DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Lrfn3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001100972.1	Gene:	Lrfn3 / 308495	RGDID:	1305567	Length:	626	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	136/645 - (21%)
Similarity:	202/645 - (31%)	Gaps:	221/645 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 CNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIE 332
            |..|..|..:     :...|.|..:|.|    |.|....::.||...|.......:|..|  .:.
  Rat    34 CQTQSLPLSV-----LCPGAGLLFVPPS----LDRRAAELRLADNFIAAVRRRDLANMTG--LLH 87

  Fly   333 IRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIR-- 395
            :.||.|:         ::.|.:|..|:         :.|:..||    |..|...:.|...:|
  Rat    88 LSLSRNT---------IRHVAAGAFAD---------LRALRALH----LDGNRLTSLGEGQLRGL 130

  Fly   396 ------FLSKSSLLVQNVGRRDRGVYQC--LVENQRASAQAMAEL------KLGD---------- 436
                  .||.:.|.....|..|    .|  .:|:...|...:.:|      :||:
  Rat   131 VNLRHLILSNNQLAALAAGALD----DCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNL 191

  Fly   437 --TVPELIYTFIEQNVR------------PGPLIS---LKCSASGSPPPQFAWLLDSQPIMDVSL 484
              :||...::.:.:..|            |.||.|   |.....|||...........|:
  Rat   192 LASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPL----- 251

  Fly   485 HHRFAIGQFVDMSGDVISHLNISHV------RPDDGGLYKCVASNSMGSVQHSA---RLNVYGPP 540
                              |.|...|      |.||  |..|.:..::|.....|   ...|..||
  Rat   252 ------------------HCNCELVWLRRLAREDD--LEACASPPALGGRYFWAVGEEEFVCEPP 296

  Fly   541 YVRAIGPIKAV-AGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPG 604
            .|....|..|| ||....:.|...|.|..::||......|..::  ..|.....|.|.:...||
  Rat   297 VVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNS--SRARAFPNGTLELLVTEP- 358

  Fly   605 RDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWK 669
            .|.|.:|||..:.|| ||...::|.|..||       |..|...         :|.|.|
  Rat   359 EDGGTFTCIAANAAG-EATAAVELTVGPPP-------PPQLANS---------TSCDPP------ 400

  Fly   670 KD---DSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWR 731
            :|   |:..|.|                              |::|:|||..|.
  Rat   401 RDGEPDALTPPS------------------------------AASASAKVADTV----------- 424

  Fly   732 YEPMDTAIML---GNTISINCEAEGYPIPTITWFKGQGKGSKD----FKPLSMRNHSLLLNLATD 789
             .|.|..:.:   |.|.::....:..|:|.|..::.|...|.|    ::.:...:.|.||   ||
  Rat   425 -APTDRGVQVTEHGATAALVQWPDQRPVPGIRMYQIQYNSSADDILVYRMIPADSRSFLL---TD 485

  Fly   790 NDEG--YYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEP 847
            ...|  |.:|..                   |.:|.||..:::.|  ||  .|.....||
  Rat   486 LASGRTYDLCVL-------------------AVYEDSATGLTATR--PV--GCARFSTEP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	15/68 (22%)
		Ig	264..334	CDD:143165	14/65 (22%)
		I-set	345..433	CDD:254352	19/103 (18%)
		Ig	358..431	CDD:143165	16/82 (20%)
		Ig	456..533	CDD:143165	16/88 (18%)
		IGc2	553..619	CDD:197706	17/65 (26%)
		I-set	634..724	CDD:254352	16/92 (17%)
		ig	645..712	CDD:278476	9/69 (13%)
		IG_like	734..815	CDD:214653	18/89 (20%)
		Ig	745..815	CDD:299845	14/75 (19%)
		I-set	820..913	CDD:254352	9/28 (32%)
		Ig	838..920	CDD:299845	3/10 (30%)
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lrfn3	NP_001100972.1	LRR	<63..>222	CDD:227223	32/186 (17%)
		leucine-rich repeat	63..84	CDD:275380	4/20 (20%)
		LRR 1	84..105		6/31 (19%)
		leucine-rich repeat	85..108	CDD:275380	6/40 (15%)
		LRR 2	108..129		6/24 (25%)
		leucine-rich repeat	109..132	CDD:275380	6/26 (23%)
		LRR 3	132..153		5/24 (21%)
		leucine-rich repeat	133..157	CDD:275380	6/27 (22%)
		LRR 4	157..178		3/20 (15%)
		leucine-rich repeat	158..181	CDD:275380	4/22 (18%)
		LRR 5	181..202		2/20 (10%)
		leucine-rich repeat	182..205	CDD:275380	2/22 (9%)
		LRR 6	205..226		4/20 (20%)
		leucine-rich repeat	206..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	242..253	CDD:275378	1/33 (3%)
		TPKR_C2	249..>281	CDD:417692	10/56 (18%)
		Ig	296..383	CDD:416386	28/90 (31%)
		Ig strand A	296..299	CDD:409353	1/2 (50%)
		Ig strand A'	303..306	CDD:409353	1/2 (50%)
		Ig strand B	312..320	CDD:409353	1/7 (14%)
		Ig strand C	326..331	CDD:409353	2/4 (50%)
		Ig strand C'	334..336	CDD:409353	0/1 (0%)
		Ig strand D	342..346	CDD:409353	1/3 (33%)
		Ig strand E	349..353	CDD:409353	2/3 (67%)
		Ig strand F	363..370	CDD:409353	3/6 (50%)
		Ig strand G	373..383	CDD:409353	4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..423		17/92 (18%)
		fn3	425..502	CDD:394996	19/98 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000