DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and dpr11

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001262320.1	Gene:	dpr11 / 40800	FlyBaseID:	FBgn0053202	Length:	360	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	70/312 - (22%)
Similarity:	118/312 - (37%)	Gaps:	77/312 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 LTTSNHYELASVADGGQLVIKNVEPGRDQG--------IYTCIVRSRAGEEARRD-----MQLNV 630
            ||.::|.:.::.|.||:  :.....|..:|        ..|.|....:|:.:...     .|::.
  Fly    38 LTIASHTQTSAEAAGGR--VSGPGAGTSEGAGTSSASAASTAISSDESGDPSSATAFSSLAQVSS 100

  Fly   631 NSPP---------VIEPF---KFPKNL--QEGGRAQITCAVSS-GDMPIYFSWKKDDS--SIPSS 678
            ..|.         ::||:   ....|:  |.|..|.:.|.|.. |:..:.:...:|..  ::..:
  Fly   101 LLPEASALSATSGLVEPYLDGYATSNVTTQIGTHAYLPCRVKQLGNKSVSWIRLRDGHILTVDRA 165

  Fly   679 LQITE------KKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRY--EPM 735
            :.|.:      |:.:.|..|..|.:.||.:|.|.|..| ...||:...:||| |.||...  ||
  Fly   166 VFIADQRFLAIKQPDKYWTLQIKYVQARDAGSYECQVS-TEPKVSARVQLQV-VVPRTEILGEP- 227

  Fly   736 DTAIMLGNTISINCEAEG--YPIPTITWFKGQGKGSKDFKPLSMRNH------------------ 780
            |..:..|:.:.:.|...|  .|...|.|:.|..:.:.|     .|.|
  Fly   228 DRYVKAGSNVVLRCIVRGALEPPTFIMWYHGAEQLAAD-----SRRHRTQLDPNLPEASGEGQST 287

  Fly   781 --SLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISS 830
              ||::..|...|.|.|.|..:|...|    |:.:|:   ...|.||..::|
  Fly   288 IGSLIIESAKKRDTGNYTCSPSNSPSA----TVTLNI---INGESSASAVTS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706	10/47 (21%)
		I-set	634..724	CDD:254352	24/112 (21%)
		ig	645..712	CDD:278476	18/77 (23%)
		IG_like	734..815	CDD:214653	22/102 (22%)
		Ig	745..815	CDD:299845	19/91 (21%)
		I-set	820..913	CDD:254352	4/11 (36%)
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	22/91 (24%)
		Ig	127..217	CDD:299845	23/91 (25%)
		IG_like	227..320	CDD:214653	22/102 (22%)
		IGc2	234..311	CDD:197706	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810