DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP010093

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_553994.2	Gene:	AgaP_AGAP010093 / 4578379	VectorBaseID:	AGAP010093	Length:	263	Species:	Anopheles gambiae

Alignment Length:	310	Identity:	70/310 - (22%)
Similarity:	111/310 - (35%)	Gaps:	99/310 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 PSSLQITEK----KEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMD 736
            |.::|..:.    ||....:.|.:::.:.|    |.|.|:.|.:.:     .|::...|...|
Mosquito    13 PDAVQSAQSAAAGKEAVCMVAVTENLGSCH----TLYISSRARRYS-----DVQLICNWPLCP-- 66

  Fly   737 TAIMLG---NTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQ 798
               ::|   ||:....|.:                        :...||.::.:.::|.|.|.|.
Mosquito    67 ---LVGEDQNTVRHAAERK------------------------VAKRSLQIDNSEESDMGKYECV 104

  Fly   799 ATNEIGAGLKKTIRINV---NEPARFEQSARNISSRRNDPV---------TLDCHAKGDEPITIG 851
            |.|.||....|...:.|   ..|..|        ||..:||         ||.|.|.|....::.
Mosquito   105 AENSIGTEHTKPTPLYVKVRRVPPTF--------SRPPEPVYEVMLGANLTLTCVAVGSPMPSVK 161

  Fly   852 WTQNNGRIDLNNFRFSIAEMKTEKGVDSQLT------IGH-----SDRHDSGVYRCIAENPYGRA 905
            |                     .||||..||      :|.     :|...|..|.|||::..|..
Mosquito   162 W---------------------RKGVDQDLTPENDVPVGRNVLELTDIRVSTNYTCIAQSSLGVI 205

  Fly   906 EQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQ 955
            |....:.||..|..|:.:.|.||.:..|:|.|  .:.|...:..|::||:
Mosquito   206 EATSLVKVQSLPAAPTDVTISEVTATQVRLEW--SYKGPEDLQYYVIQYK 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	10/51 (20%)
		ig	645..712	CDD:278476	9/39 (23%)
		IG_like	734..815	CDD:214653	16/83 (19%)
		Ig	745..815	CDD:299845	12/69 (17%)
		I-set	820..913	CDD:254352	26/112 (23%)
		Ig	838..920	CDD:299845	23/92 (25%)
		FN3	917..1033	CDD:238020	12/39 (31%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP010093	XP_553994.2	Ig	<88..122	CDD:299845	10/33 (30%)
		I-set	128..213	CDD:254352	26/113 (23%)
		Ig	143..212	CDD:299845	21/89 (24%)
		fn3	219..>259	CDD:278470	11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910