DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and PTPRQ

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_016874762.1 Gene:PTPRQ / 374462 HGNCID:9679 Length:2536 Species:Homo sapiens


Alignment Length:2260 Identity:418/2260 - (18%)
Similarity:712/2260 - (31%) Gaps:851/2260 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LLATSGLR--VPTFLL-----EPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGL 86
            ::...||:  .||.|:     :|:..|::|.:  ....|         ::|.|.:|.        
Human    81 IMTNKGLKRSHPTVLMVSTYPDPSDLLIWGQE--ENTIC---------LSWKLSEGG-------- 126

  Fly    87 RKISGNGTLHFPPFLAQYYRTDVHE-----ATYRCRASNEAGTV-LSRNVQVHAVVRRQFHVHVE 145
                      |..|...|......|     ..|..:|..:..|: :....||..|..:.:.|.|.
Human   127 ----------FEKFQISYCMPSRQEKLIKVIVYGNKAKVKKLTLGMDYMFQVKKVKGKGYSVSVM 181

  Fly   146 NTEVYLGNSALIKCAIPEYVRPY----------VRVASWH--RGEEILLPDLSDV------AGRY 192
                   ....||...||.:|.:          ..:.|.|  |.:..|:||...|      .|.|
Human   182 -------KKVPIKPEQPEKLRAFNISTHSFSLHWSLPSGHVERYQVDLVPDSGFVTIRDLGGGEY 239

  Fly   193 ------VVLAASGDLYVRSVRSEDGLMKFSCLVTNT--------LNGERQRSDAVMLQVKELSKN 243
                  ||.....|:.:.|:.:.........:.||.        |.|||..|..::     ||.|
Human   240 QVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL-----LSWN 299

  Fly   244 LAPRTTQKPVMEIHVERGNDVHLPCNIQGNPF--PIFTWYRVSDSAALYPIPSSQRVILSR---- 302
            ..|....:.:.  ::.:..:|   |     |:  .::|..|..        |.|..|:|:.    
Human   300 TPPNPNGRIIS--YIVKYKEV---C-----PWMQTVYTQVRSK--------PDSLEVLLTNLNPG 346

  Fly   303 TLLLIKNADERDAGKWICQASNQFGEQRIE------IRLSVNSYVSVHILPQVQIVNSGGTANFN 361
            |...||.|.|..||  |...|:.|..|..|      :.|:|.:|                     
Human   347 TTYEIKVAAENSAG--IGVFSDPFLFQTAESAPGKVVNLTVEAY--------------------- 388

  Fly   362 CTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASA 426
               ..||:..|.:|    |.|.|..:|:.:.:::. ::|.::|::|..|...:            
Human   389 ---NASAVKLIWYL----PRQPNGKITSFKISVKH-ARSGIVVKDVSIRVEDI------------ 433

  Fly   427 QAMAELKLGDTVPEL---IYTFIEQNVRPGPLIS-----LKCSASGSPPPQ----FAWLLDSQPI 479
                   |...:||.   ..:|:.....|.|.:.     .:.:.|.|...|    ..|   .:||
Human   434 -------LTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVW---KEPI 488

  Fly   480 MDVSLHHR------FAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMG------------ 526
            ..|..|.|      |.:......:|.:.|.:..:.....:|....||..|..|            
Human   489 SFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTI 553

  Fly   527 -SVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASV 590
             :.:.|.|:.:|||.     |.|...:.:|:                :.|...||....|::...
Human   554 VTGKFSYRVELYGPS-----GRILDNSTKDL----------------KFAFTNLTPFTMYDVYIA 597

  Fly   591 ADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITC 655
            |:                       :.||...:.:  ::|.:||.:....|...|.|....|:. 
Human   598 AE-----------------------TSAGTGPKSN--ISVFTPPDVPGAVFDLQLAEVESTQVR- 636

  Fly   656 AVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTA 720
                      .:|||...  |:.:                                    :|   
Human   637 ----------ITWKKPRQ--PNGI------------------------------------IN--- 650

  Fly   721 ELQVRV-APRWRYEPMDTAIMLGNT-ISINCEAEGYPI---------PTITWFKGQGKGSKDFKP 774
            :.:|:| .|       :|.|:|.|| ::.|.|....|:         |.:..::|..:.|.|.  
Human   651 QYRVKVLVP-------ETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDL-- 706

  Fly   775 LSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLD 839
                 |||                          .|...|.:....|  .|||.:..:..||.. 
Human   707 -----HSL--------------------------ATFIYNSHPDKNF--PARNRAEDQTSPVVT- 737

  Fly   840 CHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGR 904
                         |:|....|:...:.|....:.....:..:::        ..:..:.|.|   
Human   738 -------------TRNQYITDIAAEQLSYVIRRLVPFTEHMISV--------SAFTIMGEGP--- 778

  Fly   905 AEQIIFLAVQERPDTPSHLEIF---EVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSL 966
               ...|:|:.|...||.::|.   .:.|.::.|.|..|...|..:..|.:....|.        
Human   779 ---PTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELD-------- 832

  Fly   967 AAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEA--I 1029
                       .|.:...|:|..|:        ::.||...|.:.:|:.|...:..|:.:|.  |
Human   833 -----------TNRAFQITTIDNSF--------LITGLKKYTKYKMRVAASTHVGESSLSEENDI 878

  Fly  1030 VLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSS 1094
            .::|.|:.|..:|.:|:|......|:.:.|.  |.|..||.:|.|.|    ..:||:.:.:.|:|
Human   879 FVRTSEDEPESSPQDVEVIDVTADEIRLKWS--PPEKPNGIIIAYEV----LYKNIDTLYMKNTS 937

  Fly  1095 LKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGT-TAEGVPEAAPQNVNCTA 1158
                      ||...||.||.::.|.:::|:...||.|...:::... |:|.||::||:|:....
Human   938 ----------TTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKN 992

  Fly  1159 LSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKR----------TSNLETYLH 1213
            :||..:::|:|.|  ....||||.|.|.               :||          |::|...:.
Human   993 ISSGEIELSFLPP--SSPNGIIQKYTIY---------------LKRSNGNEERTINTTSLTQNIK 1040

  Fly  1214 TLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAP-------------------------- 1252
            .|.|.:.|.|.|.|.|..|:|:.|.|:...|::|.||:|                          
Human  1041 VLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNG 1105

  Fly  1253 ------------AAIKA------------------------------------------------ 1257
                        :::|.                                                
Human  1106 IILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAP 1170

  Fly  1258 ---------AALTADSILISWLTPKNRNGIISHYTVYSRE-AGRKGQAKT-HMVRVDENGYPVTF 1311
                     |.|::.||::.|..|...||||.:|:||.|. :|...|..| |.|..|.:...|:.
Human  1171 SDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST 1235

  Fly  1312 ESRSLAENQMYEFWVSASTSVGEGEPTS-VIAQATNTRAPARIASFGQVVRKAVGT--------- 1366
            ....|.....|.||::||||||.|..:| :|...|:...|....  |.:..:::.:         
Human  1236 IIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFV--GNLTYESISSTAINVSWVP 1298

  Fly  1367 -----GLVLECLA-VGNPTP---RARWLTRDRPVTFSPFYEVTNEGNLKI-HRVEGSLSGNYTCT 1421
                 |||...:: :...||   |...:|.:|.:.|....:.| :..||| ...|...|..||. 
Human  1299 PAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYT-DYILKITPSTEKGFSDTYTA- 1361

  Fly  1422 ANNLFGSDEIQYQVIAMKPPSAPQI-IVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWS 1485
                    ::..:.....|.::|.| ..:..|:.|:.:|||.|......:..|.::.....|::|
Human  1362 --------QLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYS 1418

  Fly  1486 -ITE----LLPENNAFTI----------SGL-------------------------KCGNQYI-I 1509
             ||.    :|.|.:.||:          .||                         .|.:.:: :
Human  1419 FITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1483

  Fly  1510 KMSAHNMVG-----------------------SGVASE--------------EINVWTK-GKASQ 1536
            |.|...:.|                       ||..:|              .::.:|| |..:|
Human  1484 KWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQ 1548

  Fly  1537 APNANEL--------IATNATCVNLKLSSWQ------------NGGCSIHHFSIEHRPL----GD 1577
            ..|..:.        :..|..|:   .:|||            ||..:.:..::|....    .|
Human  1549 FSNVVKFTTQESVPDVVQNMQCM---ATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQD 1610

  Fly  1578 IRWTVV-----TSDI------SNAEENRENLIFCDFLPA-------------------------- 1605
            ..:|.:     ||.:      ::|.|..|:......||.                          
Human  1611 HMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP 1675

  Fly  1606 ------------------------------------------------------KWYQLRISATN 1616
                                                                  :||:.:::|:.
Human  1676 DTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAAST 1740

  Fly  1617 DAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITI 1681
            :||     |..::..|...|:|.|...|.||                       |.::..|..:|
Human  1741 NAG-----YGNASNWISTKTLPGPPDGPPEN-----------------------VHVVATSPFSI 1777

  Fly  1682 ALTIKHRRTLCGPIAEGYESRTLPGD------YKEDHENR----RNQQVYSA-SPVKTVDKGNES 1735
            :::......:.||.....:.:::..|      .|.:.||:    ::.::::. |.|.|...||.|
Human  1778 SISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNIS 1842

  Fly  1736 EMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGF 1800
            ..|.....:...:......||...|......:.|.:.|....||..|...|.|...|..|     
Human  1843 AAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL----- 1902

  Fly  1801 GHVKSKSSWHKQRYYNTEDE--------STLSKSMTIV----AGSQAGHS 1838
                         .|..:|.        |.:.|:.|.|    .|.:.||:
Human  1903 -------------VYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHT 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 12/82 (15%)
Ig 56..125 CDD:143165 10/73 (14%)
I-set 246..337 CDD:254352 23/102 (23%)
Ig 264..334 CDD:143165 21/81 (26%)
I-set 345..433 CDD:254352 12/87 (14%)
Ig 358..431 CDD:143165 12/72 (17%)
Ig 456..533 CDD:143165 18/104 (17%)
IGc2 553..619 CDD:197706 6/65 (9%)
I-set 634..724 CDD:254352 10/89 (11%)
ig 645..712 CDD:278476 7/66 (11%)
IG_like 734..815 CDD:214653 16/90 (18%)
Ig 745..815 CDD:299845 11/78 (14%)
I-set 820..913 CDD:254352 13/92 (14%)
Ig 838..920 CDD:299845 9/81 (11%)
FN3 917..1033 CDD:238020 22/120 (18%)
FN3 1040..1142 CDD:238020 27/102 (26%)
fn3 1150..1237 CDD:278470 27/96 (28%)
FN3 1263..1345 CDD:238020 32/84 (38%)
Ig 1350..1436 CDD:299845 19/104 (18%)
IG_like 1358..1436 CDD:214653 17/96 (18%)
FN3 1441..1530 CDD:238020 26/167 (16%)
FN3 1542..1620 CDD:238020 21/192 (11%)
PTPRQXP_016874762.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.