DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and HSPG2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_011539620.1	Gene:	HSPG2 / 3339	HGNCID:	5273	Length:	4574	Species:	Homo sapiens

Alignment Length:	2516	Identity:	523/2516 - (20%)
Similarity:	809/2516 - (32%)	Gaps:	772/2516 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ATSGLRVPTFLLEPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTL 95
            |:..|..|...:.| |:|.......|:..|:|.|||.|.:.|.   |....|:|...:|.| |.|
Human  2042 ASGTLSAPVVSIHP-PQLTVQPGQLAEFRCSATGSPTPTLEWT---GGPGGQLPAKAQIHG-GIL 2101

  Fly    96 HFP---PFLAQYYRTDVHEATYRCRASNEAGTVLSRNV-QVHAVVRRQFHVHVENTEVYLGNSAL 156
            ..|   |       ||  :|.|.|||.:.||..::|.| .||.....:..|..|.|:|:.|.:
Human  2102 RLPAVEP-------TD--QAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRT-- 2155

  Fly   157 IKCAIPEYVRPYVRVA-------SWHRGEEILLP----DLSDVAGRYVVLAASGDLYVRSVRSED 210
                    ||.|.|.|       :|.:....|.|    :.:|:|          .|.:.::.:.|
Human  2156 --------VRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----------TLLIPAITTAD 2202

  Fly   211 GLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPF 275
            ... :.|:.|:.....:.|...|:|...:.|.......:..|    .|..|..:.|.|.:.|:..
Human  2203 AGF-YLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSP----SVTEGQTLDLNCVVAGSAH 2262

  Fly   276 PIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSV--- 337
            ...||||...|     :|...:|..||  |.:......|:|:::|:..|..|.:...|.:||
Human  2263 AQVTWYRRGGS-----LPPHTQVHGSR--LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2320

  Fly   338 ----NSYVSV-------HILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGR 391
                .||..|       .|.|....|..|.|.:.||...|.|...:.|...|..|.|.:. |.|
Human  2321 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQ-THG- 2383

  Fly   392 DNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPL- 455
                    |.|.:..|...|.|.|.|.|.......:|.            :...||.:|.|||:
Human  2384 --------SLLRLHQVTPADSGEYVCHVVGTSGPLEAS------------VLVTIEASVIPGPIP 2428

  Fly   456 ----------------ISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHL 504
                            :.|.|..:|....|..|.....     ||..|..:..         |.|
Human  2429 PVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGG-----SLPARHQVRG---------SRL 2479

  Fly   505 NISHVRPDDGGLYKCVASNSM--------------------GSVQ-------------------- 529
            .|....|.|.|.|.|.|||.|                    ||.|
Human  2480 YIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLN 2544

  Fly   530 --------------------------HSARLNVY-------GPPYVRAIG---PIKA-------- 550
                                      |.:.|.:|       |....|.:|   |::|
Human  2545 CVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEP 2609

  Fly   551 ----------------------VAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADG 593
                                  ..|:.:.::|..||....|:.|.|....|...:.      ..|
Human  2610 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQ------VHG 2668

  Fly   594 GQLVIKNVEPGRDQGIYTC-IVRSRAGEEAR-----RDMQLNVNSPPVIEPFKFPK---NLQEGG 649
            .:|.:..|.|. |.|.|.| :|.|...:||.     :......:|..|..|.:...   :|..|.
Human  2669 SRLRLLQVTPA-DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGH 2732

  Fly   650 RAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAA 714
            ...:.|.|:| ..|...:|.|...|:||..||..      |.|....::...||:|.|:.||.|.
Human  2733 TLDLNCLVAS-QAPHTITWYKRGGSLPSRHQIVG------SRLRIPQVTPADSGEYVCHVSNGAG 2790

  Fly   715 KVNYTAELQVR---------VAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSK 770
            ....:..:.::         |:|..|.|.....::.|.|:.:||.....|...|||:|..|.
Human  2791 SRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS--- 2852

  Fly   771 DFKPLSMRNHS--LLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE------------PARF 821
              .|...:.|.  |.|:..:..|.|.|:|:|.|.|.| |:.:|.|:|:.            |.|.
Human  2853 --LPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA-LEASIVISVSPSAGSPSAPGSSMPIRI 2914

  Fly   822 EQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHS 886
            |.|:.:::  ..:.:.|:|...|.....:.|.:..|         |:......:|  |:|.:.|.
Human  2915 ESSSSHVA--EGETLDLNCVVPGQAHAQVTWHKRGG---------SLPSHHQTRG--SRLRLHHV 2966

  Fly   887 DRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKL--SWRRPFDGNSPVLS 949
            ...|||.|.|......|..|..:.:.::....:..|:.. ..|:..:::  |..|..:|.:..|.
Human  2967 SPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPA-PGGAPPIRIEPSSSRVAEGQTLDLK 3030

  Fly   950 YLVQYQALKYLQSH--GSLAAAGGDWNGHVINVSLPSTSISRSY------DSDLRESAIVAGLTP 1006
            .:|..||...:..|  |....|....:|.::.::..|.:.|..|      .|...|::::..:.|
Human  3031 CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 3095

  Fly  1007 ATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPS-NVQVQTGGESELIVTW-----QIPPRE 1065
            ::.        ..|......:.|.::......||..: ::.....|::...|||     .:|.|.
Human  3096 SSP--------GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARH 3152

  Fly  1066 SWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFG 1130
            ..:|                       |.|:..:||...:.:...|.               :.|
Human  3153 QTHG-----------------------SQLRLHLVSPADSGEYVCRA---------------ASG 3179

  Fly  1131 SGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQID 1195
            .||...|.|..|   ||   |...:...|.|..:.|   :||   ...:.||....::.::|...
Human  3180 PGPEQEASFTVT---VP---PSEGSSYRLRSPVISI---DPP---SSTVQQGQDASFKCLIHDGA 3232

  Fly  1196 FPAKLEIK-RTSNLETYLHTLHKASNYSI-----------RVLAYTATG-----DGLASH-PLFC 1242
            .|..||.| |...||..:|.....|..:|           |.:|..|.|     ..|:.| |
Human  3233 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP--- 3294

  Fly  1243 QTDDDVPDAPAAIKAA-ALTADSILIS-------WL----TP----KNRNGIISHYTVYSREAGR 1291
            .|...:|:.|..:|.. |:|.:.:...       |.    ||    :...|::..:.|....:.:
Human  3295 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3359

  Fly  1292 KGQAKTHM---------------VRVD--------------------ENGY-------------- 1307
            ...|.|::               |.||                    |.|:
Human  3360 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAP 3424

  Fly  1308 ---------PVTFESR---------SLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIA 1354
                     |:.::.|         .:|:....::..:|::..|..|.|.::    :..:|....
Human  3425 TIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIIL----HVESPPYAT 3485

  Fly  1355 SFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLSGNYT 1419
            :..:......|..:.|:|||.|.|....:|   .|..:..|.........|...|.....||.|.
Human  3486 TVPEHASVQAGETVQLQCLAHGTPPLTFQW---SRVGSSLPGRATARNELLHFERAAPEDSGRYR 3547

  Fly  1420 CTANNLFGSDEIQYQVIAMKPP-SAPQIIVQYASADSIRVSWDAPDDGGAPLQ----GYTISYHT 1479
            |...|..||.|...|::...|| |.|...:...|..:::|:        ..|:    |.::.:|.
Human  3548 CRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVT--------PQLETKSIGASVEFHC 3604

  Fly  1480 AGESWSITEL--------LP-----ENNAFTISGL--KCGNQYIIKMSAHNMVGSGVASEEINVW 1529
            |..|...|:|        ||     ::....|..|  .|...||.:  ||...|...||.::.:
Human  3605 AVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQ--AHGPWGKAQASAQLVI- 3666

  Fly  1530 TKGKASQA-PNANELIATNATCVNLKLSSWQNGGCSIHHFSIEHRPLGD----IRWTVVTSDISN 1589
                  || |:....|.|:...|.:.           |....|...|||    :.|:.|...:..
Human  3667 ------QALPSVLINIRTSVQTVVVG-----------HAVEFECLALGDPKPQVTWSKVGGHLRP 3714

  Fly  1590 AEENRENLIFCDFLP-AKWYQLRISATNDAGKTTEHY---------------------------- 1625
            .......::....:. |...|.|.:|||.||.|..|.
Human  3715 GIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPC 3779

  Fly  1626 --------HFSTTNIDGITIPPPSVFPSENDLMNNLINSTNP-TSGDWFATLI------------ 1669
                    ..|.:.:|| ::||.|..  ||:::  ::.|..| .:|.:..|..
Human  3780 IASGYPTPDISWSKLDG-SLPPDSRL--ENNML--MLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3839

  Fly  1670 -----VVVIIT---VSIITIALTIKHRRTLCGPIAEGYESRTLPGDYKEDHEN----RRNQQVYS 1722
                 ||...|   .|.:.:. |||          :.|....:...::.|..:    ...|:...
Human  3840 QVPERVVPYFTQTPYSFLPLP-TIK----------DAYRKFEIKITFRPDSADGMLLYNGQKRVP 3893

  Fly  1723 ASPVKTVDKGNESEMYEISPYATFSVNGGR--------TG-APAKTPT----------------- 1761
            .||....::..:        :.:|.:.|||        :| |..:.||
Human  3894 GSPTNLANRQPD--------FISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLT 3950

  Fly  1762 ---RAVAAQTPLDYTMQFKTFGHPEGENLNATAYP---LLP----SSGF-GHVKSKSSWHKQRYY 1815
               ..|....|::.|.|.|..|....|.|....||   .:|    |||| |.|         |..
Human  3951 QGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCV---------REL 4006

  Fly  1816 NTEDESTLSKSMTIVAGSQAGHSKK------SNGGRSAKSSAA-----CSGVVAGSESDTS---- 1865
            ..:.|..:...:.:.|.. ..|...      .|||:...|.::     |.....||..:.|
Human  4007 RIQGEEIVFHDLNLTAHG-ISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALH 4070

  Fly  1866 -----ISPSTEFSNMPT---YRVPCKSSRS----SDGRAVVDMFRPDSSTESNNDQGS----PAP 1914
                 ..|.....|.|.   |...|...||    .:|..|        :|.|.:..||    ||.
Human  4071 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTV--------TTPSLSGAGSYLALPAL 4127

  Fly  1915 ERRHNTPRHVLGM----------GMAMGLGGGGG--------GGVGG--------GNGPAEKRSA 1953
            ...|    |.|.:          |:.:..||..|        ..|||        |:|.|..|||
Human  4128 TNTH----HELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSA 4188

  Fly  1954 ------------GQRSRKHGSAAQQPSNQTLERRKCPGSSNSL-----------DSEVDAETAAS 1995
                        .:|..|.||.........|  |..||.|..|           :..|....|.:
Human  4189 EPLALGRWHRVSAERLNKDGSLRVNGGRPVL--RSSPGKSQGLNLHTLLYLGGVEPSVPLSPATN 4251

  Fly  1996 LAASIAAMAG----SGAGADLSGGFRPPAGFHDGREPGDHSDCERE 2037
            ::|......|    :|...||:..|....|.   .:..|.|.|||:
Human  4252 MSAHFRGCVGEVSVNGKRLDLTYSFLGSQGI---GQCYDSSPCERQ 4294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	28/80 (35%)
		Ig	56..125	CDD:143165	26/71 (37%)
		I-set	246..337	CDD:254352	22/90 (24%)
		Ig	264..334	CDD:143165	18/69 (26%)
		I-set	345..433	CDD:254352	24/87 (28%)
		Ig	358..431	CDD:143165	19/72 (26%)
		Ig	456..533	CDD:143165	24/142 (17%)
		IGc2	553..619	CDD:197706	18/66 (27%)
		I-set	634..724	CDD:254352	24/92 (26%)
		ig	645..712	CDD:278476	20/66 (30%)
		IG_like	734..815	CDD:214653	25/82 (30%)
		Ig	745..815	CDD:299845	23/71 (32%)
		I-set	820..913	CDD:254352	20/92 (22%)
		Ig	838..920	CDD:299845	17/81 (21%)
		FN3	917..1033	CDD:238020	21/125 (17%)
		FN3	1040..1142	CDD:238020	18/107 (17%)
		fn3	1150..1237	CDD:278470	24/103 (23%)
		FN3	1263..1345	CDD:238020	19/163 (12%)
		Ig	1350..1436	CDD:299845	22/85 (26%)
		IG_like	1358..1436	CDD:214653	21/77 (27%)
		FN3	1441..1530	CDD:238020	24/108 (22%)
		FN3	1542..1620	CDD:238020	17/82 (21%)
HSPG2	XP_011539620.1	SEA	80..193	CDD:214554
		LDLa	216..251	CDD:238060
		LDLa	302..336	CDD:238060
		LDLa	342..376	CDD:238060
		LDLa	385..420	CDD:238060
		IG	431..507	CDD:214652
		Ig_Perlecan_D2_like	438..515	CDD:143220
		LamB	608..734	CDD:214597
		EGF_Lam	782..824	CDD:238012
		EGF_Lam	831..888	CDD:238012
		Laminin_EGF	897..939	CDD:278482
		LamB	1003..1130	CDD:214597
		EGF_Lam	1176..1225	CDD:238012
		EGF_Lam	1227..1282	CDD:238012
		Laminin_EGF	1293..1340	CDD:278482
		LamB	1574..1699	CDD:214597
		EGF_Lam	1746..1794	CDD:238012
		Laminin_EGF	1796..1851	CDD:278482
		Ig_2	1866..1958	CDD:290606
		IG_like	1866..1946	CDD:214653
		Ig3_Perlecan_like	1954..2039	CDD:143231
		IG	1961..2040	CDD:214652
		I-set	2049..2133	CDD:254352	32/97 (33%)
		Ig	2063..2133	CDD:299845	28/82 (34%)
		I-set	2139..2225	CDD:254352	20/106 (19%)
		IGc2	2153..2215	CDD:197706	15/82 (18%)
		IG_like	2240..2317	CDD:214653	22/87 (25%)
		IGc2	2247..2307	CDD:197706	18/66 (27%)
		IG	2341..2418	CDD:214652	23/98 (23%)
		IGc2	2348..2408	CDD:197706	20/69 (29%)
		IG_like	2434..2508	CDD:214653	20/87 (23%)
		IGc2	2441..2500	CDD:197706	19/72 (26%)
		IG_like	2530..2607	CDD:214653	8/76 (11%)
		IGc2	2537..2595	CDD:197706	5/57 (9%)
		I-set	2620..2703	CDD:254352	20/89 (22%)
		IGc2	2633..2693	CDD:197706	18/66 (27%)
		IG	2731..2800	CDD:214652	21/75 (28%)
		IGc2	2731..2790	CDD:197706	20/65 (31%)
		IG_like	2819..2896	CDD:214653	25/82 (30%)
		IGc2	2826..2885	CDD:197706	20/63 (32%)
		IG	2916..2993	CDD:214652	18/89 (20%)
		IGc2	2923..2983	CDD:197706	15/70 (21%)
		IG	3016..3093	CDD:214652	16/76 (21%)
		IGc2	3023..3083	CDD:197706	12/59 (20%)
		Ig_2	3112..3192	CDD:290606	20/120 (17%)
		IG_like	3115..3192	CDD:214653	20/117 (17%)
		I-set	3205..3291	CDD:254352	21/91 (23%)
		ig	3209..3289	CDD:278476	20/85 (24%)
		IG	3303..3385	CDD:214652	12/81 (15%)
		Ig	3313..3382	CDD:143165	8/68 (12%)
		IG	3404..3478	CDD:214652	9/77 (12%)
		IGc2	3409..3468	CDD:197706	5/58 (9%)
		I-set	3482..3565	CDD:254352	21/85 (25%)
		IGc2	3496..3555	CDD:197706	17/61 (28%)
		IG_like	3589..3666	CDD:214653	19/78 (24%)
		Ig	3600..3666	CDD:299845	17/67 (25%)
		I-set	3676..3755	CDD:254352	20/89 (22%)
		IGc2	3686..3745	CDD:197706	13/69 (19%)
		I-set	3764..3841	CDD:254352	12/81 (15%)
		Ig	3779..3834	CDD:299845	12/59 (20%)
		LamG	3848..4008	CDD:238058	36/187 (19%)
		EGF_CA	<4035..4064	CDD:238011	7/28 (25%)
		LamG	4117..4266	CDD:238058	34/154 (22%)
		EGF	4291..4321	CDD:278437	3/4 (75%)
EGF_CA	4328..4359	CDD:238011
LamG	4386..4545	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910