DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and bdl

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_608822.1	Gene:	bdl / 33635	FlyBaseID:	FBgn0028482	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	146/678 - (21%)
Similarity:	239/678 - (35%)	Gaps:	188/678 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GALLLAVLATPLL----ATSGLRVPTFLLEPAPRLLFGNDTGAQVTCTAH-----GSP-PPLVTW 72
            |:.|||:||..||    .||..|      :...:.......|:.|....:     .:| |.||.|
  Fly    13 GSALLALLAIILLMNISCTSAAR------DHRRQTNLEAKVGSHVVFNCYIDFPFDAPIPYLVHW 71

  Fly    73 VLRDGSLATQVPGLRKISG--NGTLHFPPFLAQYYRTDVH--------EATYRCRAS--NEAGTV 125
            ...:..:.|........|.  ||.||......::.|..|:        :..|.|:.|  |.:.:|
  Fly    72 TKDNKKIFTWYEQETSTSELFNGRLHLVENHPEFGRASVNLTAIRESDQGWYHCQVSFPNRSPSV 136

  Fly   126 LSRNVQVHAVVRRQFHVHVE--NTEVYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPDLSDV 188
            .:.....|..|:....:.:.  |..:..|.:|...|.:.   .|....|||:: :.:||.::.|:
  Fly   137 RNNGTAYHLAVQGGSLIRIPPVNQTIREGQTAFFHCVMK---HPENSQASWYK-DGVLLQEVQDL 197

  Fly   189 AGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNL-APRTTQKP 252
            ..|: .:...|.|.:......| |.::.|.|.|: :||.|.:.| .|.::..:|.: ||
  Fly   198 VRRF-YMGPDGSLSIDPTMMSD-LGEYECKVRNS-DGELQTAKA-FLNIQYKAKVIYAP------ 252

  Fly   253 VMEIHVERGNDVHLPCNIQGNPFP-----------IFTWYRVSDSAALYPIPSSQRVILSRTLLL 306
             .|:.:..|....|.|:.:.|| |           :|..|.|  ....|.:..|         |.
  Fly   253 -PEVFLPYGQPAVLDCHFRANP-PLKNLRWEKDGLLFDSYNV--PGVFYKMNGS---------LF 304

  Fly   307 IKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHIL--------PQ-VQIVNSGGTANFNC 362
            ....||..||.:.|...|..|..      ..:..:||.:|        |: :.|...|..|...|
  Fly   305 FAKVDENHAGSYTCTPYNDLGTD------GPSPVISVIVLRPPIFSVTPKAIYIQKLGEAAELPC 363

  Fly   363 TTTGSAID-------AIDW-LHNGKPLQANNALTTGRDNIRF-LSKSSLLVQNVGRRDRGVYQCL 418
                .|||       :|.| ..:|:||.|:          || ||..:|.:..:...|||:|:|.
  Fly   364 ----EAIDRDGNNRPSIIWGRKDGQPLPAD----------RFSLSGGNLTITGLVEGDRGIYECS 414

  Fly   419 VENQRASAQAMAELKLGDTVPELIYTFIEQN-------------VRPGPLISLKCSASGSPPPQF 470
            ..|:.|:..|.|||.:.:..|...|.....:             :||....::......:|..:.
  Fly   415 ATNEAATITAEAELMIENIAPRAPYNLTANSTETCITIRWQPGYLRPNLEYTVWYRLMEAPEWRT 479

  Fly   471 AWLLDSQPIMDVSLHH---------------RFAIGQFV---------------DMSGDVISHLN 505
            ..:||.: :|:.::.|               ::..|.|.               |.....:.| :
  Fly   480 LRVLDKK-VMEATVQHLQPGKEYEFMVLSQDKYGDGMFSKQFRFQTLPSPIRADDFDAQQLQH-D 542

  Fly   506 ISHVRPDDGGL---YKCVA-SNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYP 566
            :..|....|||   :...| ||..|.:.|...             |::.:.|..:..
  Fly   543 LGQVTAPAGGLGAPWNLTAISNQQGWLLHWEH-------------PVQGLEGLRLYA-------- 586

  Fly   567 VEQIRWEK-------AHQELTTSNHYEL 587
               :||.|       .|.| |..|:|:|
  Fly   587 ---VRWWKEPEHFLIGHAE-TFDNYYQL 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	19/94 (20%)
		Ig	56..125	CDD:143165	18/86 (21%)
		I-set	246..337	CDD:254352	21/101 (21%)
		Ig	264..334	CDD:143165	18/80 (23%)
		I-set	345..433	CDD:254352	30/105 (29%)
		Ig	358..431	CDD:143165	24/81 (30%)
		Ig	456..533	CDD:143165	18/110 (16%)
		IGc2	553..619	CDD:197706	10/42 (24%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
bdl	NP_608822.1	IG_like	42..128	CDD:214653	17/85 (20%)
		Ig	43..131	CDD:299845	18/87 (21%)
		I-set	153..242	CDD:254352	24/96 (25%)
		Ig	157..242	CDD:299845	24/92 (26%)
		Ig_2	252..337	CDD:290606	23/109 (21%)
		IG_like	260..327	CDD:214653	19/78 (24%)
		I-set	341..428	CDD:254352	28/100 (28%)
		IGc2	356..419	CDD:197706	23/76 (30%)
		FN3	435..524	CDD:238020	11/89 (12%)
		FN3	554..636	CDD:238020	16/82 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810