DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and side-IV

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	1124	Identity:	255/1124 - (22%)
Similarity:	380/1124 - (33%)	Gaps:	351/1124 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 ELSKNL---APRTTQKPVMEIHVERGNDVHLPCNI----QGNPFPIFTWYRVSDSAALYPIPSSQ 296
            ||.:||   .|.||.:.|:      |....|||:|    :.:...:..|:|..|...:|
  Fly    67 ELMQNLDRPVPLTTVQGVL------GRQAMLPCDISPQERDDAVYMVLWFREGDGEPIY------ 119

  Fly   297 RVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFN 361
                        |.|.|         ..|||:.|  :..|..::              |..|:|:
  Fly   120 ------------NFDVR---------GRQFGQAR--LWSSPTAF--------------GTRAHFS 147

  Fly   362 CTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASA 426
            .||              .|.|                   |.:.|:...|.|||:|.|:.:.:..
  Fly   148 STT--------------HPAQ-------------------LKIDNIRIEDEGVYRCRVDFRNSPT 179

  Fly   427 QAMAELKLGDTV---PE--LIY------------TFIEQNVRPGPLISLKCSASGS-PPPQFAWL 473
            :   .||:..||   |:  :||            :|.|.|.     |.|.|..||. |.|...|.
  Fly   180 R---NLKINLTVIVPPDRPVIYGQNRHEKAGNVESFSEGND-----IVLSCEVSGGRPRPNVTWY 236

  Fly   474 LDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHV-RPDDGGLYKCVASNSMGSVQHSARLNVY 537
            ||:..| |.|...|        ..|..|:||:..:| |........|||||:          |:
  Fly   237 LDNTAI-DESFEQR--------PDGKTINHLSYPNVGRQHLNSRLMCVASNT----------NL- 281

  Fly   538 GPPYVRAIGPIKAVAGEDIIVH-----------------CPFAG-YPVEQIRWEKAHQEL--TTS 582
            .||..|.:  |..|..:.|.||                 |..:| .|...|.|.|..::|  .|.
  Fly   282 TPPNNRVV--ILDVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTK 344

  Fly   583 NHYELASVADGGQLVIKNVEPGR-DQGIY-TCIVRSR--AGEEARRDMQLNVNSPPV----IEPF 639
            |..|    .|...|.|....||| |.|.| ||...::  .|.......:|.|:..|.    |...
  Fly   345 NFNE----PDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAIEDKWRLIVHYQPTTTLKIGSS 405

  Fly   640 KFPKNLQEGGRAQITCAVSSGDMPIYFSW----KKDDSSIPSSLQITEKKEEFYSLLVFKDISAR 700
            ..|.:::||..|...|.|.:...|...||    |:...:|.:.:.::::.      ||.:.:|..
  Fly   406 LNPDDIKEGDDAYFECIVLANPKPYKMSWFHNGKELQHNISAGVILSDQS------LVLQSVSRA 464

  Fly   701 HSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPM---DTAIMLG----NTISINCEAEGY-PIP 757
            .:|.|||.|.|:..|.....     |..|.||.|:   |...:||    .|:.:.||.:.. |..
  Fly   465 SAGDYTCLAVNSEGKGPSNP-----VTLRIRYAPICATDHEELLGALKHETLPLKCEVDSSPPAD 524

  Fly   758 TITW-FKGQGKGSKDFKPLSMRNHS-------LLLNLATDNDEGYYMCQATNEIGAGLKKTIRIN 814
            :..| |...|:.::    |..|.||       |....:||.|.|...|.|.|.||......:...
  Fly   525 SFQWTFNSSGEQTE----LPARLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQI 585

  Fly   815 VNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDS 879
            |.....|.....:::::..|.:.:||....|..:..|            |...:.|:.|.: :..
  Fly   586 VAAGRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQG------------FMLELVELNTLR-LAR 637

  Fly   880 QLTIGHS------DRHD-SGVYRCI--AENPYGRAEQII-----FLAVQERPDTPSHLE------ 924
            .:|:.|:      |..| :..||.:  |.|..||:|..|     |..|.:.....:.|.
  Fly   638 NITVSHTPVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIIDDINFKGVAKFTGASTGLSMPLSPF 702

  Fly   925 -------------IFEVGSRTV--KLSWRRPFDGNSPVLSYL----------------VQYQALK 958
                         ||.:....:  ::|.||. |.|..|..:.                ||.....
  Fly   703 LAGLTLFCGLLFAIFCIMLAAIYRRISNRRS-DSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSG 766

  Fly   959 YLQSHGSL------------AAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFL 1011
            ..|.|.||            ..|.||..|..:.|.|         |..::.|:.: ||.......
  Fly   767 NHQPHHSLLPLNCDGRNAVDCGALGDVGGGGVGVGL---------DGGIKGSSPI-GLVAMPGDT 821

  Fly  1012 IRMQAINEIERSA------YTEAIVLKTQ-EEAPTE---------APSNVQVQTG--GESELIVT 1058
            :|..|.|.....|      .|:..|:..| |:.|.:         :|||..:|..  .|:||
  Fly   822 LRSNARNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPGFASPSNRLMQRDYLRETEL--- 883

  Fly  1059 WQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTI 1123
                   :..|..:|  :..:|...:|..:|          .||......|.|..::.| ||
  Fly   884 -------TKGGSDVG--MGAAEGLSSIGLMS----------SSGNEVLHYTFRPSKQIS-YA--- 925

  Fly  1124 RAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYR 1188
             .:|..|....|..: |:....|..:.|  .:...|:.|.:::|.|.|........:..|:....
  Fly   926 -TLNKKGITTCSPPL-GSLNYSVSTSTP--TSSYHLTPQPMEVSLLSPNNPSVTSSLSEYRFRTG 986

  Fly  1189 PIVHQIDFPAKLEIKRTSN 1207
            |           ||..|||
  Fly   987 P-----------EIVTTSN 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	20/94 (21%)
		Ig	264..334	CDD:143165	15/73 (21%)
		I-set	345..433	CDD:254352	15/87 (17%)
		Ig	358..431	CDD:143165	14/72 (19%)
		Ig	456..533	CDD:143165	25/78 (32%)
		IGc2	553..619	CDD:197706	24/89 (27%)
		I-set	634..724	CDD:254352	23/97 (24%)
		ig	645..712	CDD:278476	18/70 (26%)
		IG_like	734..815	CDD:214653	25/96 (26%)
		Ig	745..815	CDD:299845	20/78 (26%)
		I-set	820..913	CDD:254352	22/106 (21%)
		Ig	838..920	CDD:299845	21/95 (22%)
		FN3	917..1033	CDD:238020	31/170 (18%)
		FN3	1040..1142	CDD:238020	23/112 (21%)
		fn3	1150..1237	CDD:278470	13/58 (22%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	37/193 (19%)
		IG_like	80..188	CDD:214653	36/192 (19%)
		Ig	210..281	CDD:299845	28/94 (30%)
		Ig	319..392	CDD:299845	23/76 (30%)
		IG_like	319..383	CDD:214653	22/67 (33%)
		IG_like	412..489	CDD:214653	21/87 (24%)
		IGc2	413..478	CDD:197706	19/70 (27%)
		Ig_3	509..572	CDD:290638	18/66 (27%)
		fn3	593..675	CDD:278470	19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910