DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and Cxadrl1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_008764801.1	Gene:	Cxadrl1 / 361873	RGDID:	735201	Length:	393	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	89/387 - (22%)
Similarity:	143/387 - (36%)	Gaps:	94/387 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 VKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNI------QGNPFPIFTWYRVSDS--------A 287
            |.:|..:::..|.::.|.|   ..|..|||||..      || |..| .|.|:|..        .
  Rat    13 VTDLIGSVSITTPEQIVQE---AGGEIVHLPCMFTLSPEDQG-PLDI-EWLRLSGPNNEAIDHVV 72

  Fly   288 ALYPIP----------------SSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLS 336
            .||...                :|..|:.....:.|:|....|:|.:.|:.....|..:..::|:
  Rat    73 ILYAADKIYSDFYQDLKGRVHFTSNDVVSGDASIKIRNVRPADSGTYQCKVKKAPGVAKTTVQLT 137

  Fly   337 VNSYV-SVHILPQVQIVN--SGGTANFNCTTTGSAIDA----IDWLHNGKPLQANN------ALT 388
            |.... ||:|....|.|.  .|.|.:..|..|..:.|.    ::||....|   ||      .:.
  Rat   138 VIDITGSVNITTPEQTVQEAQGETVHLPCIFTYVSKDQGPLDVEWLRLSGP---NNEAIDHVVIL 199

  Fly   389 TGRDNIR------------FLSK------SSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLG 435
            ...|.|.            |.|.      :|:.:.||...|.|.|||.|:..........:|.:.
  Rat   200 YSADKIHDDVYPDLKGRVYFTSNDIRSGDASINITNVRLSDVGTYQCKVKTYPGIVNRNLQLAVT 264

  Fly   436 DTVPELIYTFIEQNVRP--GPLISLKCSASGSPP---PQFA-WLLDSQPIMDVSLHHRFAI---- 490
            :.:..:..|..||.::.  |..:.|.|..:..|.   |.|. |:..:.|..:| ::..|.:
  Rat   265 NILGSVSITTPEQTIQKARGETVHLPCMFTLIPEDRGPLFIDWIQLTGPQNEV-VNRMFIVYLAD 328

  Fly   491 ----GQFVDMSGDVI----------SHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYG 538
                ..:.||.|.|.          :.:||::|:..|.|.|:|..|:..|:.|.:.:|.|.|
  Rat   329 KVYDNFYQDMKGRVYFTNNDVRSGDASINITNVQLSDAGTYQCGVSHDFGTAQRTIQLTVVG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	27/120 (23%)
		Ig	264..334	CDD:143165	22/99 (22%)
		I-set	345..433	CDD:254352	26/117 (22%)
		Ig	358..431	CDD:143165	21/100 (21%)
		Ig	456..533	CDD:143165	23/98 (23%)
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Cxadrl1	XP_008764801.1	IG_like	25..138	CDD:214653	26/117 (22%)
		V-set	34..138	CDD:284989	24/105 (23%)
		V-set	149..264	CDD:284989	26/117 (22%)
		IG_like	150..263	CDD:214653	26/115 (23%)
		V-set	274..389	CDD:284989	27/115 (23%)
		IG_like	277..388	CDD:214653	26/111 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910