DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and trol

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001027038.3 Gene:trol / 45320 FlyBaseID:FBgn0284408 Length:4479 Species:Drosophila melanogaster


Alignment Length:2318 Identity:452/2318 - (19%)
Similarity:762/2318 - (32%) Gaps:721/2318 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 LAVLATPLLATSGLRVPTFLLEPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPG- 85
            :.:.|||.:.|....:...:||.|   :.....||     .|.|...|..  ...|.:.|.... 
  Fly  2561 ILIRATPRVPTQSTSIGNVILESA---VTTRTPGA-----THASDIELCQ--CPSGYVGTSCESC 2615

  Fly    86 ----LRKISGNGTLHFPPFLAQYYRTDVHEATY---RCRA------SNEAGTVLSRNVQVHAVVR 137
                .|..||:.:| .|..::.....|:....|   ||:|      ..|..|....::.....|.
  Fly  2616 APLHYRDASGSCSL-CPCDVSNTESCDLVSGGYVECRCKARWKGDRCREIDTNDPTDIGTEDPVL 2679

  Fly   138 RQFHVHVENTEVYL---GNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASG 199
            .|..|.::..|:.:   |.|..:.|:..........:.:|:: |...||:..:|.|        |
  Fly  2680 TQIIVSIQKPEITIVPVGGSMTLSCSGRMRWSNSPVIVNWYK-ENSRLPENVEVQG--------G 2735

  Fly   200 DLYVRSVRSEDGLMKFSCLVTNTLNGERQR--SDAVMLQVKELSKNLAPRTTQKPVMEIHVERGN 262
            :||:..::..|.    ...:...:|.|...  .|.|.:.:.: ...|:|.........:..|...
  Fly  2736 NLYLYDLQVSDS----GVYICQAVNNETASVFKDTVSITITK-KDQLSPAEIVNLPSHVTFEEYV 2795

  Fly   263 DVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFG 327
            :..:.|.:.|||.|..||.||...|.    ..|.|...:|  |:..:..:.|.|::.|||.|.  
  Fly  2796 NNEIICEVLGNPAPRVTWARVDGHAD----AQSTRTYDNR--LIFDSPRKSDEGRYRCQAEND-- 2852

  Fly   328 EQRIEIRLSVNSYVSVHIL-------PQ-------VQIVN--SGGTANFNCTTTGSAIDAIDWLH 376
            :.|.|      .||.|::.       ||       .:.:|  :|.:...||..|..|....||.|
  Fly  2853 QNRDE------KYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQLNCQFTSVASLRYDWSH 2911

  Fly   377 NGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCL----------VENQRASAQAMAE 431
            ||:.|.::.|     .|:. :..::|.|::....|.|||.|:          .|:.|.:.....|
  Fly  2912 NGRSLSSSPA-----RNVE-IRGNTLEVRDASESDSGVYTCVAYDVRTRRNFTESARVNIDRREE 2970

  Fly   432 LKLGDTVPELIYTFIEQNVR--PGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFV 494
            ...|:   :.|...:|||:.  .|...|:.|.|||||.|...|          :..|.| :.:.|
  Fly  2971 QPFGN---KPIIESLEQNILIIQGEDYSITCEASGSPYPSIKW----------AKVHDF-MPENV 3021

  Fly   495 DMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGP---PYVRAI-GPIKAVA-GE 554
            .:||:|   |.|...|.::.|:|.|||.|..||...|..::: .|   |.|:.: .|::..: |.
  Fly  3022 HISGNV---LTIYGARFENRGVYSCVAENDHGSDLSSTSIDI-EPRERPSVKIVSAPLQTFSVGA 3082

  Fly   555 DIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAG 619
            ...::|...|.|...:.|.:...:..:..|    .:...|.:||.:::. .|.|.|.|..::..|
  Fly  3083 PASLYCTVEGIPDPTVEWVRVDGQPLSPRH----KIQSPGYMVIDDIQL-EDSGDYECRAKNIVG 3142

  Fly   620 EEARRDMQLNVNSPPVIE--PFKFPKNLQEGGRAQITCAVSSGDMPIYFSW------KKDDSSIP 676
             ||.....:.|..|.:::  |......|.||....:|| |.||.......|      |:|..|.|
  Fly  3143 -EATGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTC-VGSGVPNPEVEWVNEMALKRDLYSPP 3205

  Fly   677 SSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWR---------- 731
            |:..|         |.::: ::...:|.|||:..|.|.    :.|..|||..:.|          
  Fly  3206 SNTAI---------LKIYR-VTKADAGIYTCHGKNEAG----SDEAHVRVEVQERRGDIGGVDDD 3256

  Fly   732 -------YEPMD--------------TAIMLGNTISINCE-----------AEGYPIPTITWFKG 764
                   |.|..              .|..:|:.:::.|:           .:|.|:|...:   
  Fly  3257 SDRDPINYNPPQQQNPGIHQPGSNQLLATDIGDNVTLTCDMFQPLNTRWERVDGAPLPRNAY--- 3318

  Fly   765 QGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGA-GLKKT-------------IRINV 815
                       :::|...::.:...| .|.|.|   |.||. |..||             ||...
  Fly  3319 -----------TIKNRLEIVRVEQQN-LGQYRC---NGIGRDGNVKTYFVKELVLMPLPRIRFYP 3368

  Fly   816 NEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQ 880
            |.|...| :.:|:.        :.|..:...|..:.|:.:|.|...::.|.          |.|.
  Fly  3369 NIPLTVE-AGQNLD--------VHCQVENVRPEDVHWSTDNNRPLPSSVRI----------VGSV 3414

  Fly   881 LTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPD----TPSHLEIFEVGSR---------- 931
            |......:..:|.|||.|.|.||...||..:||::..|    ..|.|:....|..          
  Fly  3415 LRFVSITQAAAGEYRCSAFNQYGNRSQIARVAVKKPADFHQVPQSQLQRHREGENIQLQCTVTDQ 3479

  Fly   932 -------TVKLSW----RRPFDGNSPVLSYLV-----------QYQALKYLQSHGS--------- 965
                   .|:.:|    |||...|:...|.::           :|....|....|.         
  Fly  3480 YGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDAGRYICNSYDVDRGQQLPEVSIDL 3544

  Fly   966 --LAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTP---ATTFL-------------- 1011
              |.|....:|.....|||..|.....|        |.|..||   :..:|              
  Fly  3545 QVLRAPQYPYNRFKGGVSLKDTPCMVLY--------ICAAATPPPNSPIYLPPQLPAKSRDYSLK 3601

  Fly  1012 -------IRMQAINEIE----RSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRE 1065
                   :|.....::|    ...||: :|.:..:.||..  :||: |.|  :.|::: .:.|.:
  Fly  3602 LDDQSSNLRAGESTDVECYSSDDTYTD-VVWERSDGAPLS--NNVR-QVG--NRLVIS-NVSPSD 3659

  Fly  1066 SWN---------GEL--IGYTVNCSEEKQNINFISVV------NSSLKSTIVSG------WATTK 1107
            :.|         |:|  ..|.:...::...:....:|      |:.|:......      |:...
  Fly  3660 AGNYVCKCKTDEGDLYTTSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQY 3724

  Fly  1108 ATLRGLRKYSRYAVTIRAMNSFGSGPW---SAAIFGTTAE-----GVPEAAPQ-------NVNCT 1157
            ..|:..|......:::.::.:..:|.:   :....|.||:     .|..|.||       .::..
  Fly  3725 GQLQAGRSLMNEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQFRQEPRSYMSFP 3789

  Fly  1158 ALSSQSLKISW---LEPP-----LQFHG-----GIIQGYKILYRPIVHQIDFPAKLEIKRTSNLE 1209
            .|.:.|.|.::   ..|.     |.|:|     |......:..|....:.||..|..:.|... .
  Fly  3790 TLPNSSFKFNFELTFRPENGDGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPMLVRAEE-P 3853

  Fly  1210 TYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDA-PAAIKAAAL-TADSILI----S 1268
            ..|:..|     ::||..:...|        :.|.|:..|.| |...:...| ..:.:.|    :
  Fly  3854 LALNEWH-----TVRVSRFKRDG--------YIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPN 3905

  Fly  1269 W-LTPKNR-------NGIISHYTVYSREAGRKGQAKTHMVRVD----------ENGYPVTFESRS 1315
            | |.|.:.       .|.||..|:..|......:||......|          ..|  |..||::
  Fly  3906 WELLPADAVSQQVGFVGCISRLTLQGRTVELIREAKYKEGITDCRPCAQGPCQNKG--VCLESQT 3968

  Fly  1316 LAENQMYEF-----WVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAV 1375
               .|.|..     |.....:: ||           |:....:...|    :...|...:|||. 
  Fly  3969 ---EQAYTCICQPGWTGRDCAI-EG-----------TQCTPGVCGAG----RCENTENDMECLC- 4013

  Fly  1376 GNPTPRARWLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKP 1440
              |..|    :.||    ..:.|:.||.:|.......:..|....|..|:         .::::|
  Fly  4014 --PLNR----SGDR----CQYNEILNEHSLNFKGNSFAAYGTPKVTKVNI---------TLSVRP 4059

  Fly  1441 PSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWSITELLPENNAFTISGLKCGN 1505
            .|....::.|.:..:                                  ||..:...:. |:.|:
  Fly  4060 ASLEDSVILYTAEST----------------------------------LPSGDYLALV-LRGGH 4089

  Fly  1506 QYIIKMSAHNMVGSGVASEE---INVWTK------------------GKASQAPNANELIATNAT 1549
            ..::..:|..:....|.|.|   :|.||:                  .:.::||.::.::     
  Fly  4090 AELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKAKAPGSDRIL----- 4149

  Fly  1550 CVNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISA 1614
              :||...:..|                       .|.|..:.||:..|                
  Fly  4150 --SLKTHLYVGG-----------------------YDRSTVKVNRDVNI---------------- 4173

  Fly  1615 TNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSII 1679
                          |...||              .::.|.|...|                   :
  Fly  4174 --------------TKGFDG--------------CISRLYNFQKP-------------------V 4191

  Fly  1680 TIALTIKHRRTL--CGPIAEGYESRTLPGDYKEDHENRRNQQVYSASPVKTVD-KGNESEMYEIS 1741
            .:...||....:  ||      |:..:.||...|:|        ...|..|.| ..||.:.|.::
  Fly  4192 NLLADIKDAANIQSCG------ETNMIGGDEDSDNE--------PPVPPPTPDVHENELQPYAMA 4242

  Fly  1742 PYATFSVNGGRTGAPAKTPTRAVAA------------QTPLDYTMQFKTFGHPEGENLNATAY-P 1793
            |.|:.....|  |:.::....||.:            ...|.:...|:..|:.|   ||.:.: |
  Fly  4243 PCASDPCENG--GSCSEQEDVAVCSCPFGFSGKHCQEHLQLGFNASFRGDGYVE---LNRSHFQP 4302

  Fly  1794 LLPSSGFGHVKSKSSWHKQRYYNTEDESTLSKSMTIVA--GSQAGHSKKSNGGRSAKSSAACSGV 1856
            .|               :|.|.:.....|.:|...::.  |.:||   :...|:...::|...|.
  Fly  4303 AL---------------EQSYTSMGIVFTTNKPNGLLFWWGQEAG---EEYTGQDFIAAAVVDGY 4349

  Fly  1857 VAGS---ESDTSISPSTEF--SNMPTYRVPCKSSRSSDGRAVVDMFRPDSSTESNNDQGSPAPER 1916
            |..|   :.:.::..:::.  .|...:.|..|...::   |::::.|...|.|:.     |..::
  Fly  4350 VEYSMRLDGEEAVIRNSDIRVDNGERHIVIAKRDENT---AILEVDRMLHSGETR-----PTSKK 4406

  Fly  1917 RHNTPRHVLGMGMAMGLGGGGGGGVGGGNGPAEKRSAGQRSRKHGSAAQQPSNQTLERRKCPGSS 1981
            ....|                 |.|..|..|..:...|.| .||                   :.
  Fly  4407 SMKLP-----------------GNVFVGGAPDLEVFTGFR-YKH-------------------NL 4434

  Fly  1982 NSLDSEVDAETAASLAASIAAMAGSGAGA-----DLSGGFRPP 2019
            |.....|:.||...:..|.||:.|..|..     |..||..||
  Fly  4435 NGCIVVVEGETVGQINLSSAAVNGVNANVCPANDDPLGGTEPP 4477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 18/90 (20%)
Ig 56..125 CDD:143165 17/82 (21%)
I-set 246..337 CDD:254352 24/90 (27%)
Ig 264..334 CDD:143165 22/69 (32%)
I-set 345..433 CDD:254352 26/113 (23%)
Ig 358..431 CDD:143165 21/82 (26%)
Ig 456..533 CDD:143165 27/76 (36%)
IGc2 553..619 CDD:197706 13/65 (20%)
I-set 634..724 CDD:254352 24/97 (25%)
ig 645..712 CDD:278476 20/72 (28%)
IG_like 734..815 CDD:214653 20/119 (17%)
Ig 745..815 CDD:299845 17/94 (18%)
I-set 820..913 CDD:254352 21/92 (23%)
Ig 838..920 CDD:299845 22/85 (26%)
FN3 917..1033 CDD:238020 32/190 (17%)
FN3 1040..1142 CDD:238020 18/127 (14%)
fn3 1150..1237 CDD:278470 20/106 (19%)
FN3 1263..1345 CDD:238020 21/108 (19%)
Ig 1350..1436 CDD:299845 16/85 (19%)
IG_like 1358..1436 CDD:214653 15/77 (19%)
FN3 1441..1530 CDD:238020 11/91 (12%)
FN3 1542..1620 CDD:238020 8/77 (10%)
trolNP_001027038.3 LDLa 447..480 CDD:238060
LDLa 532..564 CDD:238060
LDLa 571..606 CDD:238060
LDLa 616..650 CDD:238060
LDLa 704..739 CDD:238060
LDLa 813..847 CDD:238060
LDLa 852..887 CDD:238060
LDLa 902..936 CDD:238060
LDLa 956..990 CDD:238060
LDLa 997..1030 CDD:238060
LDLa 1033..1067 CDD:238060
LDLa 1072..1105 CDD:238060
LDLa 1133..1165 CDD:238060
LDLa 1182..1215 CDD:238060
LDLa 1221..1251 CDD:238060
LDLa 1252..1286 CDD:238060
LDLa 1292..1326 CDD:238060
IG 1344..1421 CDD:214652
Ig 1344..1405 CDD:299845
LDLa 1439..1473 CDD:238060
LDLa 1479..1513 CDD:238060
LDLa 1522..1556 CDD:238060
IG_like 1566..1649 CDD:214653
Ig_Perlecan_D2_like 1574..1649 CDD:143220
Laminin_B 1748..1864 CDD:278481
EGF_Lam 1935..1989 CDD:238012
Laminin_B 2113..2238 CDD:278481
EGF_Lam <2250..2276 CDD:238012
EGF_Lam 2284..2333 CDD:238012
Laminin_EGF <2369..2399 CDD:278482
Laminin_B 2465..2587 CDD:278481 7/28 (25%)
I-set 2686..2772 CDD:254352 18/98 (18%)
Ig_2 2689..2771 CDD:290606 18/94 (19%)
Ig 2779..2865 CDD:299845 27/99 (27%)
IG_like 2798..2864 CDD:214653 25/79 (32%)
Ig 2882..2965 CDD:299845 23/88 (26%)
IG_like 2882..2950 CDD:214653 21/73 (29%)
Ig 2977..3061 CDD:299845 32/98 (33%)
IG_like 2984..3058 CDD:214653 30/87 (34%)
IG_like 3074..3152 CDD:214653 17/83 (20%)
Ig 3086..3153 CDD:299845 15/72 (21%)
I-set 3155..3243 CDD:254352 28/102 (27%)
IGc2 3171..3233 CDD:197706 20/72 (28%)
IG 3371..3447 CDD:214652 22/94 (23%)
IGc2 3377..3437 CDD:197706 16/77 (21%)
Ig 3456..3534 CDD:299845 12/77 (16%)
IG 3465..>3526 CDD:214652 9/60 (15%)
Ig 3603..3665 CDD:299845 14/68 (21%)
IG 3610..3683 CDD:214652 17/79 (22%)
IG 3696..3762 CDD:214652 8/65 (12%)
Ig 3704..3771 CDD:299845 8/66 (12%)
LamG 3784..3929 CDD:238058 31/158 (20%)
EGF 3952..3984 CDD:278437 7/36 (19%)
LamG 4032..4185 CDD:238058 31/270 (11%)
Laminin_G_2 4315..4444 CDD:280389 29/176 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11187
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.910

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