DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and OPCML

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001306032.1	Gene:	OPCML / 4978	HGNCID:	8143	Length:	354	Species:	Homo sapiens

Alignment Length:	340	Identity:	81/340 - (23%)
Similarity:	124/340 - (36%)	Gaps:	61/340 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 VNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFL----SKSSLLVQNVGRRDR 412
            |..|.:|...| |....:..:.||:....|.|.|...:....:..|    ::.|:::|||...|.
Human    47 VRQGESATLRC-TIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDE 110

  Fly   413 GVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQ 477
            |.|.|.|:.......:...| :....|:::....:..|..|..::|.|.|.|.|.|...|
Human   111 GPYTCSVQTDNHPKTSRVHL-IVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTW----- 169

  Fly   478 PIMDVSLHHRFAIGQ-FVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQ-HSARLNVYGPP 540
                  .|.....|| ||  |.|  .:|.||.::.|..|.|:|.|.|.:.:.. ...::.|..||
Human   170 ------RHLSVKEGQGFV--SED--EYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPP 224

  Fly   541 YVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADG---------GQL 596
            |:..........|:..|:.|..:..|:.:.:|.|....|.|.        .||         ..|
Human   225 YISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATG--------LDGMRIENKGRMSTL 281

  Fly   597 VIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVN----------SPPVIEPFKFPKNLQEGGRA 651
            ...||.. :|.|.|||:..::.|         |.|          |..|..|......:....||
Human   282 TFFNVSE-KDYGNYTCVATNKLG---------NTNASITLYEISPSSAVAGPGAVIDGVNSASRA 336

  Fly   652 QITCAVSSGDMPIYF 666
             :.|...||.:..:|
Human   337 -LACLWLSGTLLAHF 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	20/84 (24%)
		Ig	358..431	CDD:143165	18/76 (24%)
		Ig	456..533	CDD:143165	23/78 (29%)
		IGc2	553..619	CDD:197706	18/74 (24%)
		I-set	634..724	CDD:254352	8/33 (24%)
		ig	645..712	CDD:278476	6/22 (27%)
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
OPCML	NP_001306032.1	Ig	44..132	CDD:416386	21/86 (24%)
		Ig strand A'	44..49	CDD:409353	1/1 (100%)
		Ig strand B	51..59	CDD:409353	2/8 (25%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	1/5 (20%)
		Ig strand C	64..70	CDD:409353	1/5 (20%)
		CDR2	71..83	CDD:409353	3/11 (27%)
		Ig strand C'	72..76	CDD:409353	0/3 (0%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	9/33 (27%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	1/5 (20%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	0/3 (0%)
		Ig strand G	123..132	CDD:409353	1/9 (11%)
		FR4	125..132	CDD:409353	1/7 (14%)
		Ig_3	135..206	CDD:404760	25/85 (29%)
		Ig strand A	135..138	CDD:409353	1/2 (50%)
		Ig strand A'	144..148	CDD:409353	0/3 (0%)
		Ig strand B	151..160	CDD:409353	2/8 (25%)
		Ig strand C	165..170	CDD:409353	2/15 (13%)
		Ig strand C'	171..174	CDD:409353	1/2 (50%)
		Ig strand F	198..206	CDD:409353	4/7 (57%)
		Ig	224..312	CDD:416386	23/105 (22%)
		putative Ig strand A	224..230	CDD:409353	2/5 (40%)
		Ig strand B	240..244	CDD:409353	1/3 (33%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	279..283	CDD:409353	1/3 (33%)
		Ig strand F	293..298	CDD:409353	3/4 (75%)
		Ig strand G	306..309	CDD:409353	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810