DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and robo2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster


Alignment Length:1923 Identity:377/1923 - (19%)
Similarity:616/1923 - (32%) Gaps:646/1923 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   378 GKPLQANNALTTGRDNIRFLSKSS-----------------------LLVQNVGRRDRGVYQCLV 419
            |.||:......|....|:...||.                       |.:..|.|..|.|:..|:
  Fly     8 GMPLRLQPQCLTNESEIQIKIKSKIKNKTASEIKRRHRNNRDFHGERLKIMPVDRSRRAVFPLLL 72

  Fly   420 ----------------ENQRASAQAMAELKLGDTVPEL-IYTFIEQNVRPGPLISLKCSASGSPP 467
                            ||.|     :.|..:..|||:. .:||             .|.|.|:|.
  Fly    73 LLAGLNGLTQVGALKGENPR-----IIEHPMDTTVPKNDPFTF-------------NCQAEGNPT 119

  Fly   468 PQFAWLLDSQPIMDVSLHHRFAI---GQFVDMSGDVISHLNISHVRPD-DGGLYKCVASNSMGSV 528
            |...|..|.:.:...:..||..:   |.|         .|.:.|.|.: |.|.|.|.|.|..|..
  Fly   120 PTIQWFKDGRELKTDTGSHRIMLPAGGLF---------FLKVIHSRRESDAGTYWCEAKNEFGVA 175

  Fly   529 Q-HSARLNVYGPPYVR---AIGP--IKAVAGEDIIVHC--PFAGYPVEQIRWEKAHQELTTSNHY 585
            : .:|.|.|   .::|   .:.|  .:...||..::.|  | .|.|..||.|.|..|.|....:.
  Fly   176 RSRNATLQV---AFLRDEFRLEPANTRVAQGEVALMECGAP-RGSPEPQISWRKNGQTLNLVGNK 236

  Fly   586 ELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPF--KFPKNLQE- 647
            .: .:.|||.|.|:..... |.|.|.|:|::..|........|.|:    :.||  :.|:|... 
  Fly   237 RI-RIVDGGNLAIQEARQS-DDGRYQCVVKNVVGTRESATAFLKVH----VRPFLIRGPQNQTAV 295

  Fly   648 -GGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASN 711
             |......|.:....:|... |::..|.....|:.....|:  ..|...|::....|:|||.|.|
  Fly   296 VGSSVVFQCRIGGDPLPDVL-WRRTASGGNMPLRRVHVLED--RSLKLDDVTLEDMGEYTCEADN 357

  Fly   712 AAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITW-FKGQGK----GSKD 771
            |...:..|..|.|...|::...|.:..:.:|:.:...|:|.|:|.||:.| .:|...    |.:|
  Fly   358 AVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRD 422

  Fly   772 FK---PLSMRNHSLL--LNLATDNDEGYYMCQATNEIGAGLKKTIRINVN-----EPARFEQSAR 826
            .:   .|:....|:|  ...|.::......|.|.|.:|:...:|: ::|:     .|...||...
  Fly   423 GRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTV-VSVDTQFELPPPIIEQGPV 486

  Fly   827 NISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNF-RFSIAEMKTEKGVDSQLTIGHSDRH- 889
            |.:......|.|.|...|.....:.|..:...||:... |.::::.       ..|||....|| 
  Fly   487 NQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDA-------GALTISDLQRHE 544

  Fly   890 DSGVYRCIAENPYGRAE-------------QIIFLAVQE---RPDTPSHLEIFEVGSRTVKLSWR 938
            |.|:|.|:|.|..|::.             .|.|....|   .|..|...::.|.|..:|.|||.
  Fly   545 DEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWT 609

  Fly   939 RPFD-GNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVA 1002
            |... |.|.::.|:::.....  ::.|.:|          :...:.:|:.:::            
  Fly   610 RSNKVGGSSLVGYVIEMFGKN--ETDGWVA----------VGTRVQNTTFTQT------------ 650

  Fly  1003 GLTPATT--FLIRMQAINEIE-RSAYTEAIVLKTQ--------EEAPTEAPSNVQVQTGGES--- 1053
            ||.|...  ||||.:..:.:. .|..:|.|.:.|:        .||.....|...|:....|   
  Fly   651 GLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASVVD 715

  Fly  1054 --ELIVTWQIPPRESWNGELI-GYTV-----------NCSEEKQNINFI--SVVNSSLKSTIVSG 1102
              .:.:||||     .||:.: |:.|           |.:....|.|.:  |...|:..|...|.
  Fly   716 STSMKLTWQI-----INGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASA 775

  Fly  1103 WATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVN-----CTALS-- 1160
            ..:||..:....|  |...|    |..|.|                 ||..:|     .|.|:  
  Fly   776 LISTKPNIAAAGK--RDGET----NQSGGG-----------------APTPLNTKYRMLTILNGG 817

  Fly  1161 -SQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIR 1224
             :.|..|:          |::|                               :||     |...
  Fly   818 GASSCTIT----------GLVQ-------------------------------YTL-----YEFF 836

  Fly  1225 VLAYTATGDGLASHPLFCQTDDDVP-DAPAAIKAAALTADSILISWLTP--KNRNGIISHYTVYS 1286
            ::.:..:.:|..|:....:|.:||| :||..::|..|.:.::.:.|..|  |:|:|::.:|.|..
  Fly   837 IVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPELKDRHGVLLNYHVIV 901

  Fly  1287 REAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEG----------EP-TSV 1340
            |...........:..|..:....|....:|.|..||...|:|..:.|.|          :| |..
  Fly   902 RGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKR 966

  Fly  1341 IAQATNTRAPARIASFGQVVRK---AVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNE 1402
            :....|.|.|........|:.:   .:..|.:|..|.                ::|.....|..:
  Fly   967 LDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLM----------------LSFGAMVFVKRK 1015

  Fly  1403 GNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGG 1467
            ..:.......::.||:|        ||       .:|.||.           |.|       :| 
  Fly  1016 HMMMKQSALNTMRGNHT--------SD-------VLKMPSL-----------SAR-------NG- 1046

  Fly  1468 APLQGYTISYHTAGESWSITELLPENNAFTISGLK---------CGNQYIIKMSAHNMVGSGVAS 1523
               .||.:...|.|..|.     |.....::...|         ||       :..:..|.|.:|
  Fly  1047 ---NGYWLDSSTGGMVWR-----PSPGGDSLEMQKDHIADYAPVCG-------APGSPAGGGTSS 1096

  Fly  1524 EEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIH--HFSIEHRPLGDIRWTVVTSD 1586
                    |.:..|                  .|..:||..||  |                   
  Fly  1097 --------GGSGGA------------------GSGASGGDDIHGGH------------------- 1116

  Fly  1587 ISNAEENRENLI--FCDFLPAKWYQLRISATNDAGKTTEHY--HFSTTNIDGITIPPPSVFPSEN 1647
              .:|.|::..:  :.: :|..:.::     :..||....|  |       |...|.|       
  Fly  1117 --GSERNQQRYVGEYSN-IPTDYAEV-----SSFGKAPSEYGRH-------GNASPAP------- 1159

  Fly  1648 DLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGYESRTLPG------ 1706
                             :||..:            |:...::....|   .|:.|.:||      
  Fly  1160 -----------------YATSSI------------LSPHQQQQQQQP---RYQQRPVPGYGLQRP 1192

  Fly  1707 ---DY-KEDHENRRNQQVYSAS---------PVKTV--DKGNESEMYEISPYATFSVNGGRTGAP 1756
               .| ::.|:.::.||.:...         |...:  .....||:|                 |
  Fly  1193 MHPHYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIY-----------------P 1240

  Fly  1757 AKT-PTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDE 1820
            ..| |:|:|       |:.|:              .||.               .|||:.:. .|
  Fly  1241 TNTGPSRSV-------YSEQY--------------YYPK---------------DKQRHIHI-TE 1268

  Fly  1821 STLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISP-STEFSNMPTYRVP--C 1882
            :.||...|..|...|..|                            || |::|:::...::|  |
  Fly  1269 NKLSNCHTYEAAPGAKQS----------------------------SPISSQFASVRRQQLPPNC 1305

  Fly  1883 KSSRSSDGRAVVDMFRPDSSTESNNDQGSPAPERRHNTPRHVLGM-GMAMGLGGGGGGGVGGGNG 1946
            ...|.|....|:           |.|||        ...:::|.: |.:|...|....|.||...
  Fly  1306 SIGRESARFKVL-----------NTDQG--------KNQQNLLDLDGSSMCYNGLADSGCGGSPS 1351

  Fly  1947 PA-------------------------------EKRSAGQRSRKHGSAAQQPSNQTLE--RRKCP 1978
            |.                               |::...|:.:......|.|:...|:  |.:..
  Fly  1352 PMAMLMSHEDEHALYHTADGDLDDMERLYVKVDEQQPPQQQQQLIPLVPQHPAEGHLQSWRNQST 1416

  Fly  1979 GSSNSLDSEVDAETA------ASLAASIAAMAGSGAGADLSGGFRPPAGFHDGRE--PGDHSDCE 2035
            .||.....|...|.:      .|:|:..:.::.||:|..     ..||| |:...  ||  |...
  Fly  1417 RSSRKNGQECIKEPSELIYAPGSVASERSLLSNSGSGTS-----SQPAG-HNVXPLLPG--SSLG 1473

  Fly  2036 REQRALDLEVQRVMESTGDAQLAKMDREELTSLLARYH 2073
            :.|.....:.|...:.....||...:..||.:...|::
  Fly  1474 QSQSKSQSQSQSQSDLQSQEQLYAREVRELLAWCERFN 1511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 17/93 (18%)
Ig 358..431 CDD:143165 16/91 (18%)
Ig 456..533 CDD:143165 21/81 (26%)
IGc2 553..619 CDD:197706 22/67 (33%)
I-set 634..724 CDD:254352 22/93 (24%)
ig 645..712 CDD:278476 14/68 (21%)
IG_like 734..815 CDD:214653 21/90 (23%)
Ig 745..815 CDD:299845 19/79 (24%)
I-set 820..913 CDD:254352 25/107 (23%)
Ig 838..920 CDD:299845 23/99 (23%)
FN3 917..1033 CDD:238020 25/119 (21%)
FN3 1040..1142 CDD:238020 26/120 (22%)
fn3 1150..1237 CDD:278470 13/94 (14%)
FN3 1263..1345 CDD:238020 20/94 (21%)
Ig 1350..1436 CDD:299845 12/88 (14%)
IG_like 1358..1436 CDD:214653 11/80 (14%)
FN3 1441..1530 CDD:238020 17/97 (18%)
FN3 1542..1620 CDD:238020 9/81 (11%)
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 32/124 (26%)
I-set 91..184 CDD:254352 30/119 (25%)
I-set 190..279 CDD:254352 25/91 (27%)
Ig2_Robo 193..279 CDD:143201 25/88 (28%)
I-set 283..370 CDD:254352 22/89 (25%)
Ig 300..370 CDD:299845 17/72 (24%)
Ig 388..>457 CDD:299845 17/68 (25%)
I-set 479..561 CDD:254352 23/88 (26%)
Ig 496..561 CDD:143165 20/71 (28%)
FN3 588..681 CDD:238020 24/116 (21%)
FN3 <817..856 CDD:238020 9/84 (11%)
fn3 864..952 CDD:278470 22/87 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45452274
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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