DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and dscamb

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio

Alignment Length:	2165	Identity:	640/2165 - (29%)
Similarity:	976/2165 - (45%)	Gaps:	306/2165 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA 112
            ::|.:.|||.|.|.|...||..:.|.|..|.....|||:|.:..||||....||...:...:::.
Zfish    34 VVFSSTTGALVPCPAAAVPPATLRWYLATGEEIYDVPGIRHVHPNGTLQIYGFLPSSFSNLINDN 98

  Fly   113 TYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVASWHRG 177
            ||.|.|.|.:|.:.|:::.:.||.|..:.|.|.:..|..||:|:.||.||..|..||.|.||.:
Zfish    99 TYYCTAENPSGKIRSQDLHIKAVFREPYTVRVADQRVMRGNTAVFKCIIPASVEEYVSVVSWEK- 162

  Fly   178 EEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSK 242
                 ..:|.|:|...::.::|.||:..|:|||.:..:.|...:...||.::|::..|.:.|
Zfish   163 -----DTVSLVSGSRYLITSTGALYILDVQSEDAVNIYRCTTRHRYTGETRQSNSARLLLSE--- 219

  Fly   243 NLAPRTTQKPVMEIHVER-----GNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSR 302
                .....||:....||     |:.|.|||...|:|.|.:.|.|  |::   |:.|..|...|.
Zfish   220 ----PVDSAPVILDGFERKEVMVGHRVELPCKASGHPPPRYRWLR--DNS---PLESDSRYHQSV 275

  Fly   303 TLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGS 367
            :.|||:.....|||.::|:..|.||..::..||.|...:...:.|:....:.|...:..|:.|||
Zfish   276 SGLLIEATRPSDAGSYVCEVWNSFGNAKVVGRLVVKQPLKAVVSPRKVRGSVGSQVSLFCSVTGS 340

  Fly   368 AIDAIDWLHNGKPL-QANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAE 431
            ....|.|..|.:.: |..|...||.:|      .:|:::.:.:.|.|.|||...|.:.|.|.:.:
Zfish   341 DEFDITWYRNAEKIYQGINVRITGINN------ENLVMEGMAKSDGGAYQCFARNGKMSTQDLVQ 399

  Fly   432 LKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDM 496
            :.|.|..|:::..|.|:.|.|...|||.|...|:|.|...|.||..|::..|.|.   :.:.:..
Zfish   400 VVLEDGTPKILSAFSEKVVSPNEPISLVCHVKGTPLPTVTWTLDDDPVIKDSNHR---MDRIITT 461

  Fly   497 SGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCP 561
            .|.|:|:||:||.:..|||:|:|..:||.|||.:.||:||.||..:|.:..:.|:||.|..:||.
Zfish   462 EGHVLSYLNVSHTQVSDGGVYRCTCNNSAGSVSYQARINVRGPASIRPMKNVTAIAGRDTYIHCR 526

  Fly   562 FAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDM 626
            ..|||...|:|.| ...|...||.:.| ..:.|.|.:.||: ..|:|.|||.|.....::..|.:
Zfish   527 IIGYPYYSIKWYK-DSNLLPFNHRQRA-FENNGTLKLSNVQ-NSDEGEYTCYVLVDPEKQIHRSV 588

  Fly   627 QLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSL 691
            .:.|..||:|: ....::...|.|..|.|.|.|||:|:..:|.||...|.:||.:|....:|.|.
Zfish   589 HVTVKVPPLIQ-HSDSQSASIGQRVFIPCVVISGDLPMSITWHKDGRPINASLGVTIDNIDFTSS 652

  Fly   692 LVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPI 756
            |...::|..|:|.|||.|.|.||.|.::.:|.|:|.|.:..:|.|...:.|.::::||.|:|.||
Zfish   653 LRISNLSEIHNGSYTCIARNEAAAVEHSIQLIVKVPPHFEVQPKDQDGIYGKSVTLNCSAKGNPI 717

  Fly   757 PTITWFKGQGKGSKDFKPLS---------MRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIR 812
            |||.|...:|.|...|:|::         :.|.|||:....:.|.|:|:|:.:|::||.:.|::.
Zfish   718 PTIVWNHSKGAGVPQFQPIALNSGSRVQLLENGSLLIKHVLEEDAGFYLCKVSNDVGADISKSMY 782

  Fly   813 INVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRI--DLNNFRFSIAEMKTEK 875
            :.|..||..........:.:.....:.|.|.|::||.:.|.:.:..|  |::.:..::.|:..|
Zfish   783 LTVKIPAMITSYPNTTRAEQGHMTEMSCTAHGEKPIKVRWEKESHIINPDMSRYVVTVKEVGDE- 846

  Fly   876 GVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRP 940
             |.|.|.|.|:.|.|||.:.|||.|.||..:.||.|.||:||| |..:||.||..||:.|.|...
Zfish   847 -VISTLQILHTVREDSGFFSCIAINSYGEDKGIIQLIVQDRPD-PPEVEIREVKDRTIALRWTMG 909

  Fly   941 FDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLT 1005
            ||||||:..|.:.|:..                     :.|..|:.:::.....|.::.|:. |.
Zfish   910 FDGNSPITGYDINYKNK---------------------SASWASSQMTKDVSPQLNQATIIE-LH 952

  Fly  1006 PATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGE 1070
            ||:|:.|||.|.|:|..|..:..:.:.|.|..|..||.:||::......:.|||:.|.:...||.
Zfish   953 PASTYNIRMFAKNQIGESRPSNELTITTDEAPPDGAPQDVQLEAISSQGIKVTWKPPHKHLQNGL 1017

  Fly  1071 LIGYTVNCSEE-----KQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFG 1130
            :..|.| |..|     ....|.|:|..:....|:         ||..|:||::|.|.::|.|..|
Zfish  1018 IRSYQV-CYREFGTGGSPQYNTINVDTTGDIETL---------TLDNLKKYTQYEVRVQAANRAG 1072

  Fly  1131 SGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQID 1195
            .||.|..|..||.|.||...|:||..||.:.:::.:||...|.:...|::.||:::
Zfish  1073 MGPTSEEITITTLEDVPSRPPENVVTTATTPETISLSWSALPKEALNGMLLGYRVI--------- 1128

  Fly  1196 FPAKL---EIKRTSNLET-----YLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAP 1252
            |.|.|   |:....|:.|     .|..|.|.:||||:|||:|..|||:.|..::.:|.:|||..|
Zfish  1129 FWANLPDGELGEIRNITTTKPSLELERLEKYTNYSIQVLAFTRAGDGVRSEQIYTRTKEDVPGPP 1193

  Fly  1253 AAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVT---FES- 1313
            |.:||||.|:..:.:|||.|...||||..|.|:.                 .|.||..   ||:
Zfish  1194 AGVKAAASTSSVVFVSWLPPHKLNGIIRKYIVFC-----------------SNPYPTVISEFEAA 1241

  Fly  1314 --------RSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVL 1370
                    .:|.:|..|..||.|.|:.|.|..:.:|......:|||||.:|...|.......:||
Zfish  1242 PDVYFRRLTNLNQNWQYSIWVVAVTAAGRGNTSEIITVEPQAKAPARILTFSGTVTTPWMRDIVL 1306

  Fly  1371 ECLAVGNPTPRARWLTRDR----PVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEI 1431
            .|.|||:|.|..:||..:.    ||:........|.|:..|..|:...||.|.|.|:|.:|||||
Zfish  1307 PCKAVGDPPPTIKWLKGNNGTPAPVSIDGRRSAHNNGSFVIRTVKAEDSGYYRCVASNNWGSDEI 1371

  Fly  1432 QYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISY-HTAGESWSITELLPENNA 1495
            ...:....||..|::.|...:..||.:.|...|:||:.::||.:.| ....|.|....:.|...:
Zfish  1372 MLNLQVQVPPDQPRLTVTKTTTTSITLFWIPGDNGGSSIRGYILQYSEDNSEEWGSYSISPSERS 1436

  Fly  1496 FTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIAT-NATCVNLKLSSWQ 1559
            :.:..||||..|...::|.|.||.|..||.|...|.||..|....:||.:: |:|.|.|.|..|.
Zfish  1437 YRLENLKCGTWYKFTLTAQNAVGPGRISEIIEAKTHGKEPQFAKDHELFSSINSTRVELNLIGWN 1501

  Fly  1560 NGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEH 1624
            ||||.|..|::|:||:...:||:|..|    ...:.:::: |...|.||:|::...|.||...:.
Zfish  1502 NGGCPIDSFTLEYRPVDTTKWTMVKRD----SLTKSHILY-DLQEATWYELQMRVGNSAGTAEKR 1561

  Fly  1625 YHFSTTNIDGITIP--PPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKH 1687
            ..|:|.|:||.||.  |.||.||:.:...|        .|......|:.:::.:.::.|.|.:..
Zfish  1562 VLFATLNMDGSTIAPLPKSVDPSQENRQGN--------EGLKMMVTIICILVAICMVFIVLLVLR 1618

  Fly  1688 RRTL---------CGPIAE---GYESRTLPGDYKEDHENRRNQQ-------------VYSASPVK 1727
            ||..         ...:||   ...:||      .|..|::.|.             :.....::
Zfish  1619 RRRREQRLKRLRDAKSLAEMLMSKNART------PDTVNKQQQTLRMHIDIPRAQLLIEERDTME 1677

  Fly  1728 TVD----------------KGNESEMYEISPYATFS--------VNGGRTGA-PAKTPTRAVAAQ 1767
            |:|                |...|.:.....|.:.|        |:..|.|. |....|......
Zfish  1678 TIDDRSTVLLTDNDFGETSKQKSSTVTHTVHYQSLSQATGPLVDVSDARPGTNPTARRTAKAGPA 1742

  Fly  1768 TPLDYTMQFKTFG--HPEGENLNATAYPLLPS-SGFGHVKSKSSWHKQRYYNTEDE------STL 1823
            |...|..|: |..  ||...:...|....||: ...|.|..:|..:........|.      ||.
Zfish  1743 TRSRYASQW-TLNRPHPPVSSHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTE 1806

  Fly  1824 SKSMTIVAGSQA-GHSKKSNGGRSAK--------SSAACSGVVAGSESDTSISPSTEFSNMPTYR 1879
            |.|.|....::| .|:|.....|.||        |..:...:.||:...|....|:..|.....|
Zfish  1807 SASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQMTAGTNDYTDSLTSSTPSESGICR 1871

  Fly  1880 VPCKSSRSSDGRAVVDMFRPDSSTESNNDQGSPAPERRHNTPRHVLGMGMAMGLGGGGGGGVGGG 1944
            ......:..|...|::|..|.:.        .||.|..|..|  .|.|...:..|....|
Zfish  1872 FTASPPKPQDASRVMNMAVPKAH--------RPAGELVHLPP--YLRMDFLLNRGAASSG----- 1921

  Fly  1945 NGPAEKRSAGQRSRKHGSAAQQPSNQTLERRKCPGSSNSLDSEVDAETAASLAASIAAMAGSGAG 2009
                 :.:.||       ....|....:.:|.      :|.:...:||.:|      |::.||
Zfish  1922 -----REATGQ-------TCMDPQKSRITKRP------ALLAPTPSETPSS------ALSSSG-- 1960

  Fly  2010 ADLSGGFRPPAGFHDGRE------PGDHSDCEREQRALDLEVQRVMESTGD-AQLAKMDREELTS 2067
                    ||:     ||      ||..|...:.:             .|| ||.||:...:.:.
Zfish  1961 --------PPS-----REAVQQWQPGTASTLPQRE-------------PGDLAQAAKLSSSQESL 1999

  Fly  2068 LLARYHEKKEQE--RLEYTI 2085
            |.:|.|.|:...  ...||:
Zfish  2000 LDSRGHLKQSNNPYAKSYTL 2019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	26/76 (34%)
		Ig	56..125	CDD:143165	25/68 (37%)
		I-set	246..337	CDD:254352	31/95 (33%)
		Ig	264..334	CDD:143165	24/69 (35%)
		I-set	345..433	CDD:254352	23/88 (26%)
		Ig	358..431	CDD:143165	21/73 (29%)
		Ig	456..533	CDD:143165	30/76 (39%)
		IGc2	553..619	CDD:197706	24/65 (37%)
		I-set	634..724	CDD:254352	33/89 (37%)
		ig	645..712	CDD:278476	26/66 (39%)
		IG_like	734..815	CDD:214653	29/89 (33%)
		Ig	745..815	CDD:299845	26/78 (33%)
		I-set	820..913	CDD:254352	28/94 (30%)
		Ig	838..920	CDD:299845	33/83 (40%)
		FN3	917..1033	CDD:238020	34/115 (30%)
		FN3	1040..1142	CDD:238020	32/106 (30%)
		fn3	1150..1237	CDD:278470	31/94 (33%)
		FN3	1263..1345	CDD:238020	25/93 (27%)
		Ig	1350..1436	CDD:299845	33/89 (37%)
		IG_like	1358..1436	CDD:214653	28/81 (35%)
		FN3	1441..1530	CDD:238020	28/89 (31%)
		FN3	1542..1620	CDD:238020	28/78 (36%)
dscamb	XP_009289749.1	I-set	132..198	CDD:254352	24/71 (34%)
		I-set	225..310	CDD:254352	31/89 (35%)
		IGc2	239..300	CDD:197706	23/65 (35%)
		IG_like	320..400	CDD:214653	23/85 (27%)
		IGc2	328..391	CDD:197706	20/68 (29%)
		IG_like	417..501	CDD:214653	34/86 (40%)
		Ig	424..498	CDD:143165	30/76 (39%)
		IG_like	511..592	CDD:214653	27/83 (33%)
		IGc2	518..576	CDD:197706	23/60 (38%)
		I-set	595..685	CDD:254352	34/90 (38%)
		Ig	612..682	CDD:143165	28/69 (41%)
		I-set	689..785	CDD:254352	30/95 (32%)
		Ig7_DSCAM	706..785	CDD:143211	26/78 (33%)
		IG_like	795..883	CDD:214653	28/89 (31%)
		Ig	803..890	CDD:299845	33/89 (37%)
		FN3	887..980	CDD:238020	34/115 (30%)
		FN3	987..1084	CDD:238020	32/106 (30%)
		FN3	1092..1185	CDD:238020	32/101 (32%)
		FN3	1190..1279	CDD:238020	33/105 (31%)
		IGc2	1302..1367	CDD:197706	22/64 (34%)
		FN3	1398..1471	CDD:238020	23/72 (32%)
		FN3	1485..1557	CDD:238020	26/76 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4915
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H66144
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.690