DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and dpr17

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001287297.1	Gene:	dpr17 / 41470	FlyBaseID:	FBgn0051361	Length:	664	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	122/606 - (20%)
Similarity:	199/606 - (32%)	Gaps:	170/606 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TPLLATSGLRVPTFLLEPAPRLLFGNDTGAQVTCT----AHGSPPPL-VTWVLR--DGSLATQVP 84
            :||  .|.||: :|:|...|.|.||...   |||:    ...:|.|: :||..:  :|.|.|
  Fly    91 SPL--ASWLRI-SFVLLVLPALGFGIQV---VTCSNPELGASAPDPVDLTWGGKNTEGQLTT--- 146

  Fly    85 GLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEV 149
                 :...||...|...|   .|:.........:.:..|..|..|             |:..|.
  Fly   147 -----ATRSTLPDSPMTTQ---NDLITTASNLATAKKPATAASEAV-------------VDTAET 190

  Fly   150 YLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDL------YVRSVRS 208
                        .|...|....:||...........:|.||..:..:.|..:      .||...:
  Fly   191 ------------AETAPPTEATSSWSSTAVARGMSSADGAGEAIATSQSAQIGLTTQATVRQTEA 243

  Fly   209 ED-GLMKFSCLVTNTLNGERQRSDAVMLQ--VKELSKNLAPRTTQ----KPVMEIHVERG---ND 263
            :. .....:...|:........|.|...:  .:.|...:.|.:|:    ..:..:..:||   |.
  Fly   244 QTASTATQAAAATSAATSAAIASAAAATETAAEMLISTIYPASTETDLHNSIERVEGQRGKMANA 308

  Fly   264 VH--LPCNIQGN--------PFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKW 318
            .|  :|.::...        |||:|         |...:|:.:..           ||..:|.|.
  Fly   309 FHPGVPDSLTKGFSIPTFLPPFPVF---------AAADLPAYRAA-----------ADAAEAAKL 353

  Fly   319 ICQASNQFG--------------EQRIEIRLSVNSYVSVH---------------ILPQVQI-VN 353
            ..:|:.|..              |||.::....:||::.|               .:|.:.| ..
  Fly   354 AAEAAAQAAAAKTSSEAVTMSPEEQRRQMFNEQHSYLAAHRDGGDGAGSAVRRNLTMPVLNITAQ 418

  Fly   354 SGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKS--------------SLLV 404
            .|..|...|.....:...:.|:.    ::.|:.::.  |...|::..              ||.:
  Fly   419 MGNHAYMPCQIHRLSDKPVSWVR----MRDNHIISV--DETTFIADERFQSIYQEDHDYTWSLQI 477

  Fly   405 QNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQN--VRPGPLISLKCSASGS-- 465
            :.|...|.|.|:|.:..: ....|...|::.....|||.   :|:  |:.|..::|.|...|:
  Fly   478 KYVEPSDAGWYECQMATE-PKLSAKVHLQIVKPKTELIG---DQSRFVKAGSKVALHCIVRGTLD 538

  Fly   466 PPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMS-------GD---VISHLNISHVRPDDGGLYKCV 520
            ||....|....:.|.|....    .|.:..:.       ||   .|..|.|..||.:|.|.|.|.
  Fly   539 PPKYIIWFRGQKKISDSDER----TGWYTQLDRNIFGTVGDNQNTIGSLIIPLVRKEDSGNYTCQ 599

  Fly   521 ASNSMGSVQHSARLNVYGPPY 541
            .||   ||..|..|:|....|
  Fly   600 PSN---SVSVSVDLHVLSGEY 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	18/83 (22%)
		Ig	56..125	CDD:143165	15/75 (20%)
		I-set	246..337	CDD:254352	22/121 (18%)
		Ig	264..334	CDD:143165	17/93 (18%)
		I-set	345..433	CDD:254352	17/102 (17%)
		Ig	358..431	CDD:143165	14/86 (16%)
		Ig	456..533	CDD:143165	25/88 (28%)
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
dpr17	NP_001287297.1	IG_like	414..491	CDD:214653	14/82 (17%)
		Ig	415..507	CDD:299845	17/98 (17%)
		IG_like	521..612	CDD:214653	28/97 (29%)
		IGc2	524..605	CDD:197706	24/87 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810