DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP006721

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_001688154.1	Gene:	AgaP_AGAP006721 / 3290216	VectorBaseID:	AGAP006721	Length:	648	Species:	Anopheles gambiae

Alignment Length:	666	Identity:	113/666 - (16%)
Similarity:	200/666 - (30%)	Gaps:	220/666 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1441 PSAPQ-IIVQYASADSIRVSWD-APDDGGAPLQGYTISYHTAGESWSITELLPEN-NAFTISGLK 1502
            |:||: |.|.:.:..|:||||. :.|....|:..|.::|.....|:.:..::..| :|.|:.||.
Mosquito     3 PTAPENITVTFLTPTSVRVSWQTSMDPHTMPVDKYDVTYKPTDASYRVVVVVAGNRDAVTLGGLT 67

  Fly  1503 CGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIHH 1567
            ...||.:.::|              ||...|....|
Mosquito    68 PDTQYQLTVAA--------------VWNGKKYRSRP----------------------------- 89

  Fly  1568 FSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAK--WYQLRISATNDAGKTTEHYHFSTT 1630
                                         ::|....|.:  :.|...|....:|.....:..:..
Mosquito    90 -----------------------------IVFRTLEPPRTSYQQDSGSLVGSSGPPNSPHADTAP 125

  Fly  1631 NIDGITIPPPSVFPSENDLMNNLINSTN---PT-SGDWFATLIVVVIITVSIITIALTIKHRRTL 1691
            ::.||     .:|..|  ..|..:|||:   || .|.....:::|:|:....|.:......:..:
Mosquito   126 SLSGI-----GIFTEE--FGNISVNSTSRELPTIRGVEIGIVVLVLIVWAGAIALFFNRWGKIRM 183

  Fly  1692 CGPIAEGYESR-------------TLPGDYKEDHENR-RNQQVYSASPVKTVDKGNESE-----M 1737
            ..|....|:..             |..|.:...|... ......:|.|..|.:....||     .
Mosquito   184 LLPYQPDYKQEQLKVPGTGVCANGTCNGQHSHQHPGADAAAPAPAAHPALTTEDAAASEPLAAQP 248

  Fly  1738 YEISPYATFSVNGGRTGAPA-KTPTRAVAAQTPLDY-----TMQFKTFG------------HPEG 1784
            :...|:...:....|.|.|| ::|...:...:.:.:     .:.....|            ||.|
Mosquito   249 HHSHPHLAVAAAAPRHGEPALRSPAHEIRRHSMVPHGTVPTLLHHAHHGSRQPLLGAGHHPHPPG 313

  Fly  1785 ENL--NATAYPLL----------------PS-------------------------SGFGHVKSK 1806
            .:|  :...:|||                ||                         ...|...|.
Mosquito   314 HSLANHRHVHPLLQRHRSEDRPLLRHAHRPSMVGCQRHLTKPLLQRPLLTHAHSVQQAAGAAAST 378

  Fly  1807 SSWHKQRYYNTEDESTLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGS-----ESDTSI 1866
            ...|...::::....:.....|:.:.|:...|..|.|..|....|..||..:.|     :.|...
Mosquito   379 PHHHAPHHHHSHPRLSQKYRQTLFSRSKQYTSVCSGGSNSTTHCAGDSGTRSRSSREHADDDVEA 443

  Fly  1867 SPSTEFSNMPTYRVPCKSSRSSDGRAVVDMFRPDSSTESNNDQGSPAPE--RRHNTPRHVLGMGM 1929
            .|...:...|:..:..:.:|:....|:.         .|:..:|..:.|  ||:.:...:.....
Mosquito   444 CPYHPWPEEPSSVISERCTRARINSAIF---------VSSEGKGFDSIEFIRRYGSQSVLCRKAK 499

  Fly  1930 AMGLGGGGGGGVGGGNGPAEKRSAGQRSRK---------------HGSAAQQPSNQTLERRKCPG 1979
            :                 ||..||.:|.|:               :|::|...||   .|||...
Mosquito   500 S-----------------AENVSASERQRRFSEYPEWETEDSTTGNGTSAHSASN---ARRKKSL 544

  Fly  1980 SSNSLDS-EVDAETAA 1994
            ..:|::. |...|.||
Mosquito   545 RQDSIEMVECHKEPAA 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020	24/91 (26%)
		FN3	1542..1620	CDD:238020	4/79 (5%)
AgaP_AGAP006721	XP_001688154.1	FN3	3..94	CDD:238020	28/162 (17%)
		DUF4808	151..>217	CDD:292684	9/65 (14%)
		PKc_like	242..>339	CDD:304357	15/96 (16%)
		DUF4808	<407..498	CDD:292684	18/99 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910