DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Sdk1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_808547.3	Gene:	Sdk1 / 330222	MGIID:	2444413	Length:	2193	Species:	Mus musculus

Alignment Length:	1971	Identity:	457/1971 - (23%)
Similarity:	691/1971 - (35%)	Gaps:	563/1971 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 LPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRR 410
            |||:.:  .|......|...||......|:.|      ::.|||      :.|:...::.::.:.
Mouse    94 LPQIHL--EGNRLVLTCLAEGSWPLEFKWIRN------DSELTT------YSSEYKYIIPSLQKL 144

  Fly   411 DRGVYQCLVENQR-ASAQAMAELKLGDTVPELIYTFIEQNVRPG--------PLISLKCSASGSP 466
            |.|.|:|:|.|:. |..|..:|:::. .:...:.|...:.|..|        |::|  |     |
Mouse   145 DAGFYRCVVRNRMGALLQRKSEIQVA-YMGNFMDTDQRKTVSQGHAALLNLLPIVS--C-----P 201

  Fly   467 PPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHS 531
            .||..|..:...|:..|   |.||        .:.:.|.|......|.|.|...|.|.......:
Mouse   202 QPQVTWFREGHKIIPSS---RIAI--------TLENQLVILATTASDAGAYYVQAVNEKNGENKT 255

  Fly   532 A---RLNV---------YGPPYVRAIGPIKAVAG-EDIIVHCPFAGYPVEQ--IRWEKAHQELTT 581
            :   .|:|         ..|..|.|.|....||| .:..:.|.....|||:  :.|::....||:
Mouse   256 SPFIHLSVARDTGTHEAMAPIIVVAPGNRSVVAGSSETTLECIANARPVEELSVHWKRNGVRLTS 320

  Fly   582 SNHYELASVADGGQLVIKNVEPGRDQGIYTC--IVRSRAGEEARRDMQLNVNSPP--VIEP-FKF 641
            ..|      :.|.:|.|.| ....|.|:|.|  .:|....|.||....|::..||  ..|| .:.
Mouse   321 GLH------SYGRRLTITN-PTSADTGMYVCEATLRGSTFEPARARAFLSIIEPPYFTAEPESRI 378

  Fly   642 PKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIP-SSLQITEKKEEFYSLLVFKDISARHSGKY 705
            ...::|  ...|.|......:|. ..|.||  ::| |.||....|......|..:.:|...||.:
Mouse   379 LGEVEE--TMDIPCRAMGVPLPT-LQWYKD--AVPLSKLQNPRYKVLPSGGLHIQKLSPEDSGIF 438

  Fly   706 TCYASNAAAKVNYTAELQV-RVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQ---G 766
            .|:|||...:|.....|.| .:||.:...|:||.:..|.|..:.||..|.|.|.|||.:|.   .
Mouse   439 QCFASNEGGEVQTHTYLDVTNIAPAFTQRPVDTTVTDGMTAVLRCEVSGAPKPAITWKRGNHILA 503

  Fly   767 KGSKDFKPLSMRNHSLLLNLAT--DNDEGYYMCQATN---EIGAGLKKTI--RINVNEPARFEQS 824
            .||... |..|...|..|.:|.  ..|.|.|.|.|.|   .:.|....|:  |.::..|......
Mouse   504 SGSVRI-PRFMLLESGGLRIAPVFIQDAGNYTCYAANTEASVNASAMLTVWNRTSIVHPPEDRVV 567

  Fly   825 ARNISSRRNDPVTLDCHAKGDEPITIG--WTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSD 887
            .:..::      ||.|.|..|...::.  |.::|..|..:    |.:.:..||  |..|.|..:.
Mouse   568 IKGTTA------TLCCGATHDPRTSLRYVWKKDNVVITAS----SSSRIVVEK--DGSLVISQTW 620

  Fly   888 RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHL--EIFEVGSRTVKLSWRRPFDGNSPVLSY 950
            ..|.|.|.|...:..|...:...|.|.|.|..|.:|  .:....|.:|.|||.||||||||||.|
Mouse   621 SGDIGDYTCEIISEGGSDSRTARLEVIELPHPPQNLLASLSPARSHSVTLSWVRPFDGNSPVLYY 685

  Fly   951 LVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQ 1015
            :||            ::.....|..|:.||....|.::            |:|||||.|:..|:.
Mouse   686 IVQ------------VSENNSPWKVHLSNVGPEMTGVT------------VSGLTPARTYQFRVC 726

  Fly  1016 AINEIERSAY-TEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTV--- 1076
            |:|::.:..| ||...|...||.|:..|.|:.........::|.||.||....||.|.||.:
Mouse   727 AVNQVGKGQYSTETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYR 791

  Fly  1077 --NCSEEKQNINFIS-VVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAI 1138
              ....|.|..|..| .||..|.:.::.              :::|.:.:.|.|..|.|.:|.|:
Mouse   792 LAGLPGEHQQRNISSPEVNYCLVTDLII--------------WTQYEIQVAAYNGAGLGVFSRAV 842

  Fly  1139 FGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIK 1203
            ...|.:|||.|.||||...|::|.::...|..||.||..||.||||:|..|    .|.|
Mouse   843 TEYTLQGVPTAPPQNVQAEAVNSTTVHFLWNPPPQQFINGINQGYKLLAWP----ADAP------ 897

  Fly  1204 RTSNLET-----------YLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKA 1257
            .|..:.|           |:..|.|.:.|...||.:|..|||..|.|....|.:|.|.|...:..
Mouse   898 ETVTVVTIAPDFHGIHHGYITNLKKFTAYFTSVLCFTTPGDGPPSSPQLVWTHEDKPGAVGHLSF 962

  Fly  1258 AALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMY 1322
            ..:...|:.:||..|..|||||..|.:.....||.....||.:....:.|.:    :.|:....|
Mouse   963 TEILDTSLKVSWQEPLERNGIIMGYQISWEVYGRNDSRLTHTLNSTMHEYKI----QGLSSLTTY 1023

  Fly  1323 EFWVSASTSVG------------------------------------------------------ 1333
            ...|:|.|:.|
Mouse  1024 TIDVAALTAAGVGVTTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTAICRWIVE 1088

  Fly  1334 ------------------EGEPTSVIAQATN-------------------------------TRA 1349
                              |.||.:.:.:..|                               .:|
Mouse  1089 GQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMRQVNIVGPSPFSQSSRVIQTLQA 1153

  Fly  1350 PARIASFGQVVRKAVGTGLVLECLAV------GNPTP---RARWLTRDRP--------------- 1390
            |..:|.....||.|..|.|.|..:.:      |||..   |.::...|:|
Mouse  1154 PPDVAPTSLTVRTASETSLRLRWVPLPDSQYNGNPESVGYRVKYWRSDQPSSALAQVVSDRLERE 1218

  Fly  1391 ---------------------VTFSPFYEV----TNEG-------NLKIHRVEGS---------- 1413
                                 :...|:.|:    |.|.       |:....|..:
Mouse  1219 LTIEELEEWTEYELRMQAFNAIGAGPWSELVRGRTRESVPSAAPENVSAEAVSSTQILLTWASVP 1283

  Fly  1414 ----------------------------LSGNYTCTANNLFGSDEI---QYQVIAMK-----PPS 1442
                                        :.||:|.:| .|.|..:.   :.||:|..     .||
Mouse  1284 EQDQNGLILGYKVLYCAKDLDPEPRSHVVRGNHTQSA-LLAGLRKFVVYELQVLAFTRIGNGVPS 1347

  Fly  1443 APQIIVQYASAD----------------SIRVSWDAPDDGGAPLQGYTISYHTAGES-------- 1483
            :| :|::....|                ::|:.|..|::....:.||.|:|..|..|
Mouse  1348 SP-LILERTKDDTPGPPVRLVFPEVRLTAVRIVWQPPEEPNGVILGYQIAYRLASGSPHTFTTVE 1411

  Fly  1484 -------WSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNAN 1541
                   ::.|||.||            :.||.::||....|.|...|...:.|:.:...|| ..
Mouse  1412 VGATVRQFTATELAPE------------SAYIFRLSAKTRQGWGEPLEATVITTEKRERPAP-PR 1463

  Fly  1542 ELIATNA--TCVNLKLSSW---QNGGCSIHHFSIEHRPLGDIRWTVVTSDISN------AEENRE 1595
            ||:...|  |..:|:| .|   .:|...|.:|:::.|.|....|...:|.||:      .|..|
Mouse  1464 ELLVPQAEVTARSLRL-QWVPGSDGASPIRYFTVQVRELPGGEWQTYSSSISHEATACAVERLR- 1526

  Fly  1596 NLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPT 1660
                    |...|:||:.||||.|                    .|.|.:|.:.:..|.:.....
Mouse  1527 --------PFTSYKLRLKATNDIG--------------------DSDFSAETEAVTTLQDVPGEP 1563

  Fly  1661 SGDWFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGY-------ESRT----LPGDYKEDHEN 1714
            .|...||     ..|.|.:.|........:|.| :.:||       ||.|    .|...|.....
Mouse  1564 PGSVSAT-----PHTTSSVLIQWQPPRDESLNG-LLQGYRIYYRELESETGMSPEPKTLKSPSAL 1622

  Fly  1715 RRNQQVYSASPVKTVDKGNESEMYEISP----------YATFSVNGGRTGAPAKTPTR------- 1762
            |  .::.:.|..|||:..:....||::.          ...:::.|   .:||..|..
Mouse  1623 R--AELTAQSSFKTVNSSSSLTTYELTHLKKYRRYEVIMTAYNIIG---ESPASVPVEVFVGEAA 1682

  Fly  1763 -AVAAQ----TPLDYTMQFKTFG--HPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDE 1820
             |:|.|    |||..:....|:.  .||.:|.|...|.:.    :....|::...|.:.....:.
Mouse  1683 PAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKVY----YWEADSRNETEKMKVLFLPEP 1743

  Fly  1821 STLSKSMT--------IVAGSQAGHSKKSN--GGRSAKSSAACSGVVAGSE-SDTSIS-----PS 1869
            ....|.:|        |.|.:.||...||:  .||:.:::......:|.|| :.|:::     ||
Mouse  1744 VVKIKDLTSHTKYLISISAFNAAGDGPKSDPCQGRTHQAAPGPPSFLAFSEITSTTLNVSWGEPS 1808

  Fly  1870 TEFSNMPTYRVPCKSSRSSDG-----------------------RAVVDMFRPDSST-------E 1904
            .....:..|||..:......|                       :.|...||..:.|       :
Mouse  1809 AANGILQGYRVVYEPLAPVQGVSKVVTVDVKGNWQRWLKVRDLTKGVTYFFRVQARTIAYGPELQ 1873

  Fly  1905 SNNDQGSPAPERRHNTPRHVL 1925
            :|...| || |....:||:||
Mouse  1874 ANVTAG-PA-EGSPGSPRNVL 1892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	22/87 (25%)
		Ig	358..431	CDD:143165	17/73 (23%)
		Ig	456..533	CDD:143165	18/79 (23%)
		IGc2	553..619	CDD:197706	18/70 (26%)
		I-set	634..724	CDD:254352	25/93 (27%)
		ig	645..712	CDD:278476	19/67 (28%)
		IG_like	734..815	CDD:214653	30/90 (33%)
		Ig	745..815	CDD:299845	25/79 (32%)
		I-set	820..913	CDD:254352	20/94 (21%)
		Ig	838..920	CDD:299845	22/83 (27%)
		FN3	917..1033	CDD:238020	40/118 (34%)
		FN3	1040..1142	CDD:238020	26/107 (24%)
		fn3	1150..1237	CDD:278470	33/97 (34%)
		FN3	1263..1345	CDD:238020	24/153 (16%)
		Ig	1350..1436	CDD:299845	27/182 (15%)
		IG_like	1358..1436	CDD:214653	25/174 (14%)
		FN3	1441..1530	CDD:238020	26/119 (22%)
		FN3	1542..1620	CDD:238020	26/88 (30%)
Sdk1	NP_808547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		Ig_2	94..169	CDD:290606	22/88 (25%)
		IG_like	100..169	CDD:214653	19/80 (24%)
		IG_like	183..263	CDD:214653	22/97 (23%)
		Ig	197..247	CDD:299845	17/67 (25%)
		IG_like	281..357	CDD:214653	22/82 (27%)
		IGc2	294..347	CDD:197706	16/59 (27%)
		I-set	368..457	CDD:254352	25/93 (27%)
		Ig	388..454	CDD:143165	20/68 (29%)
		I-set	462..552	CDD:254352	29/90 (32%)
		Ig	476..552	CDD:299845	25/76 (33%)
		I-set	557..646	CDD:254352	21/100 (21%)
		Ig	562..646	CDD:299845	20/95 (21%)
		FN3	650..741	CDD:238020	39/114 (34%)
		fn3	753..839	CDD:278470	24/99 (24%)
		FN3	854..949	CDD:238020	35/104 (34%)
		FN3	954..1036	CDD:238020	23/85 (27%)
		FN3	1052..1148	CDD:238020	4/95 (4%)
		FN3	1158..1253	CDD:238020	15/94 (16%)
		FN3	1261..1349	CDD:238020	13/88 (15%)
		FN3	1360..1453	CDD:238020	21/104 (20%)
		FN3	1459..1554	CDD:238020	32/125 (26%)
		FN3	1562..1676	CDD:238020	26/124 (21%)
		FN3	1686..1779	CDD:238020	22/96 (23%)
		FN3	1784..1865	CDD:238020	13/80 (16%)
		FN3	1885..1978	CDD:238020	4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2057..2080
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2187..2193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810