DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and Pxn

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_523891.2 Gene:Pxn / 38326 FlyBaseID:FBgn0011828 Length:1527 Species:Drosophila melanogaster


Alignment Length:1621 Identity:307/1621 - (18%)
Similarity:490/1621 - (30%) Gaps:640/1621 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 RVPTFLLEPAPRL----LFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVP--GLRKISGNGT 94
            |:|..:.:..|||    |..||.. |:......:.|.|...::.:..| ||:|  |..:::....
  Fly   114 RLPATIFQRMPRLEAIFLENNDIW-QLPAGLFDNLPRLNRLIMYNNKL-TQLPVDGFNRLNNLKR 176

  Fly    95 LHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKC 159
            |          |.|              |..:..|..|:::.|| :|:.|:...|    |..:.|
  Fly   177 L----------RLD--------------GNAIDCNCGVYSLWRR-WHLDVQRQLV----SISLTC 212

  Fly   160 AIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLN 224
            |.|:.::        ::|...|                             |...|.|.....| 
  Fly   213 AAPQMLQ--------NQGFSSL-----------------------------GEHHFKCAKPQFL- 239

  Fly   225 GERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAAL 289
                               :||:..|       |..|..|.|.|.:.|.|.|..||...:....|
  Fly   240 -------------------VAPQDAQ-------VAAGEQVELSCEVTGLPRPQITWMHNTQELGL 278

  Fly   290 YPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIE-IRLSVNSYVSVHIL------- 346
            .  ..:|..||....|||::||..|.|.:.|.|.|:.|..|.: :||.||.  ..|.|       
  Fly   279 E--EQAQAEILPSGSLLIRSADTSDMGIYQCIARNEMGALRSQPVRLVVNG--GNHPLDSPIDAR 339

  Fly   347 -------------------------------PQVQIV--NSGGTANFNCTTTGSAIDAIDWLHNG 378
                                           |..|||  :..|....:|..:|.....|.|..||
  Fly   340 SNQVWADAGTPMHGATPLPSPLPSPPHFTHQPHDQIVALHGSGHVLLDCAASGWPQPDIQWFVNG 404

  Fly   379 KPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIY 443
            :.|..:.      .:::..:..||::....:...|.|:|...|...|.||.|.::|.: :||::.
  Fly   405 RQLLQST------PSLQLQANGSLILLQPNQLSAGTYRCEARNSLGSVQATARIELKE-LPEILT 462

  Fly   444 TFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPI----MDVSLHHRFAIGQFVDMSGDVISHL 504
            ....|.::.|....|:|.|.|:|.|...|.|:..|:    .|:.|.:.             .:.|
  Fly   463 APQSQTIKLGKAFVLECDADGNPLPTIDWQLNGVPLPGNTPDLQLENE-------------NTEL 514

  Fly   505 NISHVRPDDGGLYKCVASNSMGSVQHSARLNV---YGPPYVRAIGP--IKAVAGEDIIVHCPFAG 564
            .:...|.:..|:|:|.|.|..|.....|.:.|   ..||.: ||.|  :.|:.|..|.:.|. |.
  Fly   515 VVGAARQEHAGVYRCTAHNENGETSVEATIKVERSQSPPQL-AIEPSNLVAITGTTIELPCQ-AD 577

  Fly   565 YPVE--QIRWEKAHQELTTSNHYELA---SVADGGQLVIKNVE-PGRDQGIYTCIVRSRAGE--- 620
            .|.:  ||.|.  |.......:.:||   .::..|.|.:|||. |  |.|.|.|.::::.|.   
  Fly   578 QPEDGLQISWR--HDGRLIDPNVQLAEKYQISGAGSLFVKNVTIP--DGGRYECQLKNQFGRASA 638

  Fly   621 ------------------------EARRDMQLNVN-------------SPP----VIEPFKFP-- 642
                                    ||.:::.|.:|             :||    ::..|:||  
  Fly   639 SALVTIRNNVDLAPGDRYVRIAFAEAAKEIDLAINNTLDMLFSNRSDKAPPNYGELLRVFRFPTG 703

  Fly   643 --------KNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISA 699
                    ..:.|.....|...|..||                  .:|.|.||:    .|:|:.:
  Fly   704 EARQLARAAEIYERTLVNIRKHVQEGD------------------NLTMKSEEY----EFRDLLS 746

  Fly   700 RHSGKYTCYASNAAAKVNYTAEL----QVRVAPRW-------RYEPMDTAIMLGNTISINCEAEG 753
            |.             .::..|||    :.|..|..       ||..:|.          .|....
  Fly   747 RE-------------HLHLVAELSGCMEHREMPNCTDMCFHSRYRSIDG----------TCNNLQ 788

  Fly   754 YPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEP 818
            :|    ||                                          ||.|....|:   .|
  Fly   789 HP----TW------------------------------------------GASLTAFRRL---AP 804

  Fly   819 ARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTI 883
            ..:|...                     .:.:|||                     ||:   |..
  Fly   805 PIYENGF---------------------SMPVGWT---------------------KGM---LYS 824

  Fly   884 GHSDRHDSGVYRCIAENPYGRAEQIIFLAVQE-RPDTP-SHLEIFEVGSRTVKLSWRRPFDGNSP 946
            ||:             .|..|......:|.:| .||.. :|:          .:.|.        
  Fly   825 GHA-------------KPSARLVSTSLVATKEITPDARITHM----------VMQWG-------- 858

  Fly   947 VLSYLVQYQALKYLQSHGSLAAAGGDWNG-------------HVINVSLPSTSISRSYDSDLRES 998
                    |.|.:...|...:.:...|:|             :.|.|......:......|:..|
  Fly   859 --------QFLDHDLDHAIPSVSSESWDGIDCKKSCEMAPPCYPIEVPPNDPRVRNRRCIDVVRS 915

  Fly   999 AIVAGLTPATTFLIRMQAINEIER-SAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIP 1062
            :.:.|....:.|...:|...:|.: ::|.:|..:.....|..:...|:..|.|            
  Fly   916 SAICGSGMTSLFFDSVQHREQINQLTSYIDASQVYGYSTAFAQELRNLTSQEG------------ 968

  Fly  1063 PRESWNGELIGYTVNCSEEKQNINFISV---------VNSSLKSTIVSG---------------- 1102
                    |:...|:...:|..:.|.:.         ::.:..|..|||                
  Fly   969 --------LLRVGVHFPRQKDMLPFAAPQDGMDCRRNLDENTMSCFVSGDIRVNEQVGLLAMHTI 1025

  Fly  1103 WATTKATLRGLRKYSRYAVTIRAMNSFGSG---------------------PWSAAIFGTTA--- 1143
            |         :|:::|.|..::.:||...|                     .|...|.|.:.   
  Fly  1026 W---------MREHNRIASKLKQINSHWDGDTLYQEARKIVGAQMQHITFKQWLPLIIGESGMEM 1081

  Fly  1144 ----EGV-PEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIK 1203
                :|. |:..|...|..|.::           |:|      |:.|: .||:|:::        
  Fly  1082 MGEYQGYNPQLNPSIANEFATAA-----------LRF------GHTII-NPILHRLN-------- 1120

  Fly  1204 RTSNLETYL-----H-TLHKASNYSIRVLAYTATGD----GLASHPLFCQTDDDVPDAPAAIK-- 1256
                 ||:.     | .||||.....| |||....|    |..:.|...:|.|...:.....|  
  Fly  1121 -----ETFQPIPQGHLLLHKAFFAPWR-LAYEGGVDPLMRGFLAVPAKLKTPDQNLNTELTEKLF 1179

  Fly  1257 ----AAALTADSILISWLTPKNRNGIISHYTVYSR------------EAGRKGQAKTHMVRVDEN 1305
                |.||...:|.|.    :.|:..:..|.||.:            .||....|:......:..
  Fly  1180 QTAHAVALDLAAINIQ----RGRDHGMPGYNVYRKLCNLTVAQDFEDLAGEISSAEIRQKMKELY 1240

  Fly  1306 GYP--VTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGL 1368
            |:|  |......:.|:|:            ||                     |:|       |.
  Fly  1241 GHPDNVDVWLGGILEDQV------------EG---------------------GKV-------GP 1265

  Fly  1369 VLECLAVGNPTPRAR---WLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLF 1426
            :.:||.| ....|.|   .|..:.|..||| .::|........||...:..|:.....|:|
  Fly  1266 LFQCLLV-EQFRRLRDGDRLYYENPGVFSP-EQLTQIKQANFGRVLCDVGDNFDQVTENVF 1324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 13/78 (17%)
Ig 56..125 CDD:143165 12/70 (17%)
I-set 246..337 CDD:254352 30/91 (33%)
Ig 264..334 CDD:143165 24/70 (34%)
I-set 345..433 CDD:254352 23/127 (18%)
Ig 358..431 CDD:143165 16/72 (22%)
Ig 456..533 CDD:143165 19/80 (24%)
IGc2 553..619 CDD:197706 21/71 (30%)
I-set 634..724 CDD:254352 19/107 (18%)
ig 645..712 CDD:278476 12/66 (18%)
IG_like 734..815 CDD:214653 9/80 (11%)
Ig 745..815 CDD:299845 8/69 (12%)
I-set 820..913 CDD:254352 11/92 (12%)
Ig 838..920 CDD:299845 14/82 (17%)
FN3 917..1033 CDD:238020 19/130 (15%)
FN3 1040..1142 CDD:238020 21/147 (14%)
fn3 1150..1237 CDD:278470 23/96 (24%)
FN3 1263..1345 CDD:238020 16/95 (17%)
Ig 1350..1436 CDD:299845 19/80 (24%)
IG_like 1358..1436 CDD:214653 18/72 (25%)
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
PxnNP_523891.2 LRR_RI 51..>161 CDD:238064 12/48 (25%)
leucine-rich repeat 54..77 CDD:275380
LRR_8 55..112 CDD:290566
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..125 CDD:275380 2/10 (20%)
LRR_8 124..184 CDD:290566 18/85 (21%)
leucine-rich repeat 126..149 CDD:275380 5/23 (22%)
LRR_4 148..185 CDD:289563 11/61 (18%)
leucine-rich repeat 150..173 CDD:275380 6/23 (26%)
Ig 240..325 CDD:299845 31/93 (33%)
IG_like 242..325 CDD:214653 30/91 (33%)
I-set 366..450 CDD:254352 21/89 (24%)
Ig 384..451 CDD:143165 16/72 (22%)
I-set 458..546 CDD:254352 24/100 (24%)
Ig 472..536 CDD:299845 19/76 (25%)
I-set 553..644 CDD:254352 27/96 (28%)
Ig 570..643 CDD:299845 21/77 (27%)
An_peroxidase 777..1317 CDD:281139 130/789 (16%)
peroxidasin_like 898..1338 CDD:188658 97/534 (18%)
VWC 1465..1523 CDD:278520
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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