%)
Ig strand A' 320..324 CDD:409353 0/3 (0%)
Ig strand B 327..337 CDD:409353 3/9 (33%)
Ig strand C 342..348 CDD:409353 1/5 (20%)
Ig strand C' 349..352 CDD:409353 0/2 (0%)
Ig strand E 363..369 CDD:409353 2/5 (40%)
Ig strand F 376..384 CDD:409353 4/7 (57%)
Ig strand G 387..397 CDD:409353 2/9 (22%)
I-set 405..517 CDD:400151 24/132 (18%)
Ig strand A' 413..417 CDD:409353 0/3 (0%)
Ig strand B 421..429 CDD:409353 1/7 (14%)
Ig strand C 435..457 CDD:409353 3/21 (14%)
Ig strand C' 460..463 CDD:409353 0/2 (0%)
Ig strand D 471..479 CDD:409353 1/7 (14%)
Ig strand E 482..488 CDD:409353 2/5 (40%)
Ig strand F 496..504 CDD:409353 4/7 (57%)
Ig strand G 507..517 CDD:409353 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 522..550 7/36 (19%)
fn3 588..663 CDD:394996 25/82 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..696 0/24 (0%)
FN3 718..808 CDD:238020 23/108 (21%)
FN3 833..920 CDD:238020 20/86 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 929..952 0/22 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1212 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1256 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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