DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and itgb4

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio


Alignment Length:1350 Identity:258/1350 - (19%)
Similarity:433/1350 - (32%) Gaps:454/1350 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   516 LYKCVASNSMGSVQHSARL-------NVY-GPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRW 572
            |..|.|...|...:.:..|       |.| ..|.||: ||:|:                .:.:||
Zfish   745 LLPCCARGRMVGFKENQYLLRQSFLQNDYLDTPMVRS-GPLKS----------------TDVVRW 792

  Fly   573 EKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGI-YTCIVR-------------SRAGEEAR 623
            :.|......:||.:            ..:.|...:.| |...:|             :|..:..|
Zfish   793 KVADNVHRGTNHPQ------------NQIRPNPKETIQYPVSLRLNRQFSEVLSNPDARDTDMLR 845

  Fly   624 RDMQLNVNSP----PVIEP-----FKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL 679
            |:::.|:|..    |..:|     |:..:|  .|.|...|...:....|        .||.|..:
Zfish   846 REVEDNLNDVFLQIPGAQPVQKTLFRTQRN--SGKRQNNTIVDTVLSAP--------RSSYPDIV 900

  Fly   680 QITEKKEEFYSLLVFKDISARHSGKYTCYA-SNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGN 743
            ::|:|:.:..:   |:|:.. ..|.||..: ..||..|.:...:          |.:|..:    
Zfish   901 KLTDKQVQSGN---FRDLKV-IPGYYTVASDKEAAGAVEFPENV----------ESVDVRV---- 947

  Fly   744 TISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLK 808
                                          ||.:::.        |:::...:.||. ::..|:.
Zfish   948 ------------------------------PLFIKDE--------DDEKKELLVQAV-DVPVGIA 973

  Fly   809 KTIRINVNEPARFEQSARNIS--------SRR----NDPVTLDCHAKGDEPITIGWTQNNGRIDL 861
            |..:.:||.....||::...:        ||:    |.|:.......|...:|........: |.
Zfish   974 KIGKDHVNITVLKEQASSVFTFLEPSYTYSRQDGVANIPIKRQIIEDGRAQVTYSTADLTAK-DK 1037

  Fly   862 NNF-----RFSIAEMKTEKGVDSQ-LTIGHSD--RHDSGVYRCIAE--NP-----YGRAEQIIFL 911
            .::     ..|....:|||.|..: |.:|..|  ..|..|.:.:.:  ||     .||..:.: :
Zfish  1038 KDYISVDGDLSYGAGETEKIVPVKLLELGEQDGLLEDKQVKQFVMDLTNPRQSAKLGRYPRTV-I 1101

  Fly   912 AVQERPDTPSHLEIFEVGSRT---------------------VKLSWR----RPFDGNSPVLSYL 951
            .:.::|:  |.:..|:..::|                     ..:.||    ..||.:||     
Zfish  1102 TIADKPE--SSVMAFKKSTQTFSTTDSLYTIPVERTGNRETPATVHWRTNKASRFDISSP----- 1159

  Fly   952 VQYQALKYLQSHGSLAAAGGDWNGHVINV-SLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQ 1015
                 ||:        |.|......:||. :.||..|...::.:|        |.|:...:    
Zfish  1160 -----LKF--------APGEAEKNILINPRTHPSPIIPEKFNLEL--------LDPSNNAI---- 1199

  Fly  1016 AINEIERSAYTEAIVL------KTQEEAPTE--------------APSNVQVQTGGESELIVTWQ 1060
                |.:...||.||.      |.|:....|              :|:|::....|...:.:.|:
Zfish  1200 ----IGKRKTTEVIVTDGRGDGKNQDFQKMEYVTQTATSPGGRLYSPANIKAVATGPKNIRLNWK 1260

  Fly  1061 IPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRA 1125
              |.::.||..:.|.: ..:.:....|:.|             .|.:|.|..|..|..|.:.:..
Zfish  1261 --PSQNANGYKVKYWI-YGDPEDKAKFMDV-------------KTPQAELTNLDPYCDYEMRVCG 1309

  Fly  1126 MNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPI 1190
            .|:.|.|.:|..|...|.|.:| ..|..:....:|....::||.||...  .|||.||:::|.||
Zfish  1310 YNALGDGNYSDIIQCQTLEDIP-GEPGRLAFNVISPTVTQVSWAEPAEA--NGIITGYEVIYMPI 1371

  Fly  1191 VHQ---IDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDG--------LASHPLFCQT 1244
            ...   ...|.|:.|.........:..|..:..|..:|.|....|.|        |||.|....:
Zfish  1372 NEDKKPTGPPKKVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVGWGPYREATINLASQPTRPMS 1436

  Fly  1245 DDDVPDAPAAIKAAALTADSILI--------------------------------SWLTPKNRNG 1277
            ...:||.|.....|....||.|:                                ::|.|....|
Zfish  1437 IPIIPDIPIVDAEAGEEYDSYLMYSNEVLRSPTSSLRPSVTDLSDDQFVNGKWEQNFLFPGGGGG 1501

  Fly  1278 -----IISHYTVYSREAGR---------------KGQAKTHMVRVDENGY---PVTFESRSLAEN 1319
                 |.|..|.||....|               ||.:.||...|.:.|.   .|....||  ||
Zfish  1502 SLSRNISSSSTTYSHSTPRTNVTNNSSTTTYISGKGGSTTHRYDVRDGGLLKEDVILRKRS--EN 1564

  Fly  1320 QMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARW 1384
            :.|        :.|:|...|::              .|.:      :|.:|:.|.|         
Zfish  1565 RHY--------TEGDGVRDSIV--------------MGNL------SGGLLDNLGV--------- 1592

  Fly  1385 LTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMK---------- 1439
                     |.|.:.|              |.:|:.::.....|::|...::.:.          
Zfish  1593 ---------SSFSQTT--------------STSYSLSSRARTQSEDINDALLNLDSVLQESRFTP 1634

  Fly  1440 --PPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYH--TAGESWSITELLPENNAFTISG 1500
              |.:..:::.......:::|||..|......| ||.:.|.  ..|:...|....|..|:..:..
Zfish  1635 GVPATPSRLVFSALGHTALKVSWQEPHCESDVL-GYCVLYQLINGGDVKRIEVNNPAQNSVLVQD 1698

  Fly  1501 LKCGNQYIIKMSAHNMVG-----SGVASEEINVWTKGKASQAPNA----------NELIATNATC 1550
            |.....||.|:.|.:..|     .||.:.|.||..|...|..|.:          ..||.|....
Zfish  1699 LLPNQSYIFKVKAQSREGWGPEREGVITIESNVDPKSPLSPVPGSPFTLSTPSAPGPLIFTALRP 1763

  Fly  1551 VNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVT-------SDISNAEEN---RENLIFCDFLPA 1605
            ..|:| ||:.          ..:|.|||...|||       .|:.:.:.|   ..:|...|....
Zfish  1764 DTLQL-SWEK----------PRKPNGDILGYVVTCEQLHGGGDLRSFQVNGNAATSLTVSDLKEN 1817

  Fly  1606 KWYQLRISA-----------------TNDAGKTTEHYHFSTTNIDGITIP 1638
            ..|:.::.|                 :.|.|..:::...|.|..:...:|
Zfish  1818 MPYKFKVQAQTTQGFGPEREGIITIESQDGGSMSQYSSQSVTKREVFNLP 1867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352
Ig 358..431 CDD:143165
Ig 456..533 CDD:143165 4/16 (25%)
IGc2 553..619 CDD:197706 10/79 (13%)
I-set 634..724 CDD:254352 21/95 (22%)
ig 645..712 CDD:278476 14/67 (21%)
IG_like 734..815 CDD:214653 8/80 (10%)
Ig 745..815 CDD:299845 7/69 (10%)
I-set 820..913 CDD:254352 23/119 (19%)
Ig 838..920 CDD:299845 18/96 (19%)
FN3 917..1033 CDD:238020 27/147 (18%)
FN3 1040..1142 CDD:238020 22/115 (19%)
fn3 1150..1237 CDD:278470 24/97 (25%)
FN3 1263..1345 CDD:238020 27/136 (20%)
Ig 1350..1436 CDD:299845 12/85 (14%)
IG_like 1358..1436 CDD:214653 11/77 (14%)
FN3 1441..1530 CDD:238020 23/95 (24%)
FN3 1542..1620 CDD:238020 21/104 (20%)
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776
EGF_2 <468..490 CDD:285248
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239
Calx-beta 991..1064 CDD:295344 12/73 (16%)
FN3 1242..1326 CDD:238020 21/99 (21%)
FN3 1331..1420 CDD:238020 24/91 (26%)
fn3 1640..1720 CDD:278470 18/80 (23%)
fn3 1751..1835 CDD:278470 20/94 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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