DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and plum

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	1516	Identity:	276/1516 - (18%)
Similarity:	486/1516 - (32%)	Gaps:	444/1516 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PPLVTWVLRDGSLATQVPGLRK----ISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLS 127
            |...:|...|  :..:....||    |..||||..|       ..:.....|.|:...:...|:|
  Fly    93 PIYCSWYRND--VVVEQVSYRKNDFFIYDNGTLRLP-------TNEKASGEYYCKIEWDESAVIS 148

  Fly   128 RNVQV-HAVVRRQF--HVHVENTEVYLGNSALIKCAIPEYVRPYVRVA----SWHRGEEILLPDL 185
            ..:.| :.|::|.|  .....|.........::.|       |::.|.    ||:.|.:.|..|.
  Fly   149 DRITVEYPVLKRLFPGQQQAANISALENKPLVLSC-------PFLSVPAARFSWYFGNDSLTNDN 206

  Fly   186 SDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRT-- 248
            |      .::..:|.|.:|.:|.|.. .|:.|:..||...:..|.....|||:.......|:.
  Fly   207 S------ALILTNGTLILRHLRLEQA-GKYKCVAQNTFASKTHRQFIWQLQVEPKDATFYPKNEA 264

  Fly   249 --TQKPVME-----------IHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVIL 300
              |:..|.|           :.|..|..|.|.|:...:..|| .||       |.| |:::.|.|
  Fly   265 GITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPI-VWY-------LQP-PNNKMVRL 320

  Fly   301 SRTLLL--IKNAD-ERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNC 362
            |...:.  |.||. .|..|::.|  ......|..::.::....: |..|| |::|..|.:....|
  Fly   321 SNNSVAYSITNASIARHEGRYSC--ITPLETQNFQVIVTTPPRI-VSRLP-VEVVYIGLSRTLTC 381

  Fly   363 TTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQ 427
            ...|....:|.|.|||  :..|::.|      |::|.:.|.|.:...::.|:|||:..|......
  Fly   382 RAEGHPEPSITWYHNG--VHLNSSYT------RYISGNELHVHSFDSKEEGIYQCVARNVAGEDS 438

  Fly   428 AMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQ 492
            |..||:....:.|:           .||.:::|.     |..|       ..::::...|.....
  Fly   439 ATGELRFNRQLEEV-----------NPLQNIRCY-----PHSF-------HSINITFDSRTLTSM 480

  Fly   493 FVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGP--PYVRAIGPIKAVAGED 555
            ||         :.|....|.....:..:..|....|..|..|.||.|  ...|.:.|...|....
  Fly   481 FV---------VYIVRNNPHSWTSFSPMKLNQTSYVVISTDLPVYEPFALITRVLFPTTEVRTGT 536

  Fly   556 II-------------VHCPFAGYPVEQI--------RWEKAHQELTTSNHYELASVADGGQLVIK 599
            ::             |.|...|..:..|        :|.:.  :|....::.|       |..|.
  Fly   537 LVPQQMILSSLRSTPVTCCTQGLMLRPIAVGNDTFVKWSQG--QLENKKYFIL-------QFSIN 592

  Fly   600 NVEP-------GRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAV 657
            :..|       |..||..|.:      ||....::.::..   |:|      |.:...|.:...|
  Fly   593 HTHPHPAQLLNGSLQGTLTSV------EEKADQVRHHLTE---IQP------LNQSAAATVLRNV 642

  Fly   658 SSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAEL 722
                       :.:|:.:..:|::   :::.:||:|...::.....::|              .:
  Fly   643 -----------EHEDNVVDDTLEL---EDDIFSLVVDASVTGILLQRFT--------------RI 679

  Fly   723 QVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLA 787
            ::||                  :.|..|.|         |.||     ||:.:..:   ::.|
  Fly   680 KMRV------------------LIITTENE---------FLGQ-----DFRYVQWK---IIEN-- 707

  Fly   788 TDNDEGYYMCQATNEIGAGLKKTIRINVNEPARF-EQSARNISSR----RNDPVTLDCHAKGDEP 847
                       .|:|           ..|.|.|. .:.:|.::.:    .|:...|:||.:....
  Fly   708 -----------GTSE-----------QSNMPFRLVTRESRALAFKFLDSLNETCVLECHTEIQAQ 750

  Fly   848 ITIGWTQNNGRIDLN--NFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIF 910
            :::. :|:....|.|  |....:..:|.:            .|::...|.|.....||..::
  Fly   751 MSLP-SQDPKCQDRNIANSLLLVTGLKPD------------TRYNLHFYNCKTRIFYGDIDE--- 799

  Fly   911 LAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNG 975
            ...|:.|.|.|:.::  :....:||.|..|.:.|..|..|.:::
  Fly   800 KTEQDPPGTISNSKL--IKQNGLKLMWEPPINPNGRVHHYDIRW--------------------- 841

  Fly   976 HVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTE 1040
                          |.|:...|:                 .:.|..:.:|....|   .|.|...
  Fly   842 --------------SLDNVTHEA-----------------IVKECTKCSYKFPNV---SETAKIH 872

  Fly  1041 APSNVQVQTGGESELIV-------TWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKST 1098
            ....|...||..:.:..       ||.....||.:.|:               :..:...||.|.
  Fly   873 VAVRVMGDTGAGAPMYFDMINNNHTWLKEESESSHSEV---------------YSGIAIGSLLSI 922

  Fly  1099 ---------IVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFG--TTAEGVPEAAPQ 1152
                     |:......||..:|    ..:..|...:|           ||  ::|.|:|..:..
  Fly   923 ACVFLFGLFIIFQQRNFKARAQG----PTHLTTPTDIN-----------FGNLSSASGMPGDSAG 972

  Fly  1153 NVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYR------PIVHQIDFPAKLEIKRTSNLETY 1211
            .::...|.....::..|.|..::|..::..:.:.|:      .:||..:....:::.|.|:.:.
  Fly   973 GLSGGTLQQDCHEMQTLIPRSRYHIELLPEHSLEYQTSTAAVAVVHLANGNGSVQVARRSDQDG- 1036

  Fly  1212 LHTLHKASNYSIRVLAYTATGD-GLAS-HPL----FCQTDDDVPDAPAAIKAAALTADSILISWL 1270
                             .|.|| |:|. |.|    .|......|:......|....|.:..|.:.
  Fly  1037 -----------------AAQGDLGIAGVHNLSQLPLCGVGGTSPERKTVQDAMLQEAKAFYIPYR 1084

  Fly  1271 -TPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGE 1334
             ||.|...:.|     |::......::..:: |..|..|:......|..       |....|.|.
  Fly  1085 HTPPNAVALSS-----SKQCAVPSGSELEVI-VPPNSLPLVTTMPGLGV-------VGGGGSGGG 1136

  Fly  1335 GEPTSVIAQATNTRAPARIASFGQ---------VVRKAVGTGLVL----ECLAVGNPTPRARW-- 1384
            |...|.....:.:.:.|..:|.|.         |.......|:.|    |..|...||....:
  Fly  1137 GVGGSSRRSGSLSSSSASSSSNGSSKKQFHTNFVRHSNSNDGIYLLAEEEAAATLTPTSEREYAA 1201

  Fly  1385 --------LTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPP 1441
                    |..|...:....|..||..|...:..:.|.:........|   .:.|.:...|.|.|
  Fly  1202 VCLTNGFKLPADVAKSGGGTYNTTNNNNSSTNTSQKSATAKERQPRGN---GNPISFSHNACKVP 1263

  Fly  1442 SAPQIIVQYASADSIRVSWDA 1462
            :.....|....:.:::.||.|
  Fly  1264 ANGPASVNVNHSSAVKQSWPA 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	16/70 (23%)
		Ig	56..125	CDD:143165	13/61 (21%)
		I-set	246..337	CDD:254352	26/108 (24%)
		Ig	264..334	CDD:143165	20/72 (28%)
		I-set	345..433	CDD:254352	25/87 (29%)
		Ig	358..431	CDD:143165	19/72 (26%)
		Ig	456..533	CDD:143165	11/76 (14%)
		IGc2	553..619	CDD:197706	14/93 (15%)
		I-set	634..724	CDD:254352	11/89 (12%)
		ig	645..712	CDD:278476	9/66 (14%)
		IG_like	734..815	CDD:214653	11/80 (14%)
		Ig	745..815	CDD:299845	11/69 (16%)
		I-set	820..913	CDD:254352	16/99 (16%)
		Ig	838..920	CDD:299845	15/83 (18%)
		FN3	917..1033	CDD:238020	16/115 (14%)
		FN3	1040..1142	CDD:238020	19/119 (16%)
		fn3	1150..1237	CDD:278470	13/93 (14%)
		FN3	1263..1345	CDD:238020	15/82 (18%)
		Ig	1350..1436	CDD:299845	19/108 (18%)
		IG_like	1358..1436	CDD:214653	16/100 (16%)
		FN3	1441..1530	CDD:238020	5/22 (23%)
		FN3	1542..1620	CDD:238020
plum	NP_001163744.1	IG_like	170..241	CDD:214653	19/84 (23%)
		IGc2	175..235	CDD:197706	16/73 (22%)
		IG_like	284..356	CDD:214653	22/82 (27%)
		I-set	360..443	CDD:254352	25/92 (27%)
		IGc2	378..435	CDD:197706	18/64 (28%)
		FN3	804..886	CDD:238020	21/138 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840