DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and rst

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001284835.1	Gene:	rst / 31290	FlyBaseID:	FBgn0003285	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	170/837 - (20%)
Similarity:	282/837 - (33%)	Gaps:	222/837 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 EQNVRPGPLISLKC---SASGSPPPQFAWLLDSQPI---MDVSLHHRFA-IGQFVDMSGDVISHL 504
            :|....|..::|.|   :..|:    ..|..|...:   .|:|...|:| :|.  |..||.  .|
  Fly    36 DQTAVVGARVTLPCRVINKQGT----LQWTKDDFGLGTSRDLSGFERYAMVGS--DEEGDY--SL 92

  Fly   505 NISHVRPDDGGLYKCVAS---NSMGSVQHS-ARLNVYGPPYVRAI---GPIKAVAGEDIIVHC-P 561
            :|..|..||...|:|..|   ....:::.: |.|.|..||....|   ..|.|.....:.:.| .
  Fly    93 DIYPVMLDDDARYQCQVSPGPEGQPAIRSTFAGLTVLVPPEAPKITQGDVIYATEDRKVEIECVS 157

  Fly   562 FAGYPVEQIRWEKAHQELTTSN-HYELASVADGGQLVIKNV---EPGRD--QGIYTCIVRSRAGE 620
            ..|.|..:|.|......:.|.| .|.:..:.|..:...|:|   .|.::  ...::|..::.|..
  Fly   158 VGGKPAAEITWIDGLGNVLTDNIEYTVIPLPDQRRFTAKSVLRLTPKKEHHNTNFSCQAQNTADR 222

  Fly   621 EAR-RDMQLNVNSPPVIE-----------------------PFKFPKNLQEGGRAQITCAVSSGD 661
            ..| ..:::.|...|.::                       .......:.|..:.::.|...:..
  Fly   223 TYRSAKIRVEVKYAPKVKVNVMGSLPGGAGGSVGGAGGGSVHMSTGSRIVEHSQVRLECRADANP 287

  Fly   662 MPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISAR-HSGKYTCYASNAAAKVNYTAELQVR 725
            ..:.:.|..:|..|     |..:|.|    :|.::::.: |.....|...|:..|...:..|.:.
  Fly   288 SDVRYRWFINDEPI-----IGGQKTE----MVIRNVTRKFHDAIVKCEVQNSVGKSEDSETLDIS 343

  Fly   726 VAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGK---GSKDFKPLSMRNHSLLLNLA 787
            .||.:|..|......:|:.:|:.||.:..|.|.|.|.:....   |:......|:.|.:
  Fly   344 YAPSFRQRPQSMEADVGSVVSLTCEVDSNPQPEIVWIQHPSDRVVGTSTNLTFSVSNET------ 402

  Fly   788 TDNDEGYYMCQAT----NEIGA------------GLKKTIRINVNEPARFEQSARNISSRRNDPV 836
                .|.|.|:|.    .||.|            |.::|....|.:.||.|..|.::...|:
  Fly   403 ----AGRYYCKANVPGYAEISADAYVYLKGSPAIGSQRTQYGLVGDTARIECFASSVPRARH--- 460

  Fly   837 TLDCHAKGDEPITIGWTQNNGRIDL-NNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAEN 900
                         :.||.|...|.. :...:||.......||.|.|.|..|..:..|.|.|...|
  Fly   461 -------------VSWTFNGQEISSESGHDYSILVDAVPGGVKSTLIIRDSQAYHYGKYNCTVVN 512

  Fly   901 PYGR--AE-------------------------------QIIFLAVQERPDTP-----SHLEIFE 927
            .||.  ||                               .::::..::|...|     |..:|.:
  Fly   513 DYGNDVAEIQLQAKKSVSLLMTIVGGISVVAFLLVLTILVVVYIKCKKRTKLPPADVISEHQITK 577

  Fly   928 VGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYD 992
            .|..:.||   .|.|..|       .|..||...|.|.:..  ||::.|   .|.|...:
  Fly   578 NGGVSCKL---EPGDRTS-------NYSDLKVDISGGYVPY--GDYSTH---YSPPPQYL----- 622

  Fly   993 SDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIV 1057
                           ||...:....:.|.::.:...:.|:.|::   ::......||   :.|.:
  Fly   623 ---------------TTCSTKSNGSSTIMQNNHQNQLQLQQQQQ---QSHHQHHTQT---TTLPM 666

  Fly  1058 TWQIPPRESWNGELIGYTVNCSEEKQNINF-------ISVVNSSLKSTIVSGWATTKATLRGLRK 1115
            |:.   ..|..|.|.|..:...|.:|:...       .|||:||...: .|..:||.||.
  Fly   667 TFL---TNSSGGSLTGSIIGSREIRQDNGLPSLQSTTASVVSSSPNGS-CSNQSTTAATT----- 722

  Fly  1116 YSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPP 1172
             :...|.:.:..:....|..:||:|              |....||.|   |.|.||
  Fly   723 -TTTHVVVPSSMALSVDPRYSAIYG--------------NPYLRSSNS---SLLPPP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	21/87 (24%)
		IGc2	553..619	CDD:197706	13/72 (18%)
		I-set	634..724	CDD:254352	15/113 (13%)
		ig	645..712	CDD:278476	11/67 (16%)
		IG_like	734..815	CDD:214653	21/99 (21%)
		Ig	745..815	CDD:299845	19/88 (22%)
		I-set	820..913	CDD:254352	24/126 (19%)
		Ig	838..920	CDD:299845	21/115 (18%)
		FN3	917..1033	CDD:238020	23/120 (19%)
		FN3	1040..1142	CDD:238020	25/108 (23%)
		fn3	1150..1237	CDD:278470	8/23 (35%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
rst	NP_001284835.1	IG_like	34..130	CDD:214653	26/101 (26%)
		Ig	42..114	CDD:299845	22/79 (28%)
		C2-set_2	135..225	CDD:285423	17/89 (19%)
		Ig_3	265..329	CDD:290638	11/72 (15%)
		I-set	346..420	CDD:254352	20/83 (24%)
		Ig	360..425	CDD:299845	18/74 (24%)
		Ig5_KIRREL3-like	428..524	CDD:143235	28/111 (25%)
		IG_like	435..524	CDD:214653	27/104 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810