DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and NCAM2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	720	Identity:	176/720 - (24%)
Similarity:	288/720 - (40%)	Gaps:	137/720 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 CSASGSPP------PQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYK 518
            |:|.|.|.      ||...::.:|.::             |...| |.|.|.|.:...:|.|:|:
Human    67 CTAIGEPESIDWYNPQGEKIISTQRVV-------------VQKEG-VRSRLTIYNANIEDAGIYR 117

  Fly   519 CVASNSMGSVQH-SARLNVYGP-PYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTT 581
            |.|:::.|..|. :..|.:|.. .:...:.|.:...|||..|.|..:..|...:.|...::|:||
Human   118 CQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTT 182

  Fly   582 SNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRA-GEEARRDMQLNVNSPPVIE-PFK-FPK 643
            .:....|.:|: ..|.|.|:... |:|||.|..|..| ||...||:.:.||.||.|. |.| |..
Human   183 ISDNRFAMLAN-NNLQILNINKS-DEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNA 245

  Fly   644 NLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFY-----SLLVFKDISARHSG 703
            ..:.|.....:|..|....|. .||.::.       ::.|:.|::.     :.|..::|.....|
Human   246 TAERGEEMTFSCRASGSPEPA-ISWFRNG-------KLIEENEKYILKGSNTELTVRNIINSDGG 302

  Fly   704 KYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITW------- 761
            .|.|.|:|.|.:....|.|||.|.|.......:|....|. :::.|:|||.|||.|||
Human   303 PYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAVDGF 366

  Fly   762 --------------FKGQ-GKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTI 811
                          .||| |..|...|.:.:            :|.|.|.|:|.:.|| |.:|::
Human   367 TFTEGDKSLDGRIEVKGQHGSSSLHIKDVKL------------SDSGRYDCEAASRIG-GHQKSM 418

  Fly   812 RINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKT-EK 875
            .:::....:|..:.....|...:|:.:.|..|.:.|.:|.|.::...:...|    ...:|| ..
Human   419 YLDIEYAPKFISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLVLPAKN----TTNLKTYST 479

  Fly   876 GVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRP 940
            |....|.|..:..:|.|.|.|.|.|..|...|...||:.:.|.:|..::|.|:...|.|:|:.:|
Human   480 GRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKP 544

  Fly   941 -FDGNSPVLSYLVQYQAL-----KYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESA 999
             ..|..|:..|.|..:.:     |.::|||                              ::...
Human   545 DSHGGVPIHHYQVDVKEVASEIWKIVRSHG------------------------------VQTMV 579

  Fly  1000 IVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPS----NVQVQTGGESELIVTWQ 1060
            ::..|.|.||:.||:.|:|...:..|::..:.:|   .|...||    :.|..:|...:|.:|.|
Human   580 VLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQT---LPVREPSPPSIHGQPSSGKSFKLSITKQ 641

  Fly  1061 IPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRA 1125
                :.....::.|.|....:.:...::.......|..|:         |..|:....|.|.|.|
Human   642 ----DDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHII---------LEHLQWTMGYEVQITA 693

  Fly  1126 MNSFG 1130
            .|..|
Human   694 ANRLG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	20/79 (25%)
		IGc2	553..619	CDD:197706	22/66 (33%)
		I-set	634..724	CDD:254352	23/96 (24%)
		ig	645..712	CDD:278476	14/71 (20%)
		IG_like	734..815	CDD:214653	27/102 (26%)
		Ig	745..815	CDD:299845	25/91 (27%)
		I-set	820..913	CDD:254352	23/93 (25%)
		Ig	838..920	CDD:299845	22/82 (27%)
		FN3	917..1033	CDD:238020	25/121 (21%)
		FN3	1040..1142	CDD:238020	19/95 (20%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	21/83 (25%)
		I-set	47..136	CDD:254352	21/82 (26%)
		I-set	142..218	CDD:254352	22/77 (29%)
		IGc2	153..214	CDD:197706	20/62 (32%)
		Ig	233..326	CDD:299845	26/100 (26%)
		I-set	240..323	CDD:254352	20/90 (22%)
		Ig5_NCAM-2	325..422	CDD:143278	29/110 (26%)
		IG_like	333..420	CDD:214653	27/100 (27%)
		IG_like	438..515	CDD:214653	20/80 (25%)
		IGc2	439..507	CDD:197706	18/71 (25%)
		FN3	521..613	CDD:238020	25/121 (21%)
		fn3	619..703	CDD:278470	19/93 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900