DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and LRIT3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	717	Identity:	134/717 - (18%)
Similarity:	233/717 - (32%)	Gaps:	241/717 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1040 EAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWA 1104
            |.|:|:.|.|   .:|.:...:..|.|  .|...|.|       .:.::.|..:|:.|...|.:.
Human    50 ELPTNLPVDT---VKLRIEKTVIRRIS--AEAFYYLV-------ELQYLWVTYNSVASIDPSSFY 102

  Fly  1105 TTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAA----------IFGTTAEGVP-EAAPQNVNCTA 1158
            ..| .|..||...         ||..:.||::.          :.......|| ||.....|...
Human   103 NLK-QLHELRLDG---------NSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAY 157

  Fly  1159 LSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNY-- 1221
            |...|.:::.|.|                       ||           ||::.|.:...|..
Human   158 LDLSSNRLTTLPP-----------------------DF-----------LESWTHLVSTPSGVLD 188

  Fly  1222 --SIRVLAYTATGDGLASHPLFCQTD-DDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYT 1283
              ..|::.      ||..:|.||... ..:.:....:..|.:..|. |::...|:...||:
Human   189 LSPSRIIL------GLQDNPWFCDCHISKMIELSKVVDPAIVLLDP-LMTCSEPERLTGIL---- 242

  Fly  1284 VYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTR 1348
                                       |: |:..|:.:              :| ||:..||.
Human   243 ---------------------------FQ-RAELEHCL--------------KP-SVMTSATK-- 262

  Fly  1349 APARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRD-RPVTFSPFYEVTNEG----NLKIH 1408
                       :..|:|:.::|.|.|.|.|||:..|...| .||.::...|...||    .:.:.
Human   263 -----------IMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLT 316

  Fly  1409 RVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGY 1473
            .:....:|:|.|.|.||.|..|....|..:...:.|      ...|:...:.|.|:....|..|.
Human   317 GISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTP------IPPDTSERTGDHPEWDVQPGSGR 375

  Fly  1474 TISYHTAG-----------ESWSITELLPENNA-FTISGLKCGNQYIIKMSAHNMVGSGVASE-- 1524
            :.|..:|.           .|:|.:.|.|.:.| |::|......     :|:...:.:.:::.
Human   376 STSVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFSSST-----VSSTTTLSTSISASTT 435

  Fly  1525 -------------EINVWTKGKASQAPNANE-------------LIATNATCVNLKLSSWQNGGC 1563
                         :.|:......|:.|.|:.             |..|||...||::.|
Human   436 MANKRSFQLHQGGKRNLKVAKNGSKLPPASTSKKEELALLDQTMLTETNAAIENLRVVS------ 494

  Fly  1564 SIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATN-DAGKTTEHYHF 1627
                   |.:....:.|.::.:..::|         ...|.:|:....:...| |:.|
Human   495 -------ETKESVTLTWNMINTTHNSA---------VTVLYSKYGGKDLLLLNADSSK------- 536

  Fly  1628 STTNIDGI--------TIPPPSVFPSENDLMNNLINSTNPTSGD---WFATLIVVVIITVSIITI 1681
            :...|||:        .:.|..|.|.::..   :..||....||   |  :|::||..|..::.:
Human   537 NQVTIDGLEPGGQYMACVCPKGVPPQKDQC---ITFSTERVEGDDSQW--SLLLVVTSTACVVIL 596

  Fly  1682 AL 1683
            .|
Human   597 PL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020	23/111 (21%)
		fn3	1150..1237	CDD:278470	14/90 (16%)
		FN3	1263..1345	CDD:238020	11/81 (14%)
		Ig	1350..1436	CDD:299845	24/90 (27%)
		IG_like	1358..1436	CDD:214653	24/82 (29%)
		FN3	1441..1530	CDD:238020	17/115 (15%)
		FN3	1542..1620	CDD:238020	14/91 (15%)
LRIT3	NP_940908.3	LRR 1	56..79		6/27 (22%)
		leucine-rich repeat	59..82	CDD:275378	7/34 (21%)
		LRR_8	61..117	CDD:290566	15/74 (20%)
		LRR 2	80..103		5/29 (17%)
		leucine-rich repeat	83..106	CDD:275378	5/23 (22%)
		LRR 3	104..128		8/33 (24%)
		LRR_8	105..165	CDD:290566	15/69 (22%)
		LRR_4	105..146	CDD:289563	9/50 (18%)
		leucine-rich repeat	107..130	CDD:275378	7/31 (23%)
		LRR 4	129..151		4/21 (19%)
		LRR_4	131..170	CDD:289563	8/38 (21%)
		leucine-rich repeat	131..154	CDD:275378	4/22 (18%)
		LRR 5	152..175		8/56 (14%)
		leucine-rich repeat	155..168	CDD:275378	2/12 (17%)
		Ig	267..345	CDD:299845	24/77 (31%)
		IG_like	267..345	CDD:214653	24/77 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		5/29 (17%)
		FN3	486..550	CDD:214495	14/92 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900