DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and dpr13

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	76/347 - (21%)
Similarity:	120/347 - (34%)	Gaps:	97/347 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 YVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHL 266
            |.:|..|..|....|...||.::|:.|.:               |...|:.|::.|..
  Fly    89 YAQSAASAGGSSITSFDSTNVIDGQSQPT---------------PTHLQEAVLQTHSH------- 131

  Fly   267 PCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRI 331
             ..||           ..|:|..||||..:...:...|                :|:|.. |..:
  Fly   132 -SRIQ-----------AKDTAGPYPIPVHRPEPVENHL----------------EANNGI-EGGM 167

  Fly   332 EIRLSVNSYV----SVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRD 392
            |.......|.    |..:..|:     |.||:..||........:.|:...........|||...
  Fly   168 ESLFGTPMYFGTENSTVVTTQI-----GATAHVPCTVHHIGEGVVSWIRKKDYHLLTVGLTTYSS 227

  Fly   393 NIRF----LSKS---SLLVQNVGRRDRGVYQCLVENQRASA--------QAMAELKLGDTVPELI 442
            :.||    |..|   :|.::.|..||.|||:|.|.....::        :|.||:    |.|.:.
  Fly   228 DERFSATHLKHSEDWTLQIKFVQLRDAGVYECQVSTHPPTSIFLHLSVVEARAEI----TGPPIR 288

  Fly   443 YTFIEQNVRPGPLISLKCSA--SGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGD---VIS 502
            |      :.||..:.|:|..  :........|..|::.|       .:.|.:.:::|.:   ..|
  Fly   289 Y------LTPGSTLRLQCRVVQNTEASEYIFWYHDNRMI-------NYDIDRGINVSTEPDFQSS 340

  Fly   503 HLNISHVRPDDGGLYKCVASNS 524
            .|.|...|.:..|.:.|||||:
  Fly   341 ELTIQRTRREHSGNFTCVASNT 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	17/90 (19%)
		Ig	264..334	CDD:143165	13/69 (19%)
		I-set	345..433	CDD:254352	26/102 (25%)
		Ig	358..431	CDD:143165	21/87 (24%)
		Ig	456..533	CDD:143165	17/74 (23%)
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	24/100 (24%)
		IG_like	182..262	CDD:214653	23/84 (27%)
		IG_like	285..362	CDD:214653	20/89 (22%)
		IGc2	292..361	CDD:197706	17/75 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810