DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and side-II

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	1100	Identity:	222/1100 - (20%)
Similarity:	355/1100 - (32%)	Gaps:	301/1100 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 SGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNI------------------------ 394
            |||.::.:.......|||::    ||.:.....:|...||:
  Fly    42 SGGISSKDSHVKTKDIDAVE----GKSVSLPCPITEPLDNVYMVLWFRDNAGIPLYSFDVRDKES 102

  Fly   395 -----------------RFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELI 442
                             :|...|......:.|.|:|:|:|.|:.:.:..|:. ...|.      :
  Fly   103 REQPRHWSAPEVFGSRAKFHFDSQPATLEIKRHDQGIYRCRVDFRTSQTQSF-RFNLS------V 160

  Fly   443 YTFIEQNV-----------------RPGPLISLKCS-ASGSPPPQFAWLLDSQPIMDVSLHHRFA 489
            ....||.:                 :.|..|.:.|. ..|.|.||..||::...:.:.:.|:
  Fly   161 IILPEQPIIMDRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEHN--- 222

  Fly   490 IGQFVDMSGDVISH--LNISHVRPDDGGLYKCVASNSM--GSVQHSARLNVYGPPYVRAI--GPI 548
                   |||||.:  |..|..|.|...::.|.|.|:.  ...:.|..|:::..|.|..|  .|.
  Fly   223 -------SGDVIENRLLWPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPS 280

  Fly   549 KAVAGEDIIVHCPFAG-YPVEQIRWEKAHQEL--------TTSNHYELASVA---DGGQLVIKNV 601
            ..:|.....|.|..:| .|...|.|.|..::|        ..|...||:.|.   |.|:.:....
  Fly   281 SMIADRRYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISKNSTRSELSFVPTTDDDGKSITCRA 345

  Fly   602 EPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIE----PFKFPKNLQEGGRAQITCAVSSGDM 662
            |.....|:|           .....:|||..||::.    ....|.:::||......|.|.|...
  Fly   346 ENPNVNGLY-----------LETMWKLNVVYPPLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQ 399

  Fly   663 PIYFSWKKDDSSIP--SSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVR 725
            .....|..:...:.  :|.::....:.    ||.:.|:..::|.|.|.|.|...: ..:.:|.:|
  Fly   400 WRKLLWLHNGIHLEHNTSARVIRSNQS----LVLQKITKHYAGNYACSAINDEGE-TVSNQLPLR 459

  Fly   726 VAPRWRYEPM----DTAIMLG----NTISINCEAEGYPIP-TITW-FKGQGK----GSKDFKPLS 776
            |    :|.||    |..|::|    .|:.:.||.:..|.| |..| |...|:    ||:.|....
  Fly   460 V----KYTPMCKHADRVILIGASKDETVEVVCEIQADPPPRTFRWKFNNSGETLDVGSERFSVNG 520

  Fly   777 MRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFE---------QSARNISSRR 832
            .|: .|.....||.|.|...|.|:||:|         ....|..|:         .|...:.:|.
  Fly   521 SRS-ILKYTPVTDQDYGTLSCWASNEVG---------TQQHPCLFQVVLAALPNAVSNCTVFNRT 575

  Fly   833 NDPVTLDC--HAKGDEPITIGWTQNNGRIDLNNFRFSIAE--MKTEKGVDSQLTIGHSDRHDSGV 893
            ...|.:.|  ...|..|........:.|..:..|..|.||  :.:.:.:|: ||......::|..
  Fly   576 ELSVDIQCIPGYDGGLPQIFVLEMFSTRTGITRFNLSNAEEALFSLENLDT-LTSMMVQENNSLR 639

  Fly   894 YRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGN-----SPVL----- 948
            .|..:.|..||:...:             |..|.:||...|.      |.:     |||:
  Fly   640 LRIYSYNQKGRSAAYL-------------LTDFIIGSTAYKT------DDDVTLTLSPVIVGSVL 685

  Fly   949 ------------SYLVQY-QALKYLQSHGSLAAAGG-----------------DWNGHVINVSLP 983
                        .::|.: ..|:..:.|||.|.|.|                 .|....|.....
  Fly   686 TIIIIGVAIAIRIFVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPRWQHTDIKTKSS 750

  Fly   984 STSISRSYDSDLRESAIV----AGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEA--- 1041
            ...:....|.|:..|..|    ||.:.:....:..........|:.:.|:|......|...|
  Fly   751 EDLVEDERDPDVIPSQYVGGSSAGSSGSNASNVGSTTAGTATGSSTSTAVVANANAAASAMAGPG 815

  Fly  1042 --------------PSNVQVQTGGESELIVTWQIPPRESWNGE-----LIGYTVNCSEEKQNIN- 1086
                          .|......||.|:    |      |.||.     |.|..||.:.....||
  Fly   816 GATSSASATDGHQFASGTAAAGGGASK----W------SPNGNVTTTMLTGDAVNATVTYNQINA 870

  Fly  1087 -------FISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAE 1144
                   .::.|.....||::|   .:.:.|.||.|            ..|.|....  .|....
  Fly   871 QRAQLLAAVAAVGGGCSSTVIS---PSSSILGGLGK------------PLGMGMGMG--LGMGVG 918

  Fly  1145 GVPEAAPQNVNCTALSSQSLK------ISWLEPPLQFHGG-IIQGYKI--LYRP----IVHQIDF 1196
            |....:|.:::.||..:..|:      :..|.|.|...|| |:..|..  |:.|    :......
  Fly   919 GTVIGSPTSLSSTATLAAHLQPAHSSGVGTLPPGLGSGGGYILNAYASGRLHHPPGGGVPGGATH 983

  Fly  1197 PAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGD------GLASHPLFCQTDDDVPD 1250
            .|.|........:.:.|..|:..::|...|...:.|.      ...:....|.:..|:.|
  Fly   984 TATLNRHHHQQQQLHHHPHHQQPHHSGSSLLMGSAGSVMGVVGSTTTATTSCNSSQDLDD 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	20/119 (17%)
		Ig	358..431	CDD:143165	17/113 (15%)
		Ig	456..533	CDD:143165	22/81 (27%)
		IGc2	553..619	CDD:197706	17/77 (22%)
		I-set	634..724	CDD:254352	18/95 (19%)
		ig	645..712	CDD:278476	14/68 (21%)
		IG_like	734..815	CDD:214653	28/94 (30%)
		Ig	745..815	CDD:299845	22/75 (29%)
		I-set	820..913	CDD:254352	20/105 (19%)
		Ig	838..920	CDD:299845	16/85 (19%)
		FN3	917..1033	CDD:238020	28/159 (18%)
		FN3	1040..1142	CDD:238020	26/131 (20%)
		fn3	1150..1237	CDD:278470	20/105 (19%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	18/115 (16%)
		Ig	57..160	CDD:299845	18/113 (16%)
		Ig	188..251	CDD:299845	21/72 (29%)
		Ig	289..363	CDD:299845	18/84 (21%)
		IG_like	289..351	CDD:214653	15/61 (25%)
		Ig_2	376..460	CDD:290606	17/88 (19%)
		IG_like	383..454	CDD:214653	15/75 (20%)
		Ig	470..548	CDD:299845	26/87 (30%)
		IG_like	481..557	CDD:214653	25/85 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910