DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Fas2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	208/956 - (21%)
Similarity:	317/956 - (33%)	Gaps:	305/956 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 QKPVMEIH----VER---GNDVHLPCNIQGNPFPIFT----WYRVSDSAALYPIPS--SQRVILS 301
            |.|::||:    |:|   |..:.|.|. ...|.|...    | :.:.:..:.|.|:  :|..:.:
  Fly    29 QSPILEIYPKQEVQRKPVGKPLILTCR-PTVPEPSLVADLQW-KDNRNNTILPKPNGRNQPPMYT 91

  Fly   302 RTL------LLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSV--HILPQVQIVNSGGTA 358
            .||      |:|.:......||:.|.|| ....:.:|..:::.:||::  ...|:.|....|...
  Fly    92 ETLPGESLALMITSLSVEMGGKYYCTAS-YANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDY 155

  Fly   359 NFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQR 423
            ...|.........||||.||.|::..|.....:.|       .||::||...|.|:|.|     |
  Fly   156 VVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTN-------GLLIRNVQESDEGIYTC-----R 208

  Fly   424 ASAQAMAELKLGDTV-------PELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMD 481
            |:.....|| |..|:       ||:|..........|...:..|:|.|.|.|:.:|:.|:.. ::
  Fly   209 AAVIETGEL-LERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQ-LN 271

  Fly   482 VSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIG 546
            |:...||.:.....:       :.||.|..||.|.|.|:|.|..|.|....:|||...|.:..:.
  Fly   272 VATADRFQVNPQTGL-------VTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELY 329

  Fly   547 PIKAVAGEDIIVHCPFAGYPVEQI---RWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQG 608
            .:.....::|.:.|...|.|...|   ||       .|...|......|..::::   ||..|
  Fly   330 NVTGARTKEIAITCRAKGRPAPAITFRRW-------GTQEEYTNGQQDDDPRIIL---EPNFD-- 382

  Fly   609 IYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDS 673
                                                 :|.|.:..|..:|:.:       :.||
  Fly   383 -------------------------------------EERGESTGTLRISNAE-------RSDD- 402

  Fly   674 SIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTA 738
                                         |.|.|.|.|..|....|..:.|..||.:.:
  Fly   403 -----------------------------GLYQCIARNKGADAYKTGHITVEFAPDFSH------ 432

  Fly   739 IMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEI 803
                        .:..| |..:|
  Fly   433 ------------MKELP-PVFSW------------------------------------------ 442

  Fly   804 GAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRI-DLNNFRFS 867
                              ||...|:|          |.|.|....||.|..|..:| ||.:....
  Fly   443 ------------------EQRKANLS----------CLAMGIPNATIEWHWNGRKIKDLYDTNLK 479

  Fly   868 IAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRT 932
            |    ...|..|.|.:....|.....|:|||.|.:|.||..:.|.....||..|..:..::.:.|
  Fly   480 I----VGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATT 540

  Fly   933 VKLSWRRP-FDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLR 996
            :....|.| .:...|:|:|.|||:           .|...||          ||:.:||:..|
  Fly   541 MTFDIRGPSTELGLPILAYSVQYK-----------EALNPDW----------STAYNRSWSPD-- 582

  Fly   997 ESAIVAGLTPATTFLIRMQAINEI--------------ERSAYTEAIVLKTQEEAPTEAPSNVQV 1047
            ...||.||.|.|.:..|..|.|::              .|||        .:|..|...|    |
  Fly   583 SPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSA--------PEEPKPLHNP----V 635

  Fly  1048 QTGGESELIVT---------WQIPPRESWNGELIG-YTVN-CSEEKQNINFISVVNSSLKSTIVS 1101
            |...|..::|:         |.:|   :.|||.|. |.:. |...|.:..:..:.||   ...|.
  Fly   636 QHDKEEPVVVSPYSDHFELRWGVP---ADNGEPIDRYQIKYCPGVKISGTWTELENS---CNTVE 694

  Fly  1102 GWATTKATLRGLRKYSRYAVTIRAMNSFG-SGPWSAAIFGTTAEGV 1146
            ...||...:..|...:.|.:.::|.|:.| |.|  |:|...|..|:
  Fly   695 VMETTSFEMTQLVGNTYYRIELKAHNAIGYSSP--ASIIMKTTRGI 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	25/105 (24%)
		Ig	264..334	CDD:143165	18/81 (22%)
		I-set	345..433	CDD:254352	24/87 (28%)
		Ig	358..431	CDD:143165	20/72 (28%)
		Ig	456..533	CDD:143165	22/76 (29%)
		IGc2	553..619	CDD:197706	13/68 (19%)
		I-set	634..724	CDD:254352	13/89 (15%)
		ig	645..712	CDD:278476	10/66 (15%)
		IG_like	734..815	CDD:214653	3/80 (4%)
		Ig	745..815	CDD:299845	3/69 (4%)
		I-set	820..913	CDD:254352	28/93 (30%)
		Ig	838..920	CDD:299845	26/82 (32%)
		FN3	917..1033	CDD:238020	32/130 (25%)
		FN3	1040..1142	CDD:238020	28/113 (25%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/96 (22%)
		IG_like	144..226	CDD:214653	27/94 (29%)
		IGc2	152..209	CDD:197706	19/68 (28%)
		I-set	230..319	CDD:254352	27/96 (28%)
		IGc2	243..309	CDD:197706	21/73 (29%)
		IG_like	330..424	CDD:214653	26/179 (15%)
		IGc2	339..412	CDD:197706	23/158 (15%)
		Ig	447..518	CDD:143165	25/84 (30%)
		fn3	534..611	CDD:278470	26/99 (26%)
		FN3	640..735	CDD:238020	25/102 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830