DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP006350

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_557013.3	Gene:	AgaP_AGAP006350 / 3290147	VectorBaseID:	AGAP006350	Length:	319	Species:	Anopheles gambiae

Alignment Length:	310	Identity:	70/310 - (22%)
Similarity:	110/310 - (35%)	Gaps:	77/310 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 DAGKW-------ICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDA 371
            :.|.|       ...|.:|:.|.:.::.:|.|           ..|..|.||...|.....|..:
Mosquito    17 ETGPWSTSTRRYYATADHQWAEPQFDLSVSRN-----------VTVREGETAFLTCRVENLAKYS 70

  Fly   372 IDWL-HNGKPLQANNALTTGRDNIRF-------LSKSSLLVQNVGRRDRGVYQCLVENQRASAQA 428
            |.|: |:...:.|.||.|...|. ||       .::.:|.::...|:|..:|:|.:     |...
Mosquito    71 ISWVRHHDLHILAINADTFTSDE-RFQALYNDQTAEWTLKLRRTRRKDTDIYECQI-----STMP 129

  Fly   429 MAELKLGDTVPE--------------LIYTFIEQNVRPGPLISLKCSASGS---PPPQFAWLLDS 476
            :..|:|...|.:              ::|.:..|||      :|.|..:.:   .|....|....
Mosquito   130 VKSLQLYLIVLDYHFLTTTTQILEGTIVYGYKGQNV------NLTCIVNHNYDRRPSHIVWYHQK 188

  Fly   477 QPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVAS--NSMGSVQH------SAR 533
            ..:...||..|   |:  .....:.|:..|.....||.|.|.|...  .|..::.|      ...
Mosquito   189 DIVAYESLRKR---GR--SSLNSITSYHLIRSAEFDDAGNYTCAPELYPSASTIVHILDGRWDGG 248

  Fly   534 LNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSN 583
            .:|.....|.||....|||.....:...|||        |:| |||::||
Mosquito   249 RDVRWRQCVGAIFNALAVARSLPALLVAFAG--------EEA-QELSSSN 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	5/29 (17%)
		Ig	264..334	CDD:143165	5/26 (19%)
		I-set	345..433	CDD:254352	22/95 (23%)
		Ig	358..431	CDD:143165	19/80 (24%)
		Ig	456..533	CDD:143165	17/87 (20%)
		IGc2	553..619	CDD:197706	10/31 (32%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP006350	XP_557013.3	Ig	45..139	CDD:299845	26/110 (24%)
		IG_like	46..126	CDD:214653	23/96 (24%)
		IG_like	157..227	CDD:214653	18/80 (23%)
		Ig	165..>226	CDD:143165	15/71 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810