DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and robo3

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_608592.2 Gene:robo3 / 33314 FlyBaseID:FBgn0041097 Length:1342 Species:Drosophila melanogaster


Alignment Length:1748 Identity:339/1748 - (19%)
Similarity:549/1748 - (31%) Gaps:555/1748 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 PRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSR----TLLL 306
            ||..:.|: :..|.|.....|.|..:|:|.|...||:  |...|..:|.|.|:.|..    .|.:
  Fly    23 PRIVEHPI-DTTVPRHEPATLNCKAEGSPTPTIQWYK--DGVPLKILPGSHRITLPAGGLFFLKV 84

  Fly   307 IKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHIL-------PQVQIVNSGGTANFNCTT 364
            :.:..|.|||.:.|:|.|:.|..|     |.|:.:.|.:|       ||...:..|.||...|..
  Fly    85 VNSRRETDAGIYWCEAKNELGVAR-----SRNATLQVAVLRDEFRLEPQNTRIAQGDTALLECAA 144

  Fly   365 -TGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQ---RAS 425
             .|.....:.|...|:.|...     |...:|.:...:|.:|:..:.|.|.|||:.:|.   |.|
  Fly   145 PRGIPEPTVTWKKGGQKLDLE-----GSKRVRIVDGGNLAIQDARQTDEGQYQCIAKNPVGVRES 204

  Fly   426 AQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAI 490
              ::|.||: ...|.:|....:|.|..|..::..|...|.|.|...||             |.|.
  Fly   205 --SLATLKV-HVKPYIIRGPHDQTVLEGASVTFPCRVGGDPMPDVLWL-------------RTAS 253

  Fly   491 GQFVDMSGDVIS-----HLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPP-YVRAIGPIK 549
            |.  :|..|.:|     .|.:..|...|.|.|.|.|.|.:|::.....|.||.|| :::......
  Fly   254 GG--NMPLDRVSVLEDRSLRLERVTIADEGEYSCEADNVVGAITAMGTLTVYAPPKFIQRPASKS 316

  Fly   550 AVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIV 614
            ...|.|....|...|.|...|.|       |..|:..|             :.||          
  Fly   317 VELGADTSFECRAIGNPKPTIFW-------TIKNNSTL-------------IFPG---------- 351

  Fly   615 RSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL 679
                             :|| ::.| ...|.:||                           .|.|
  Fly   352 -----------------APP-LDRF-HSLNTEEG---------------------------HSIL 370

  Fly   680 QITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQV-----RVAPRWRYEPMDTAI 739
            .:|..:.....|::.            |.|.|..|.:....:|.:     |..|.....|::..:
  Fly   371 TLTRFQRTDKDLVIL------------CNAMNEVASITSRVQLSLDSQEDRPPPIIISGPVNQTL 423

  Fly   740 MLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHS-----LLLNLATDNDEGYYMCQA 799
            .:.:..::.|:|.|.|.|||:|:    :.....:|.|..|.:     ::.:|....|:|.|.|.|
  Fly   424 PIKSLATLQCKAIGLPSPTISWY----RDGIPVQPSSKLNITTSGDLIISDLDRQQDQGLYTCVA 484

  Fly   800 TNEIGAGLKKT------IRINVNEPARFEQSARNIS--SRRNDPVTLDCHAKGDEPITIGWTQNN 856
            ::..|   |.|      |.:..|...:|.::.....  |....|..|:..|..   :||.|..  
  Fly   485 SSRAG---KSTWSGFLRIELPTNPNIKFYRAPEQTKCPSAPGQPKILNATASA---LTIVWPT-- 541

  Fly   857 GRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPS 921
                                         ||:..:..:...:...|...:...::.:..|...| 
  Fly   542 -----------------------------SDKAGASSFLGYSVEMYCTNQSRTWIPIASRLSEP- 576

  Fly   922 HLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYL---QSHGSLAAAGGDWNGHVINVSLP 983
               ||.|.|.|                      |...|:   ::..||..:             |
  Fly   577 ---IFTVESLT----------------------QGAAYMFIVRAENSLGFS-------------P 603

  Fly   984 STSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQ 1048
            .:.||         ..|.||         ::..:.:...|..|..::| :..|...:|...|::.
  Fly   604 PSPIS---------EPITAG---------KLVGVRDGSESTGTSQLLL-SDVETLLQANDVVELL 649

  Fly  1049 TGGESELIVTWQIPPRESW---NGELI-GYTVNCSE-EKQNINFISVVNSSLKSTIVSGWATTKA 1108
            ....|:     ....|.||   :|:.| |:.:...| .......::::|        .|...:..
  Fly   650 EANASD-----STTARLSWDIDSGQYIEGFYLYARELHSSEYKMVTLLN--------KGQGLSSC 701

  Fly  1109 TLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFG--------TTAEGVPEAAPQNVNCTALSSQSLK 1165
            |:.||.|.|.|        .|...|:..:|.|        .|.|.||||.|..:.....:..|:.
  Fly   702 TVPGLAKASTY--------EFFLVPFYKSIVGKPSNSRRMRTLEDVPEAPPYGMEAIQFNRTSVF 758

  Fly  1166 ISWLEP-PLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKAS-----NYSIR 1224
            :.||.| |.:...||:..|.:    :|..:|......|.:...::....||..|:     .|.|.
  Fly   759 LKWLPPQPNRTRNGILTSYNV----VVKGLDVHNTTRIFKNMTIDAAAPTLLLANLTTGVTYYIA 819

  Fly  1225 VLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREA 1289
            |.|.|..|.|..|.|...:.|                                            
  Fly   820 VAAATRVGVGPFSKPAVLRID-------------------------------------------- 840

  Fly  1290 GRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSA-------------------------- 1328
                 |:|..:......||:   ||.:|::.:.:.|...                          
  Fly   841 -----ARTQSLDTGYTRYPI---SRDIADDFLTQTWFIVLLGSIIAIIVFLLGALVLFKRYQFIK 897

  Fly  1329 STSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTF 1393
            .||:|.......|  .|..:.|....:.|    .|||.|......|.|. :....|:    ..|.
  Fly   898 QTSLGSLHGNHAI--GTVRKFPTLPLNGG----GAVGAGGSNSTAAAGQ-SGHGLWI----DPTS 951

  Fly  1394 SPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRV 1458
            ..:.:....||         ..|..:||.......    |.....:....|.::..|.....:.:
  Fly   952 GVWRQAAGGGN---------PGGVGSCTTKEQLPG----YAQATAQQGQQPTLLPDYERLSPLNM 1003

  Fly  1459 ---------SWDAPDDGGAPLQGYTISYHTAGESWSITELLPENNAFTISGLKCGNQYIIKMSAH 1514
                     ::.:|..|..|:.|     ...|:|.|:.:             .||     ..:..
  Fly  1004 PDYAEVACSTFKSPTHGAPPMGG-----GGGGQSASLYD-------------SCG-----AYATT 1045

  Fly  1515 NMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGC-----SIHHFSIEHRP 1574
            |:| :.|...:....||...|...|.|          |.:.:.:|:.|.     |.|:..:|.: 
  Fly  1046 NVV-ANVKLYQNRYATKPNQSSGSNNN----------NHQGNDYQSTGMYSAPPSAHYGCLEPK- 1098

  Fly  1575 LGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPP 1639
                         ...::.:.||:                      ||     ||.:...:|..|
  Fly  1099 -------------QQQQQQQPNLM----------------------TT-----STASTAILTNSP 1123

  Fly  1640 PSVFP---SEN--DLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGY 1699
            ..|..   :||  |.:......|||.:..      ..:::..:.:...|......||...:|.|.
  Fly  1124 AKVKKINITENKMDQLEGKSERTNPFNQQ------QQLLLASNALKQGLGAYANTTLAAQMASGG 1182

  Fly  1700 ESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPYATFSVNGGRTGAPAKTPTRAV 1764
            .:.||          ||.:|      .||:.|...:.:             |::|....|...:|
  Fly  1183 GAGTL----------RRQRQ------PKTLYKSENNIL-------------GKSGLRQNTMNASV 1218

  Fly  1765 AAQTPLDYTMQFKTFGHP-EGENL------NATAYPL--------LPSSGFGHVKSKSSWHKQRY 1814
            .|  |.:..|.|.|.|.| ||.:.      |:|...|        :.:.|..|..||....:..|
  Fly  1219 GA--PSNGQMDFLTGGPPSEGGDFSGLGLCNSTNQLLNDWASSASIAAPGDYHFGSKQPSKQHLY 1281

  Fly  1815 YNTED---ESTLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPS 1869
            ...:|   .:..|.:.......|..|...:..|.:.||.|:.:.:...|:..:|...|
  Fly  1282 VKAKDGTWSAVSSDAYQSFKHQQQHHPFLAGSGDNTKSLASVNSLAGDSKFLSSFGSS 1339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 28/94 (30%)
Ig 264..334 CDD:143165 23/73 (32%)
I-set 345..433 CDD:254352 24/98 (24%)
Ig 358..431 CDD:143165 18/76 (24%)
Ig 456..533 CDD:143165 21/81 (26%)
IGc2 553..619 CDD:197706 12/65 (18%)
I-set 634..724 CDD:254352 14/89 (16%)
ig 645..712 CDD:278476 8/66 (12%)
IG_like 734..815 CDD:214653 22/91 (24%)
Ig 745..815 CDD:299845 21/80 (26%)
I-set 820..913 CDD:254352 11/94 (12%)
Ig 838..920 CDD:299845 9/81 (11%)
FN3 917..1033 CDD:238020 19/118 (16%)
FN3 1040..1142 CDD:238020 22/114 (19%)
fn3 1150..1237 CDD:278470 22/92 (24%)
FN3 1263..1345 CDD:238020 12/107 (11%)
Ig 1350..1436 CDD:299845 16/85 (19%)
IG_like 1358..1436 CDD:214653 14/77 (18%)
FN3 1441..1530 CDD:238020 14/97 (14%)
FN3 1542..1620 CDD:238020 8/82 (10%)
robo3NP_608592.2 Ig 22..117 CDD:299845 30/101 (30%)
I-set 23..116 CDD:254352 30/100 (30%)
I-set 122..211 CDD:254352 24/95 (25%)
Ig 125..211 CDD:299845 24/92 (26%)
I-set 215..302 CDD:254352 27/101 (27%)
Ig 232..302 CDD:299845 22/84 (26%)
I-set 306..401 CDD:254352 27/182 (15%)
Ig 320..411 CDD:299845 28/178 (16%)
I-set 412..492 CDD:254352 21/86 (24%)
IGc2 429..489 CDD:197706 17/63 (27%)
FN3 519..612 CDD:238020 24/174 (14%)
FN3 644..735 CDD:238020 21/111 (19%)
fn3 743..832 CDD:278470 22/92 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45452275
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.