DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and Cadm3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_006250385.1	Gene:	Cadm3 / 360882	RGDID:	1307035	Length:	430	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	76/313 - (24%)
Similarity:	123/313 - (39%)	Gaps:	65/313 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 VAGEDIIVHCPFAGYPVEQIRWEKAHQ----------------ELTTSNHYELASVADGGQLVIK 599
            |||..:::.|....:....::|....|                :|.:|..:||:       :.|.
  Rat    73 VAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLVSSTPHELS-------ISIS 130

  Fly   600 NVEPGRDQGIYTCIVRSRAGEEARRDMQ-LNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMP 663
            ||... |:|.|||.:.:.....|:..:. |.:...|:|..:|  .:|:|...|.:.|. |||..|
  Rat   131 NVALA-DEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYK--SSLREKETATLNCQ-SSGSKP 191

  Fly   664 -IYFSWKKDDSSI----------PSSLQITEKKEEFYSLLVFKD-------ISARH-SGKYTCYA 709
             ...:|:|.|..:          |:....|....  .|..|.:|       .|..| |.|....:
  Rat   192 AAQLAWRKGDQELHGDQTRIQEDPNGKTFTVSSS--VSFQVTRDDDGANVVCSVNHESLKGADRS 254

  Fly   710 SNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP-TITWFKGQGKGSKDFK 773
            ::...:|.||....:|..|....|        |..:.::||..|.|:| ...|.|   :||:  .
  Rat   255 TSQRIEVLYTPTAMIRPEPAHPRE--------GQKLLLHCEGRGNPVPQQYVWVK---EGSE--P 306

  Fly   774 PLSMRNHS-LLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSA 825
            ||.|...| |:......:|.|.|.|.||:.:|: ......:|||:|:....|:
  Rat   307 PLKMTQESALIFPFLNKSDSGTYGCTATSNMGS-YTAYFTLNVNDPSPVPSSS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706	16/81 (20%)
		I-set	634..724	CDD:254352	26/108 (24%)
		ig	645..712	CDD:278476	20/85 (24%)
		IG_like	734..815	CDD:214653	22/82 (27%)
		Ig	745..815	CDD:299845	21/71 (30%)
		I-set	820..913	CDD:254352	1/6 (17%)
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Cadm3	XP_006250385.1	Ig1_Necl-1	64..158	CDD:143290	19/92 (21%)
		IG_like	68..>142	CDD:214653	16/76 (21%)
		IG_like	175..244	CDD:214653	16/71 (23%)
		Ig	179..261	CDD:299845	18/84 (21%)
		Ig_2	269..348	CDD:290606	25/92 (27%)
		IG_like	271..348	CDD:214653	24/90 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910