DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and VSIG10L2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001352006.1	Gene:	VSIG10L2 / 338667	HGNCID:	27879	Length:	793	Species:	Homo sapiens

Alignment Length:	852	Identity:	171/852 - (20%)
Similarity:	278/852 - (32%)	Gaps:	283/852 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 PRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIP---------------SS 295
            |....:.|:.:...||..|.|.|.  ..|.|:...:..:...:|.|.|               |:
Human    34 PEAPVEEVVSVQGVRGGSVELACG--SGPAPLLVLWSFTPLGSLVPRPVAVTDGAMSKVEAIASA 96

  Fly   296 QRVI-LSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHIL-----PQVQIVNS 354
            ..|: |..:.|::....|...|.::||..:..|.|    ..:..|::::.:|     |||:
Human    97 LGVVSLRNSSLVLGELHEGARGHFLCQVLHVAGGQ----LHAAYSHLTLAVLVPVSKPQVR---- 153

  Fly   355 GGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLV 419
                                |.|..|::..:.:.|                           |.|
Human   154 --------------------LSNPSPVEGASVVAT---------------------------CAV 171

  Fly   420 ENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSL 484
            .                                          .|:.|..|||
Human   172 R------------------------------------------EGTEPVTFAW------------ 182

  Fly   485 HHRFAIGQFVDMSGDV-----ISHLNISHVRPDDGGLYKCVASNSMGSV-QHSARLNV-YGP--P 540
            .||...|....:.|..     :..:|.:|:     |.|.|.||||:..: ...|.|:| |||  |
Human   183 QHRAPRGLGEALVGVTEPLFQLDPVNRTHL-----GWYMCSASNSVNRLSSDGAFLDVIYGPDKP 242

  Fly   541 YVRAIGPIK-------AVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVI 598
            .: .:.|:.       |...|::.:.|..|..|.....|.:.|.::.|...|.:|
Human   243 VI-TMEPLGLTEEGFWASEREEVTLSCLAASNPPSHYVWLRDHTQVHTGPTYVIA---------- 296

  Fly   599 KNVEPGR-DQGIYTCIVR-SRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGD 661
               ..|| ..|:|||:.| |......:..:||.:..||..:|........|.  ..:.||...|.
Human   297 ---RAGRVHTGLYTCLARNSYLDTRTQTTVQLTIYYPPEGQPSCAVHPSPEA--VTLLCAWPGGL 356

  Fly   662 MPIYFSWKKDDS---SIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQ 723
            .|....|:....   :.||::..:....:..|..||           ||...:.|
Human   357 PPAQLQWEGPQGPGPTAPSNVTWSHAAAQLPSGSVF-----------TCTGQHPA---------- 400

  Fly   724 VRVAP-------RWRYEPM------DTAIMLGNTISINCE-AEGYPIPTITWFKGQGKGSKDFKP 774
              :||       .|  ||:      .||.|....|.::|| ..|.|..|:.|...|.      :|
Human   401 --LAPPALCTVMLW--EPLGRPTCWSTATMGDQFIMLSCEWPGGEPPATLGWLDEQQ------QP 455

  Fly   775 LSMRNHSLLLNLATDNDE---GYYMCQATNEIGAGLKKT-----------IRINVNEPARFEQSA 825
            |...:.|:.::|....::   ..:.|:.|:     |.:|           .:::|.||
Human   456 LGGSSSSMAVHLLQAQEDLAGREFTCRGTH-----LLRTPDPHCHLQLEAPQLDVAEP------- 508

  Fly   826 RNISSRRNDPVTLDCHAKGDEP----ITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHS 886
             .:|........|:|..:|..|    :.:|..|.  ::|.....|    |...:|...:|.|..:
Human   509 -RVSVLEGGEAWLECSLRGGTPPAQLLWLGPQQQ--KVDPGTSGF----MLHPEGAQLRLGIYDA 566

  Fly   887 D-RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEV----GSRTVKLSWRRPFDGNSP 946
            | .|..|.|:|:|.|..|.:.|.:.|.|...| .|.::.|..:    ..|.|:|.|.....||
Human   567 DPAHHRGTYQCVARNAVGNSSQSVLLEVLRYP-APPNVTISRLTYGRHRREVQLQWAILGPGN-- 628

  Fly   947 VLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFL 1011
            :..:|||.:|       .:|....|.|.....::. |.:...|           :.||.|...:.
Human   629 LTGFLVQRKA-------SALGPGAGAWETAASDIE-PESRGRR-----------LGGLDPGVLYA 674

  Fly  1012 IRMQAIN 1018
            .|:.|:|
Human   675 FRILALN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	22/106 (21%)
		Ig	264..334	CDD:143165	18/85 (21%)
		I-set	345..433	CDD:254352	10/92 (11%)
		Ig	358..431	CDD:143165	6/72 (8%)
		Ig	456..533	CDD:143165	18/82 (22%)
		IGc2	553..619	CDD:197706	17/67 (25%)
		I-set	634..724	CDD:254352	16/92 (17%)
		ig	645..712	CDD:278476	13/69 (19%)
		IG_like	734..815	CDD:214653	20/101 (20%)
		Ig	745..815	CDD:299845	16/84 (19%)
		I-set	820..913	CDD:254352	23/97 (24%)
		Ig	838..920	CDD:299845	24/86 (28%)
		FN3	917..1033	CDD:238020	24/106 (23%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
VSIG10L2	NP_001352006.1	Ig_3	149..221	CDD:316449	24/181 (13%)
		Ig_3	241..312	CDD:316449	18/84 (21%)
		IG_like	508..594	CDD:214653	24/99 (24%)
		fn3	598..689	CDD:306538	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910