DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and igdb-1

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_502387.2 Gene:igdb-1 / 3565301 WormBaseID:WBGene00011418 Length:1029 Species:Caenorhabditis elegans


Alignment Length:1183 Identity:229/1183 - (19%)
Similarity:397/1183 - (33%) Gaps:339/1183 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   744 TISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHS-LLLNLATDNDEGYYMCQATNEIGAGL 807
            ||:..|.||.   |.::.....|           |||: ..|.....:|.......:|.|:  |:
 Worm    15 TIATTCRAEW---PKVSPCIADG-----------RNHTDCCLKKGVQHDCLEICSGSTKEL--GV 63

  Fly   808 KKTIRINVNEPARFEQSARNISSRRNDP--VT---LDCHAKGDEPITIGWTQNNGRIDL-NNFRF 866
            ...:.:|::..|.::...:...:..:.|  ||   |..|:     :|:.||:.|....| .|:..
 Worm    64 HSVLCLNLDLQAIYQCIRQGYETHPSAPGNVTISELTAHS-----VTVQWTEPNSNAHLVENYTL 123

  Fly   867 SIAE------MKTEKGV-----------DSQ--LTI-GHSDR----------------------- 888
            .|.:      ::|.|.|           ||:  ||: .||..                       
 Worm   124 FIRKNEHGEAVRTVKNVISPHVELGLDPDSEYVLTLQSHSANGTSLPSTAKLFSTLPTTRPPLCT 188

  Fly   889 -------HDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSP 946
                   :|..|..|.|.||                 .|:.......||   .||:..|.||...
 Worm   189 IGEPIYMNDGRVMICDAVNP-----------------CPNGFRCTGAGS---DLSYCCPHDGTHS 233

  Fly   947 VLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPST----------SISRSYD-------SD 994
            ...:....:..|..:|..|...         .|::||.:          ..|..:|       .:
 Worm   234 SEEFTSCCKEQKMPESCMSSCQ---------YNMTLPESCKENLNTWVQCASEGHDHLRCCLQEE 289

  Fly   995 LRESAIVAGLTPATTFLIRMQAINEIE--RSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIV 1057
            :.:....|.:.|.|  :...:..:|:.  |:.::.|      .:|...|..||:|.:..:....:
 Worm   290 VSKPCQTACMHPFT--VPADECFSEVSKYRTCFSAA------HQALPAAVRNVEVSSISKDSATI 346

  Fly  1058 TWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLR--GLRKYSRYA 1120
            :|     |.....:|.:.|...|:..|:  |...|||..            ..|  .|.....|:
 Worm   347 SW-----EDLEANIIVFRVQLFEKGGNL--IKTENSSAD------------IFRFIDLEPNKDYS 392

  Fly  1121 VTIRAMNSFGSGP--WSAAIFGTTA---EGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGII 1180
            |.:.|:|..|.||  |:|......|   ||....||:.:..:..|...:.::|  .|:    .:.
 Worm   393 VRVTAINFLGEGPPSWNATFTTKPAQIYEGDRPVAPEKLRISWNSGPRVNVTW--DPV----SVR 451

  Fly  1181 QGYKILYRPIVHQIDFPAKLEIKRTSNLET--------YLHTLHKASNYSIRVLAYTATGDGLAS 1237
            :..:::.:||.:.|.:   |:.:::|...|        .:..|.|.:.|.:.|.|........:|
 Worm   452 RNAEVVTKPIEYTIYY---LDTEQSSTWTTLRTNQTWVVMRDLRKDALYYVYVTAKEDNRTSRSS 513

  Fly  1238 HPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRV 1302
            ..:......|.|..|         ..:|:|.   |.:::|:.|        .|.|......:..:
 Worm   514 SIITILAQKDSPGLP---------EPTIVIE---PDHKDGVFS--------PGEKISINCSLPNI 558

  Fly  1303 DEN-GYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVV-RKAVG 1365
            .:: ...:|..|. :.:|.....||...|...|...|:..| .::|.....:|....|: |||..
 Worm   559 KKHLNIDLTVGSH-VVQNDHGALWVILETEADEAMDTATCA-VSDTDGRQHVAMKHLVLERKASV 621

  Fly  1366 T------------GLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNEG--NLK---------- 1406
            |            .:.:||:..|...        |..::|....:..:.|  |||          
 Worm   622 TMKKDKIRVLDDQSVEIECIYRGGGL--------DPKISFEKDGKKASRGFLNLKKTEAGYVAKW 678

  Fly  1407 -IHRVEGSLSGNYTCTANNLFG-----SDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDD 1465
             |.:|:...:|.|.|...:..|     |.|:.:....:  |..|::|:|....:.|.        
 Worm   679 HIRKVKQEDAGFYKCVVTSSDGSRVEASSEVIFSTETL--PVNPKLILQCCEDEGIT-------- 733

  Fly  1466 GGAPLQGYTISYHTAGESWSITELLPEN---NAFTISGLKCGNQYIIKMSAHNMVGSGVASEEIN 1527
             |..||...|..         |.|..:|   ..|.:|.|||.:.  |:..:...:.|||.|:.:.
 Worm   734 -GDCLQACNIGR---------TSLSIKNQNCTRFAVSLLKCASD--IRDHSDCCIASGVTSKCLP 786

  Fly  1528 VWTKGKASQAPNANELIATNATC--------------VNLKLSSWQNGGCSIH----------HF 1568
            :.:....|...:.:|...:..||              |.:|.|   .|..:|.          :|
 Worm   787 LCSGDSFSPDIDCSEHAVSIMTCSVKSHEHAPSEVSNVRIKAS---EGKVNIEWDYPLTKDYKYF 848

  Fly  1569 SIEHRPLGDIR--WTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTN 1631
            ::.:|...|..  |    ..:...::|.|    .|..|::.|::.|.|.|..|.:...|      
 Worm   849 AVYYRKAHDDHEDW----HKLKTIQQNIE----LDVDPSEDYEVGILAANALGHSRLMY------ 899

  Fly  1632 IDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTI-KHRRTLCGPI 1695
                     |..|.:::...:.  |...:|..|    |||:::...::...|.: ..||.|..||
 Worm   900 ---------SAIPKDSEPRRSA--SKGSSSAFW----IVVILVVFGVLIAGLAVLSKRRELPYPI 949

  Fly  1696 AEGYESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPYATFSVNGGRTGAPAKTP 1760
            .:....|..|.......||....:.:.         |.|.|:..:...||       ||..|.|.
 Worm   950 GKFIGRRNDPNQPTVAFENPAYGEPWG---------GAEVEIRGLGGSAT-------TGTAAATQ 998

  Fly  1761 TRAVAAQTPLDYT 1773
            :...:|....:.|
 Worm   999 SEWQSANLEANST 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352
Ig 358..431 CDD:143165
Ig 456..533 CDD:143165
IGc2 553..619 CDD:197706
I-set 634..724 CDD:254352
ig 645..712 CDD:278476
IG_like 734..815 CDD:214653 15/71 (21%)
Ig 745..815 CDD:299845 14/70 (20%)
I-set 820..913 CDD:254352 27/148 (18%)
Ig 838..920 CDD:299845 24/132 (18%)
FN3 917..1033 CDD:238020 22/134 (16%)
FN3 1040..1142 CDD:238020 25/105 (24%)
fn3 1150..1237 CDD:278470 16/94 (17%)
FN3 1263..1345 CDD:238020 16/82 (20%)
Ig 1350..1436 CDD:299845 23/116 (20%)
IG_like 1358..1436 CDD:214653 22/108 (20%)
FN3 1441..1530 CDD:238020 22/91 (24%)
FN3 1542..1620 CDD:238020 20/103 (19%)
igdb-1NP_502387.2 DB 1..80 CDD:279948 17/80 (21%)
FN3 88..178 CDD:238020 21/94 (22%)
Lustrin_cystein 187..227 CDD:291299 11/59 (19%)
DB 240..321 CDD:279948 13/91 (14%)
FN3 328..414 CDD:238020 25/104 (24%)
FN3 425..518 CDD:238020 17/101 (17%)
ig 628..701 CDD:278476 14/80 (18%)
DB 726..809 CDD:279948 20/102 (20%)
FN3 818..895 CDD:214495 18/87 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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