DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and dpr18

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	84/438 - (19%)
Similarity:	131/438 - (29%)	Gaps:	185/438 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 IYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMP--IYFSWKKD 671
            |.|.:.|.:...|....|:.:.||.|:       ||:  |...|:|...    ||  .:.|.|.|
  Fly   125 IPTKMSRGKIPMETPGSMEFSSNSLPI-------KNV--GTTDQLTTVT----MPTTAFASLKVD 176

  Fly   672 DSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVA--PRWRY-- 732
            .|::...:..|..:.                              ::||....||.  ||.::
  Fly   177 RSTMKQPIDSTRTRN------------------------------HWTASGFARVTERPRSKHHH 211

  Fly   733 ---------EPMDTAIMLGNTIS---------INCEAEGYPIPTITW-----------------F 762
                     ||:::|....|.:|         :||........|:.|                 :
  Fly   212 EHHWGPFFEEPINSATSGDNLVSAVHLFTEAVLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTY 276

  Fly   763 KGQGKGSKDFK-PLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPAR--FEQS 824
            .|..:....|: |   .|..||:|.....|.|.||||.:.......  |..:.|.||..  .::.
  Fly   277 SGDPRIRVKFQYP---NNWRLLINPTQTEDAGVYMCQVSTHPPRVF--TTNLTVLEPPLRIIDEH 336

  Fly   825 ARNISSR---RNDPVTLDCH--------------------------------------------- 841
            .|::..|   ....|.|.|.
  Fly   337 ERDVGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTDSANDAVQKLINETTSELNLIGNVNQTQ 401

  Fly   842 ------------------AKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDR 888
                              ||.:||:.          .:.|.|.|::::    .:.|:::||.:..
  Fly   402 HKFSGQDLEKYFTKFITWAKDEEPLQ----------GMTNRRLSVSDV----WLTSRISIGDAKL 452

  Fly   889 HDSGVYRCIAENPYGRAEQIIFLAVQ----ERPDTPSHLEIFEVGSRT 932
            .|||.|.|    ..||...:| :.||    |.|....|    .:||||
  Fly   453 SDSGNYSC----SLGRLFTVI-VQVQVLTGELPAAVQH----NIGSRT 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706	3/9 (33%)
		I-set	634..724	CDD:254352	15/91 (16%)
		ig	645..712	CDD:278476	10/68 (15%)
		IG_like	734..815	CDD:214653	22/107 (21%)
		Ig	745..815	CDD:299845	19/96 (20%)
		I-set	820..913	CDD:254352	23/160 (14%)
		Ig	838..920	CDD:299845	24/148 (16%)
		FN3	917..1033	CDD:238020	6/16 (38%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	18/87 (21%)
		Ig	<258..326	CDD:299845	15/72 (21%)
		IGc2	<417..461	CDD:197706	15/61 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810