DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and dpr19

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	74/329 - (22%)
Similarity:	122/329 - (37%)	Gaps:	53/329 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGT 357
            |....:.||..|||:.:... |.|| |..:.|.||.   .::...|:..:..::.|     .||.
  Fly     3 PKRWHLHLSCFLLLLSSTFS-DVGK-ITSSQNHFGN---TLQSQFNTKNNTRVIAQ-----KGGL 57

  Fly   358 ANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKS-------SLLVQNVGRRDRGVY 415
            |...|....::...:.|:...........|:|...:.|||.:.       ||.::.|...|||.|
  Fly    58 AILPCVVKVNSPATVSWIRRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFY 122

  Fly   416 QCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSAS-GSPPPQFA-WLLDSQP 478
            :|.: :...:...:.|||:.:.|.| |.:..|.::.....:.|:|... .:..|.|. |..||:.
  Fly   123 ECQL-SIYPTQSIVIELKIVEAVAE-ISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDSKM 185

  Fly   479 IMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVR 543
            |            .:....|.|::  :|....|..|..|:...:|...:..          |...
  Fly   186 I------------NYDSQGGFVVT--SIGQSNPQSGQFYRSSPANKSRATM----------PMES 226

  Fly   544 AIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQG 608
            :.|.:.::.|....:..|.|..|.......:.||.....|    .||:   .|.:|.|. .|..|
  Fly   227 SNGVLNSLLGSSDAIKAPAANVPSSTPYMTQQHQSAYLLN----PSVS---VLTVKQVN-FRHAG 283

  Fly   609 IYTC 612
            .|||
  Fly   284 NYTC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	13/43 (30%)
		Ig	264..334	CDD:143165	13/40 (33%)
		I-set	345..433	CDD:254352	20/94 (21%)
		Ig	358..431	CDD:143165	16/79 (20%)
		Ig	456..533	CDD:143165	15/78 (19%)
		IGc2	553..619	CDD:197706	17/60 (28%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	19/82 (23%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810