DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Psg16

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001020850.2	Gene:	Psg16 / 308394	RGDID:	1563849	Length:	480	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	113/540 - (20%)
Similarity:	189/540 - (35%)	Gaps:	162/540 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 TTQKPVME---IHVERGNDV-----HLPCNIQGNPFPIFTWYR----VSDSAALY---------- 290
            ||.:..:|   ..|..|::|     :||.||     .:..|:|    ::.:..||
  Rat    37 TTAQVTIESVPSQVVEGDNVLLLVHNLPENI-----IVLAWFRRLRNMNRAIGLYALNIKVSMMG 96

  Fly   291 PIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGE--QRIEI------------------RL 335
            |:.|.:..:.|...|.|.|..::|.|.:|.|..|:.||  .|..|                  :|
  Rat    97 PVHSGRETVYSNGSLWICNVTQKDTGFYILQTLNRHGEMVSRTSIYLYVYSSLLTGRHTPTFSQL 161

  Fly   336 SVNS-----------YVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALT- 388
            |:.|           ::.||.||:          |.........:...:.|...:.::|.|:..
  Rat   162 SIESVPPNVAEGASVFLQVHNLPE----------NLRVLFWYKGVVVSNNLEIARHIKAKNSSVP 216

  Fly   389 ----TGRDNIRFLSKSSLLVQNVGRRDRGVYQC-LVENQRASAQAMAELKLGDTVPELIYTFIEQ 448
                :||:.:  .|..|||:|||.|.|.|.|.. .:...|....|..:|:: ||
  Rat   217 GPAHSGRETV--YSNGSLLLQNVTRNDTGFYTLRTLSRYRKIELAHVQLQV-DT----------- 267

  Fly   449 NVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDD 513
                        |.|.|     .:|:.|..:|...|....|.|:.|         |...|..|:|
  Rat   268 ------------SLSSS-----CYLVTSAQLMIDPLPRHAAEGESV---------LLQVHNLPED 306

  Fly   514 ---GGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKA 575
               ...||.|:|..:..:          ..|:||...|  :.|            |.:..|
  Rat   307 LQFFSWYKRVSSIQVLKI----------ADYIRATNSI--IKG------------PAQSRR---- 343

  Fly   576 HQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFK 640
                        .:|...|.|:::::.. :|.|:||.....|........:|:.|:. ||.:||.
  Rat   344 ------------ETVYTNGSLLLQHLTE-KDTGLYTLQTIDRNFNIETAPVQVTVHK-PVTQPFM 394

  Fly   641 FPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKY 705
            ...|.....::.:.....|.:..|...|..::.|:..:.:|.....:.:  |....:|...:|:|
  Rat   395 RVTNRTVRVQSSVVFTCFSDNTGICMHWFFNNKSVQLTQRIALSPSKCH--LSIDPVSWEDAGQY 457

  Fly   706 TCYASN-AAAKVNYTAELQV 724
            .|..|| .::|.:....|.|
  Rat   458 QCEVSNPVSSKTSLPVSLAV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	30/130 (23%)
		Ig	264..334	CDD:143165	24/108 (22%)
		I-set	345..433	CDD:254352	21/93 (23%)
		Ig	358..431	CDD:143165	19/78 (24%)
		Ig	456..533	CDD:143165	18/79 (23%)
		IGc2	553..619	CDD:197706	11/65 (17%)
		I-set	634..724	CDD:254352	19/90 (21%)
		ig	645..712	CDD:278476	12/67 (18%)
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Psg16	NP_001020850.2	IG	285..385	CDD:214652	28/149 (19%)
Psg16	NP_001020850.2	IGc2	405..466	CDD:197706	12/62 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000