DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and CEACAM16

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_016882284.1	Gene:	CEACAM16 / 388551	HGNCID:	31948	Length:	473	Species:	Homo sapiens

Alignment Length:	423	Identity:	95/423 - (22%)
Similarity:	146/423 - (34%)	Gaps:	91/423 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 AVMLQV-KELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWY-----RVSDSAALY 290
            |..|.| .|:|..|.|....:         |::|.|..:........::||     .||...|.|
Human    13 ATFLNVGAEISITLEPAQPSE---------GDNVTLVVHGLSGELLAYSWYAGPTLSVSYLVASY 68

  Fly   291 ----------PIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVN-SYVSVH 344
                      |..:.:..:.....|.|:....|.:|.:|.|..|:      :::..|. .:|.||
Human    69 IVSTGDETPGPAHTGREAVRPDGSLDIQGILPRHSGTYILQTFNR------QLQTEVGYGHVQVH 127

  Fly   345 -ILPQ-------VQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSS 401
             ||.|       ..:|....|....|::.....: :.|..||..|.....|....|. |.|::
Human   128 EILAQPTVLANSTALVERRDTLRLMCSSPSPTAE-VRWFFNGGALPVALRLGLSPDG-RVLAR-- 188

  Fly   402 LLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTV---PELIYTFIEQNVRPGPLI------- 456
               ..:.|.:.|.|||.|.|. .|......:.|  ||   ||.:....:...|.|..|
Human   189 ---HGIRREEAGAYQCEVWNP-VSVSRSEPINL--TVYFGPERVAILQDSTTRTGCTIKVDFNTS 247

  Fly   457 -SLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCV 520
             :|.|.:...|.|::.|..:.|.:.:         ||         .|||||.:.....|.|.|:
Human   248 LTLWCVSRSCPEPEYVWTFNGQALKN---------GQ---------DHLNISSMTAAQEGTYTCI 294

  Fly   521 ASNS----MGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQI--RWEKAHQEL 579
            |.|:    .||.....:|:......:....|.|...|:|:.:  ...|||.:.:  .|.:.
Human   295 AKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDVTL--TVQGYPKDLLVYAWYRG---- 353

  Fly   580 TTSNHYELASVADGGQLVIKNVEPGRDQGIYTC 612
            ..|....|.|....|..:......||:.|...|
Human   354 PASEPNRLLSQLPSGTWIAGPAHTGREVGFPNC 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	18/105 (17%)
		Ig	264..334	CDD:143165	16/84 (19%)
		I-set	345..433	CDD:254352	22/94 (23%)
		Ig	358..431	CDD:143165	17/72 (24%)
		Ig	456..533	CDD:143165	21/88 (24%)
		IGc2	553..619	CDD:197706	14/62 (23%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CEACAM16	XP_016882284.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000