DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Lrig3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_796126.4	Gene:	Lrig3 / 320398	MGIID:	2443955	Length:	1117	Species:	Mus musculus

Alignment Length:	1013	Identity:	199/1013 - (19%)
Similarity:	329/1013 - (32%)	Gaps:	341/1013 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LGALLLAVLATPLLATSGLRVPTFLLEPAPRLLFGNDTGAQVTCTA--H--GS------------ 65
            ||.||.|.|.....|.||       ...||..|..:|  ||..|.|  |  |.
Mouse    13 LGLLLCAGLGRAGPAGSG-------GHGAPGQLLDDD--AQRPCPAACHCLGDLLDCSRRRLVRL 68

  Fly    66 PPPLVTWVLR-----------DGSLATQVPGLRKIS-GNGTLHFPPFLAQYYRTDVHEATYRCRA 118
            |.||..||.|           ..|..:.:..|:::. .|..|...|.|.. ...::.:.:.   |
Mouse    69 PDPLPAWVTRLDLSHNRLSFIQTSSLSHLQSLQEVKLNNNELETIPNLGS-ISANIRQLSL---A 129

  Fly   119 SNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYV-----RVASWHRGE 178
            .|....:|...::...        .:|..::...|.:.::.|.|.....|:     ||:|...|.
Mouse   130 GNAIDKILPEQLEAFQ--------SLETLDLSNNNISELRTAFPPLQLKYLYINNNRVSSMEPGY 186

  Fly   179 EILLPDLSDVAGRYVVLAASG-------------------DLYVRSVRSEDGLMKFSCLVTNTLN 224
                  ..::|...:||..:.                   :|....:::.|||.........:|.
Mouse   187 ------FDNLASTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLK 245

  Fly   225 GERQRSDAVM---------LQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTW 280
            .:|.....:|         ::|.:|..|.....|:                            .|
Mouse   246 MQRNGVTKLMDGAFWGLSNMEVLQLDHNNLTEITK----------------------------GW 282

  Fly   281 YRVSDSAALYPIPSSQRVILSRTLLLIKNADER---DAGKWICQASNQFGEQRIEIRLSVN---- 338
                    ||.:      ::.|.|.|.:||..|   ||  |      :|.::..|:.|:.|
Mouse   283 --------LYGL------LMLRELHLSQNAINRISPDA--W------EFCQKLSELDLTFNHLSR 325

  Fly   339 ----SYVSVHILPQVQIVNSGGTANFNCTTTG-SAIDAIDWLHNGK---PLQANNALTTGRDNIR 395
                |::.:.:|..:.|.|:..:...:|...| :::..:| |.|.:   .::..:...:|.|.:|
Mouse   326 LDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLKTLD-LRNNEISWTIEDMSGAFSGLDRLR 389

  Fly   396 FLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKC 460
                 .|::|  |.|.|.:          :.:|.|.|   ||:..|
Mouse   390 -----QLILQ--GNRIRSI----------TKKAFAGL---DTLEHL------------------- 415

  Fly   461 SASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSM 525
                                              |:||:.|..|.                ||:.
Mouse   416 ----------------------------------DLSGNAIMSLQ----------------SNAF 430

  Fly   526 GSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASV 590
            ..::...:|:               :....::..|        |:||  ..|.:..:|.....:.
Mouse   431 SQMKKLQQLH---------------LNTSSLLCDC--------QLRW--LPQWVAENNFQSFVNA 470

  Fly   591 ADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPK----------NL 645
            :.....::|    ||  .|:|.                   ||.......|||          :.
Mouse   471 SCAHPQLLK----GR--SIFTV-------------------SPDGFVCDDFPKPQITVQPETQSA 510

  Fly   646 QEGGRAQITC-AVSSGDMPIYFSWKKDDSSIPSSLQITEKKE------------EFYSLLVFKDI 697
            .:|.....|| |.||.|.|:.|:||||:    .:||..|.:.            |:.::|..:::
Mouse   511 IKGSDVSFTCSAASSSDSPMTFAWKKDN----EALQDAEMENYAHLRAQGGELMEYTTILRLRNV 571

  Fly   698 SARHSGKYTCYASN-AAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITW 761
            .....|||.|..|| ..:..:..|:|.:.:.|.:...|||..|..|....:.|.|.|:|.|.|.|
Mouse   572 EFTSEGKYQCVISNHFGSSYSVKAKLTINMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAW 636

  Fly   762 FKGQGKGSKDFKPLSMRNHSLL----LNLATD---NDEGYYMCQATNEIGAGLKKTIRINVNEPA 819
               |..|..||.....|...::    :....|   .|.|.|.|.|.|..|: :.....:.|.|..
Mouse   637 ---QKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGS-VSANATLTVLETP 697

  Fly   820 RFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIG 884
            .|.:...:.:..:.:...|.|.|.|..|..:.||:::..:.:....|..|.       :..|.|.
Mouse   698 SFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAG-------NQLLIIV 755

  Fly   885 HSDRHDSGVYRCIAENPYGRAEQIIFLAVQERP--DTP 920
            .||..|:|.|.|...|..|.....:.|:|...|  |:|
Mouse   756 DSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSP 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	21/104 (20%)
		Ig	56..125	CDD:143165	20/96 (21%)
		I-set	246..337	CDD:254352	16/93 (17%)
		Ig	264..334	CDD:143165	14/72 (19%)
		I-set	345..433	CDD:254352	18/91 (20%)
		Ig	358..431	CDD:143165	14/76 (18%)
		Ig	456..533	CDD:143165	7/76 (9%)
		IGc2	553..619	CDD:197706	11/65 (17%)
		I-set	634..724	CDD:254352	29/113 (26%)
		ig	645..712	CDD:278476	24/80 (30%)
		IG_like	734..815	CDD:214653	25/87 (29%)
		Ig	745..815	CDD:299845	20/76 (26%)
		I-set	820..913	CDD:254352	21/92 (23%)
		Ig	838..920	CDD:299845	23/83 (28%)
		FN3	917..1033	CDD:238020	3/6 (50%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lrig3	NP_796126.4	LRR 1	75..98		4/22 (18%)
		LRR_8	76..133	CDD:290566	10/60 (17%)
		leucine-rich repeat	76..99	CDD:275378	3/22 (14%)
		LRR_RI	81..324	CDD:238064	48/310 (15%)
		LRR 2	99..120		5/21 (24%)
		leucine-rich repeat	100..146	CDD:275378	8/57 (14%)
		LRR_8	122..179	CDD:290566	8/67 (12%)
		LRR 3	122..143		3/23 (13%)
		LRR 4	146..168		4/21 (19%)
		leucine-rich repeat	147..168	CDD:275380	4/20 (20%)
		LRR_8	168..227	CDD:290566	9/64 (14%)
		leucine-rich repeat	169..192	CDD:275380	5/28 (18%)
		LRR 5	169..189		5/25 (20%)
		LRR 6	193..214		2/20 (10%)
		leucine-rich repeat	194..216	CDD:275380	2/21 (10%)
		LRR_8	215..275	CDD:290566	10/59 (17%)
		LRR 7	216..237		4/20 (20%)
		leucine-rich repeat	217..240	CDD:275380	4/22 (18%)
		LRR 8	240..261		3/20 (15%)
		leucine-rich repeat	241..264	CDD:275380	3/22 (14%)
		LRR_RI	262..>446	CDD:238064	51/338 (15%)
		LRR_8	263..323	CDD:290566	20/109 (18%)
		LRR 9	264..285		6/56 (11%)
		leucine-rich repeat	265..288	CDD:275380	7/64 (11%)
		LRR 10	288..309		9/28 (32%)
		leucine-rich repeat	289..312	CDD:275380	10/30 (33%)
		LRR_8	312..371	CDD:290566	12/59 (20%)
		LRR 11	312..333		4/20 (20%)
		leucine-rich repeat	313..336	CDD:275380	4/22 (18%)
		LRR 12	336..357		4/20 (20%)
		leucine-rich repeat	337..360	CDD:275380	5/22 (23%)
		LRR_8	359..422	CDD:290566	20/136 (15%)
		LRR 13	360..382		3/22 (14%)
		leucine-rich repeat	361..385	CDD:275380	3/24 (13%)
		LRR 14	387..408		7/37 (19%)
		leucine-rich repeat	388..411	CDD:275380	9/42 (21%)
		LRR 15	411..432		9/89 (10%)
		leucine-rich repeat	412..433	CDD:275380	8/89 (9%)
		LRRCT	446..494	CDD:214507	13/82 (16%)
		I-set	499..599	CDD:254352	26/103 (25%)
		Ig	500..587	CDD:299845	24/90 (27%)
		I-set	603..693	CDD:254352	26/93 (28%)
		Ig_1	620..694	CDD:143240	20/77 (26%)
		I-set	697..784	CDD:254352	21/93 (23%)
		IGc2	711..774	CDD:197706	18/69 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910