DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Dscam2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster

Alignment Length:	2135	Identity:	689/2135 - (32%)
Similarity:	1068/2135 - (50%)	Gaps:	234/2135 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LRVPTFLLEPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPP 99
            ||.|.|::||..|:.|.|.:|..:.|:|.|||.|.|.||..|||..|::.|:|::..||||...|
  Fly    28 LRGPGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRNGTLVLMP 92

  Fly   100 FLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEY 164
            |.|..|..|||...|||.|||..|.::||:|||.|||.:.:.|.||......|.:|:::|.:|.:
  Fly    93 FAAAAYHQDVHNTIYRCIASNSVGRIVSRDVQVRAVVAQAYKVDVEVLSAARGCTAILRCVVPTF 157

  Fly   165 VRPYVRVASW-HRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQ 228
            |:..|||.|| |.....:.|.|.. .|::.:| .:|:|.:.:::..|....|.|...:.|..:..
  Fly   158 VKELVRVVSWVHEPAIYIYPSLQG-DGKFHLL-PTGELLIHNLQESDESQSFRCRSMHRLTRQVV 220

  Fly   229 RSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIP 293
            .|....|::......::|...:. ...:.|.:.....|.|..||.|.|.::|: ..:.|...|:.
  Fly   221 VSSPTRLRINSHRGIISPSVVEH-TAHVQVSQDEGAVLLCVAQGCPSPEYSWF-THNGAGPLPVL 283

  Fly   294 SSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTA 358
            |..||.|...:|.|:.....|:|.:.|.|.|..||...|:||:|.:.:.|.|.|.|..|:.||||
  Fly   284 SGPRVRLLGPILAIEAVTGEDSGVYKCTAGNVGGEASAELRLTVATPIQVEISPNVLSVHMGGTA 348

  Fly   359 NFNC--TTTGSAI--DAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLV 419
            .|.|  |:.||.:  ..|.|..:|:.|.::..:           :.:|:|..|.|.:||:|||:|
  Fly   349 EFRCLVTSNGSPVGMQNILWYKDGRQLPSSGRV-----------EDTLVVPRVSRENRGMYQCVV 402

  Fly   420 ENQRASA-QAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVS 483
            ....... ||.|||:|||..|.|:|:||||.::|||.:||||||:|:|.||.:|.||..|:..
  Fly   403 RRPEGDTFQATAELQLGDAPPVLLYSFIEQTLQPGPAVSLKCSAAGNPTPQISWTLDGFPLPS-- 465

  Fly   484 LHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPI 548
             :.||.|||::.:.||||||:|||||..:|||.|.|:|.|..|.|||:||||:||.||:|.|..:
  Fly   466 -NGRFMIGQYITVHGDVISHVNISHVMVEDGGEYACIAENRAGRVQHAARLNIYGLPYIRLIPKV 529

  Fly   549 KAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCI 613
            .||:||.:.:.||.||||:|:|.||:..:||.......   |...|.|.|..|:...|.|:|||.
  Fly   530 TAVSGETLNLKCPVAGYPIEEIHWERGGRELPDDIRQR---VQPDGSLTISPVQKNSDSGVYTCW 591

  Fly   614 VRSRAGEEARRDMQLNVNSPPVIEPFKFP-KNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSI-P 676
            .|::.|..|||..::.|..||.:.||:.. ..|..|.||.:||:|..||:|:..:|:||...| |
  Fly   592 ARNKQGHSARRSGEVTVIVPPKLSPFQTNILQLNMGDRASLTCSVVKGDLPLTINWRKDGRPIDP 656

  Fly   677 SSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIML 741
            :.....::.:::.|:||.:::.:.|:|.|:|...|:||:|..:..|.|.|.|||..||:|..:..
  Fly   657 TQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPVDANVER 721

  Fly   742 GNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMR-------NHSLLLNLATDNDEGYYMCQA 799
            ...|.::|:|:|.|.|:|.|.|..|..|.:::.:..|       |.||||....::.||:|:|||
  Fly   722 NRHIMLHCQAQGVPTPSIVWKKATGSKSGEYEEVRERPFTKLLGNGSLLLQHVKEDREGFYLCQA 786

  Fly   800 TNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLN-- 862
            .|.||.|:.|.|::.||....|..::|::..::.|...|.|...||:||.|.| ..:|:..||
  Fly   787 NNGIGTGIGKVIQLKVNSSPYFSSTSRSVMVKKGDTALLQCAVSGDKPINIVW-MRSGKNTLNPS 850

  Fly   863 -NFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIF 926
             |::.|:.:..|..||.::|.|...|..|||.|.|.|.|.||..:|::.|.|||.|..||.||..
  Fly   851 TNYKISVKQEATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLVQLQVQEPPLPPSVLEAA 915

  Fly   927 EVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSY 991
            .:.||:|.:.|:....|...|..|:|:::     ::..||.               |:..:.:..
  Fly   916 MISSRSVNIKWQPKTLGTGDVTKYIVEFR-----EADHSLP---------------PALFVDQWQ 960

  Fly   992 DSDLRE----SAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGE 1052
            ..::::    :|::..|.|||.:..|:.|.....|||.::.::::|:.:.|...|.::..:....
  Fly   961 QIEVKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRPAGPPLSLSARPLSS 1025

  Fly  1053 SELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSG---WATTKATLRGLR 1114
            :||:::|..|..|..:|::.||.|       .....|..|::...|.|||   ....:..|.||.
  Fly  1026 TELLISWVAPLPELRHGDIQGYNV-------GYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLA 1083

  Fly  1115 KYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGI 1179
            |::||.|.::|.|..|.||.|......|.|.||...|::|.|.|||||||::||..||:....|:
  Fly  1084 KFARYTVVVQAFNQVGPGPLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGL 1148

  Fly  1180 IQGYKILYRPIVHQIDFPAK--LEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFC 1242
            :||||:::.||:..|. |:|  :|.::|:.|...|..|.|.:||||:|||:|..|||:.|.||||
  Fly  1149 LQGYKLIFEPIIDDIQ-PSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFC 1212

  Fly  1243 QTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREA-GRKGQAKTHMVRVDENG 1306
            .:::|||:|||.||..:.::.|:.||||.|...||:|:.|::|:|.. ||:...........:..
  Fly  1213 HSEEDVPEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQA 1277

  Fly  1307 YPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLE 1371
            |   :|::.|..:..|:|||:|||.||||:.:.|.:|.|..|.||||.|||..|.:...:.:.|.
  Fly  1278 Y---YEAKGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLP 1339

  Fly  1372 CLAVGNPTPRARWLTRDRPVTFSPFY--EVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQ 1434
            |.|||.  |:..|...|..:.....:  ::.:.|:|.|..::.:..|||:|..:|..|:|.:.:.
  Fly  1340 CTAVGK--PKREWFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHT 1402

  Fly  1435 VIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWSITELLPENNAFTIS 1499
            :|...||:||.:.|..|::.||.:.|.....|.||:.|||:.|..|..:....:|....::..:.
  Fly  1403 LIVQVPPTAPVLYVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELK 1467

  Fly  1500 GLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCS 1564
            ||.||:.|.|.:||.|.||:...|..::|.|:|::...|.:..|:|.|:|.:.::|.||.:.||.
  Fly  1468 GLMCGSTYQIHLSAQNKVGTSPTSTILHVRTQGQSPGHPASTALLAPNSTSLLVRLHSWPDNGCP 1532

  Fly  1565 IHHFSIEHRPL---GDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYH 1626
            :.:|.:::|.:   .|..|.:|    |||.:.:..::..:..|:..||||:.|.|.||.:...::
  Fly  1533 LLYFVLQYRAVTDDPDAEWVLV----SNALKPQRRIVINNLQPSTLYQLRMEAHNVAGISQAEFN 1593

  Fly  1627 FSTTNIDGITIPPPSVF----PSENDLMNNLINSTNPT----SGDWFATLIVVVIITVSIITIAL 1683
            |.|...|| ..|||.:.    ..:..::...||...||    || .|.|:|::::
  Fly  1594 FVTLTKDG-DPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSG-MFCTIIMIIV---------- 1646

  Fly  1684 TIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQV-----YSASPVKTVDKGNE-----SEMY 1738
            ..:|......|:||..:.:      ||..|||.|.:.     |.|:..|...:.|:     ||
  Fly  1647 CYRHMLKNAPPLAEQSQIQ------KESLENRANSEAAQRERYYATIHKVSMQNNDKIPETSE-- 1703

  Fly  1739 EISPYATFSVN--GGRT-----GAPAKT-------PTRAVA--------AQTPLDYTMQFKTFGH 1781
            :|||||||.::  ||..     |.||.|       ..||:|        |.:........||  .
  Fly  1704 DISPYATFQLSEAGGNMSQPHHGGPANTLLHSFMYHERALAEGCSSPPPAASKNRRRHSRKT--E 1766

  Fly  1782 PEGENLNATAYPLLPS------SGFGHVKSKSSWHKQRYYNTEDESTLS--KSMTIVAGSQAGH- 1837
            ||.|...:....|..|      ...|.:|....:|..:...:.|.|.:|  ||:.....|:..|
  Fly  1767 PESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHGAQSSTSSDLSPMSEQKSLPRRGRSRYHHQ 1831

  Fly  1838 --------------SKKSNGGRSAKSSAACSGVVA----GSESDTSISPSTEFSNMPTYRVPCKS 1884
                          |.|.|...::.::...:...|    .|.|:..:||  ...|:.:.....||
  Fly  1832 QYQFSTNTTPRHHNSNKMNNNTTSNTNTTATNTTATPSTSSNSNKILSP--RGGNLKSISSTFKS 1894

  Fly  1885 SRSSDGRAVVDMFRPDSSTE--------------SNNDQGSPAPERRHN---------TPR-HVL 1925
            ..|........:..|..||:              :||.|.|.:.....:         ||: |.|
  Fly  1895 QDSIQCHIPTLVKSPSISTQQQKQFHKQQLQNSSTNNSQHSSSNPNSSSLKQQQPLLITPKLHQL 1959

  Fly  1926 ---GMGMAMGLGGGGGGGVGGGNGPAEK---------RSAGQRSRKHGSAAQQPSNQTLERRKCP 1978
               |..: :||.|.|...:.....|:.:         ..|.:....|..:.|...:|..::::.|
  Fly  1960 EANGQEL-LGLDGIGNSPLVACMPPSSQFRPIPHKSIMPAHEPPHHHNHSQQSHPHQQQQQQQHP 2023

  Fly  1979 G-----SSNSLDSEVDAETAASLAASIAAMAGS---GAGADLSGGFRPPAGFHDG 2025
            |     |:..|.|:.  .||.:|.....|..||   |...:...||    |:..|
  Fly  2024 GTLLNPSTAMLSSKF--FTAPTLPKXDTANGGSEYVGGAMEAMDGF----GYDSG 2072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	37/76 (49%)
		Ig	56..125	CDD:143165	33/68 (49%)
		I-set	246..337	CDD:254352	27/90 (30%)
		Ig	264..334	CDD:143165	23/69 (33%)
		I-set	345..433	CDD:254352	31/92 (34%)
		Ig	358..431	CDD:143165	22/77 (29%)
		Ig	456..533	CDD:143165	41/76 (54%)
		IGc2	553..619	CDD:197706	25/65 (38%)
		I-set	634..724	CDD:254352	30/91 (33%)
		ig	645..712	CDD:278476	22/67 (33%)
		IG_like	734..815	CDD:214653	31/87 (36%)
		Ig	745..815	CDD:299845	29/76 (38%)
		I-set	820..913	CDD:254352	33/95 (35%)
		Ig	838..920	CDD:299845	34/84 (40%)
		FN3	917..1033	CDD:238020	26/119 (22%)
		FN3	1040..1142	CDD:238020	29/104 (28%)
		fn3	1150..1237	CDD:278470	41/88 (47%)
		FN3	1263..1345	CDD:238020	30/82 (37%)
		Ig	1350..1436	CDD:299845	26/87 (30%)
		IG_like	1358..1436	CDD:214653	19/79 (24%)
		FN3	1441..1530	CDD:238020	30/88 (34%)
		FN3	1542..1620	CDD:238020	25/80 (31%)
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845	38/75 (51%)
		Ig	138..>203	CDD:299845	18/66 (27%)
		I-set	238..327	CDD:254352	27/90 (30%)
		Ig	247..327	CDD:299845	26/80 (33%)
		I-set	332..418	CDD:254352	33/96 (34%)
		IGc2	344..407	CDD:197706	23/73 (32%)
		IG_like	432..517	CDD:214653	48/87 (55%)
		IGc2	436..507	CDD:197706	40/73 (55%)
		I-set	521..610	CDD:254352	36/91 (40%)
		IGc2	533..597	CDD:197706	25/66 (38%)
		Ig	630..699	CDD:143165	23/68 (34%)
		IG_like	714..802	CDD:214653	31/87 (36%)
		Ig	725..802	CDD:299845	29/76 (38%)
		Ig	823..894	CDD:143165	28/71 (39%)
		FN3	906..1006	CDD:238020	26/119 (22%)
		FN3	1013..1111	CDD:238020	29/104 (28%)
		FN3	1119..1209	CDD:238020	42/90 (47%)
		FN3	1219..1313	CDD:238020	36/96 (38%)
		Ig	1336..1402	CDD:143165	18/67 (27%)
		FN3	1409..1498	CDD:238020	30/88 (34%)
		FN3	1515..1588	CDD:238020	24/76 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4915
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.720