DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and NTM

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001338930.1	Gene:	NTM / 50863	HGNCID:	17941	Length:	367	Species:	Homo sapiens

Alignment Length:	357	Identity:	84/357 - (23%)
Similarity:	139/357 - (38%)	Gaps:	65/357 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   641 FPK-----NLQEGGRAQITCAVSSGDMPIYFSW---------KKDDSSIPSSLQITEKKEEFYSL 691
            |||     .:::|..|.:.|.:.:....:  :|         ..|...:...:.:....:..||:
Human    38 FPKAMDNVTVRQGESATLRCTIDNRVTRV--AWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100

  Fly   692 LVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPI 756
            .: :::.....|.|||..............|.|:|:|:......|.:|..||.||:.|.|.|.|.
Human   101 EI-QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164

  Fly   757 PTITWF----KGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE 817
            ||:||.    |..|..|:|        ..|.:...|....|.|.|.|:|::.|.:.:.:::.||.
Human   165 PTVTWRHISPKAVGFVSED--------EYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNY 221

  Fly   818 PARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVD---- 878
            |. :...|:..........||.|.|.........|.:::.|:           ::.:|||.
Human   222 PP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRL-----------IEGKKGVKVENR 274

  Fly   879 ---SQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLS-WRR 939
               |:|...:...||.|.|.|:|.|..|.....|.|.....|.:.:.|:  ||  :|..|: |:.
Human   275 PFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTLLQ--EV--KTTALTPWKG 335

  Fly   940 P------FDGNSP------VLSYLVQYQALKY 959
            |      .:|.|.      :|..||.:..||:
Human   336 PGAVSEVSNGTSRRAGCVWLLPLLVLHLLLKF 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	15/96 (16%)
		ig	645..712	CDD:278476	11/75 (15%)
		IG_like	734..815	CDD:214653	26/84 (31%)
		Ig	745..815	CDD:299845	22/73 (30%)
		I-set	820..913	CDD:254352	22/99 (22%)
		Ig	838..920	CDD:299845	21/88 (24%)
		FN3	917..1033	CDD:238020	15/56 (27%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
NTM	NP_001338930.1	Ig	44..132	CDD:416386	12/90 (13%)
		Ig strand A'	44..49	CDD:409353	0/4 (0%)
		Ig strand B	51..59	CDD:409353	2/7 (29%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	1/7 (14%)
		Ig strand C	64..70	CDD:409353	1/7 (14%)
		CDR2	71..83	CDD:409353	1/11 (9%)
		Ig strand C'	72..76	CDD:409353	0/3 (0%)
		Ig strand C'	80..83	CDD:409353	1/2 (50%)
		FR3	84..118	CDD:409353	6/34 (18%)
		Ig strand D	87..94	CDD:409353	0/6 (0%)
		Ig strand E	97..103	CDD:409353	2/6 (33%)
		Ig strand F	110..118	CDD:409353	4/7 (57%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/8 (13%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	136..205	CDD:404760	25/76 (33%)
		Ig strand A'	142..147	CDD:409353	1/4 (25%)
		Ig strand B	153..160	CDD:409353	3/6 (50%)
		Ig strand C	166..171	CDD:409353	3/4 (75%)
		Ig strand D	177..180	CDD:409353	1/2 (50%)
		Ig strand E	184..190	CDD:409353	1/5 (20%)
		Ig strand F	197..204	CDD:409353	3/6 (50%)
		Ig strand G	211..219	CDD:409353	0/7 (0%)
		Ig_3	222..299	CDD:404760	19/88 (22%)
		putative Ig strand A	223..229	CDD:409353	0/6 (0%)
		Ig strand B	239..243	CDD:409353	2/3 (67%)
		Ig strand C	252..256	CDD:409353	0/3 (0%)
		Ig strand E	278..282	CDD:409353	2/3 (67%)
		Ig strand F	292..297	CDD:409353	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810